Conserved Protein Domain Family
NYAP_N

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pfam15439: NYAP_N (This model is not part of the current CDD release)
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 521844
Aligned: 23 rows
Threshold Bit Score: 278.944
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_049331236   44 LYRKSRLDWRHRDQEGKKSSsckdassat----------vgkvrdlasFRRHFRMGFMTMPASQDLSphs------caaA 107 
4_pfamImport    1 LYRKSRLDWRQRDQEGSKKSfsptsfpncssnqndssatvgkvrdlasFRRHFRMGFMTMPASQDLSphs------casA 74  
XP_003197868   42 INFQEKNDKKRKQEEAIKRgee-----------------------vvtEGKHLRMGSMSMPAPAEHMsphqhq-hpcnpG 97  
XP_029686357   42 LFLQEKNDKKRKKEEAIKRTged----------------------iatEGKHLRIGSITMPEPQERMpiplpqalacgqA 99  
XP_023207578   50 TYLQEKHQKKRRQEEAIKRIgedvat----------------asdgaySGKHFRMGFMTMPAPQDRVptp-------tpG 106 
KAG9264817     48 AYLQEQSQKKRRQDEAIKRMgedvgsm---------------adggayAGKHFRMGFMTMPAPLDRLppp------sgpG 106 
ELK17147       51 AYLKEKNEKRRRQEEAIKRIggevgr----------------ghegsyVGKHFRMGFMTMPAPQDRLphp------cssG 108 
XP_015217256   50 AYLQEKSEKKRRQEEAIKRIgedvar----------------atdsgyVGKHFRMGFMTMPVPQDRLphp------cgaG 107 
XP_422618      51 AYLKEKSEKRRKQEEAIKRIggevvr----------------gnegsyVGKHFRMGFMTMPAPQDRLphp------cssG 108  chicken
XP_041420884   51 AYLKEKHEKRRKQE-VIKRIggevar----------------gtegsyVNKHFRMGFMTMPAPQDRLphp------cssG 107  African clawe...
XP_049331236  108 MAPRSQSCHAV-------GTGEGEslenGDYPDSDTQstpntsrcPPAKPKRHPSTRLSSTPQQEH--PARgSHGPP-DA 177 
4_pfamImport   75 MAPRSQSCHAV-------GAGDTSle-nGDYPDAQSQhcg---rcPPTKPKRHPSTRLSSS--D--------GRG-LlDM 132 
XP_003197868   98 FSVRSQSLHSV-------GGLEEE-----GSPTSRKQ--------PPPKPRRDPSTKLSISSEAVDisPTY-CKGDEsER 156 
XP_029686357  100 FSVRSQSLHSVggggnsgGGGDEE----VGSPTSRKQ--------PPPKPRRDPATKLSMSSEAVD--HSP-MSTCRgDR 164 
XP_023207578  107 FTVRSQSLHSV-------GGGEED------SNHSRKQ--------PPPKPKRDPTTKLSSSSEAVDgvSGF-IKREYqEA 164 
KAG9264817    107 FTVRSQSLHSV-------GGGEEEg---GGSPTLRKQ--------PPPKPKRDPNTKLSTSSETVN--ATL-STGKGgKE 165 
ELK17147      109 FSVRSQSLHSV-------GGTDDD-----SSCGSRRQ--------PPPKPKRDPSTKLSTSSETVN--ST--ATSKSgKA 164 
XP_015217256  108 FSVRSQSLHSV-------GGGDED-----SNVNSRKQ--------PPPKPKRDPSTKLSTSSETVN--TG--TTCKAgKD 163 
XP_422618     109 FAVRSQSLHSV-------GGTDDE------TSSSRKQ--------PPPKPKRDPNTKLSTSSETVN--TG--TTSKSgKL 163  chicken
XP_041420884  108 FSVRSQSLHSV-------GGTEDD-----SSGCSRKQ--------PPPKPKRDPNTKLSISSETVN--FG--TLGKSpKF 163  African clawe...
