Conserved Protein Domain Family
SVWC

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pfam15430: SVWC 
Single domain von Willebrand factor type C
SVWC is a family of single-domain von Willebrand factor type C proteins from lower eukaryotes. The canonical pattern of most von Willebrand factor type C (VWC) domains is of ten cysteines, however this family, largely but not exclusively of arthropod proteins, contains only eight. SVWC family proteins respond to environmental challenges, such as bacterial infection and nutritional status. They also are involved in anti-viral immunity, and all of these functions seem linked to SVWC expression being induced by Dicer2.
Statistics
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