XP_049331236  178 Ppppppq--nskhseKKNAMKKSDSGEMQGRKVPPQKPKRSPSTQL--SFDPPPPRvppp-----------atpLPFQSA 242 
4_pfamImport  133 PpllasshsqtkhseKKNAMKKSDSGEIGGKKVPPLKPKRSPSTQL--TFESLPPRvphs-----------atpLPFQAA 199 
XP_003197868  157 Cd------------gTQ-------GCSEDCRKVPPPKPKRNPNTQLstSFDEsyirsng-----------skgsttmLFS 206 
XP_029686357  165 C--------------------DAQGCSEDCRRVPPPKPKRNPNTQLsvSFDEsyikshgsgaicpskhlhrvvsPSELNA 224 
XP_023207578  165 Kd------------gAELSEARYHHHSEESRKMPPPKPKRDPNTQLssSFDEsyvrnhc---------skkssfQGDKSS 223 
KAG9264817    166 Td------------kSD-ASKSRPCSEEY-RRMPPPKPKRNPNTQLstSFDEsyirnhgtk----fksaslprrQKKKSA 227 
ELK17147      165 Pe------------rTEVSTKPRPHSDEYSKKIPPPKPKRNPNTQLstSFDEtyikkhg---------prrtslTRDSSL 223 
XP_015217256  164 Ld------------rSDVSSKPRPYSEEY-KKIPPPKPKRNPNTQLstSFDEsyirnh----------gtrksaKKETSS 220 
XP_422618     164 Pd------------rTEVSAKPRPHSDEYTKKIPPPKPKRNPNTQLstSFDEtyikkhg---------pmktplTRDASL 222  chicken
XP_041420884  164 Td------------rTDISAKQRPHSDEYTKKIPPPKPKRNPNTHLstSFDEtyikkh----------gsmkstLFRESS 221  African clawe...
XP_049331236  243 DPSPH---GEGGDDEPVYIEMVG-QVFTREtsgaqtphpltpsaTTPDSDSDQGEAIYEEMKYPIAEDaarDAQRRLPPK 318 
4_pfamImport  200 DSQIQ---KRDGEDEPVYIEMVG-QVFTREsqtatph-pvtpvaTTPDSDSDQSEAIYEEMKYPQSKAtvsISHSSPLPS 274 
XP_003197868  207 RDGQTpspQPQDLDEPVYIEMSG-NVGQEAt--------------pRTEEDEPGEAVYEEMKYPALDE------------ 259 
XP_029686357  225 SPQSDespTDDCEDEPVYIEMGGiDVGSREp--------------lKSEDEEPGESVYEEMKYPALDD---------MEY 281 
XP_023207578  224 SQSHSpasRDTDDEEPVYIEMVG-NILRELk-------------gQEAVDDEQSESVYEEMKYPMLED------------ 277 
KAG9264817    228 SQNQSpalDTDEEAEPVYIEMVG-NILRDFnqi---------tgGHADEEDNQDESVYEEMKYPMYDE-----------V 286 
ELK17147      224 SQASSpagDPEEE-EPVYIEMVG-NILRDFr----------------kEDDDQSEAVYEEMKYPIFDD------------ 273 
XP_015217256  221 SQTHSparDTDED-EPVYIEMVG-NILRDFr----------------rDDEDQSEAVYEEMKYPIFDD------------ 270 
XP_422618     223 SQVSSpapDTEEE-EPVYIEMVG-NILRDFk----------------kDEDDQSEAVYEEMKYPIFDD------------ 272  chicken
XP_041420884  222 SSHISttaLDREDEEPVYIEMVG-NILRDFk----------------rDDEDQSEAVYEEMKYPIFDD------------ 272  African clawe...
XP_049331236  319 -HRSA-----KAYHHSSSISSSSSss-lPRPASSSPSCPSssskpkatvsishssplpsstssasstpvplqplstsphp 391 
4_pfamImport  275 sASSTpvlqvLSTSPHTPRAPTPYllqgTKSESESNT------------------------------------------- 311 
XP_003197868  260 ----------YD--------SRWDlv-nCRSLCVTPCPSEseiytplsr------------------------------- 289 
XP_029686357  282 -RTDP-----VGCRSACP-TPAPYdp-ePLSRCSTPRNIP---------------------------------------- 313 
XP_023207578  278 ----------FLQDVQ-STIIDSE---------AWSSRGS---------------------------------------- 297 
KAG9264817    287 -APPA-----DQAQSRWEPCPTSAvp-dVELTRPSTPRGS---------------------------------------- 319 
ELK17147      274 ----------LGQDSK----CDLDhh-sCSSQCATPTVPDldfakssv-------------------------------- 306 
XP_015217256  271 ----------LGQDSKWSSIYNSDhi-sCSSQCATPTVPDlelakppv-------------------------------- 307 
XP_422618     273 ----------VGQDSKCQ--CEYDhh-tCSSQCATPTVPDldftktsv-------------------------------- 307  chicken
XP_041420884  273 ----------IVQDSRCL--YEVDhi-sCSSQCATPTVPDleftkssv-------------------------------- 307  African clawe...
XP_049331236  392 praptpfllpgtkseseigsSSKIPAPFPNLLQHKPPLLAFPQP---------AAASSGISAQHKSSSAKSGNSSGQA-- 460 
4_pfamImport  312 ----------------------KIPAPFPNLLQHRPPLLAFPQP---------AAASSGVGVQNNVPSSLS-GSKES--- 356 
XP_003197868  290 ------------cttprgvpLCDIPAPFPNLLSHRPPLLVFPPApaqcspnsdESPLTPLDVAKLPMFE-NGSFGKSPt- 355 
XP_029686357  314 --------------------LCDIPAPFPNLLTHRPPLLVFPPApaqcspnsdESPLTPLDVTKLPMLE-NQSYSKSP-- 370 
XP_023207578  298 --------------------FCDIPPPFPNLLTHRPPLLVFPSApvqcspnsdESPLTPLDVTRLPMLE-NVSLSKSG-- 354 
KAG9264817    320 --------------------LCDIPAPFPNLLTHRPPLLVFPPApaqcspnsdESPLTPLDVTKLPMIE-NVGYVKPGs- 377 
ELK17147      307 -------------pctpkglLCDIPPPFPNLLSHRPPLLVFPPApvqcspnsdESPLTPLEVTKLPVLE-NVSYMKQQag 372 
XP_015217256  308 -------------pstpkgtLCDIPAPFPNLLSHRPPLLVFPPApaqcspnsdESPLTPLEVTKLPVLE-NVSYIKQSga 373 
XP_422618     308 -------------pstpkglLCDIPPPFPNLLSHRPPLLVFPPApvqcspnsdESPLTPLEVTKLPVLE-NVSYIKQQag 373  chicken
XP_041420884  308 -------------pstpkgqVCDIPPPFPNLLSQRPPLLVFPPApaqcspnsdESPLTPLEFSKLPVLE-NVSYIKQQgs 373  African clawe...
XP_049331236  461 --PSSLPPnags-------sssKESSGGEKDREKDRKD-GHLGPAPGLRARSHSTPLPpssk----------sssPY 517 
4_pfamImport  357 ---GGSSS--------------QQDKNSRDAQWGPA---------PGLRARSHSTPLPpssk----------stsPL 397 
XP_003197868  356 --SSSLEPsg-----------sASTSHMR-----RAEReLTATPTITASGRS-SAPPLpcalyks---ssssysyQR 410 
XP_029686357  371 --TSSAEP--------------PPSAHLR-------RE-LTATPTLTVSGRS-SAPPLpctlyk-----sssssyQR 417 
XP_023207578  355 ---GAEHP--------------QGSGHHRKDRDRDRDRdASHTHTITSSGRS-SAPPLassfykssssahsvhgyPR 413 
KAG9264817    378 -sPTAGDPgqpvpeqpkpsghhHHHHHHHHKKSSDSKE-GSSTHTITVSGRS-SAPPLpsalyksg-gssaahgyPR 450 
ELK17147      373 asPSSLPS--------------HSSGHPKLEKD-QSGAlGPA---PATSVLS-SSPPPpstlyrt----qsphgyPK 426 
XP_015217256  374 -sPSAASS--------------QTSIHQKIEKELPPTQt------ITASGRS-SAPPLpstlyks---sasahgyPR 425 
XP_422618     374 asPSSLPP--------------HTPGHQKLEKEQMVSH-G-----TSTPGHT-SSPPHpstlyrt----qsphgyPK 425  chicken
XP_041420884  374 psSS---S--------------HIPGHQK----VEKDP-TIVSHGTSSSGHSQSSPPHsstmyrt----qsphgyPK 424  African clawed frog
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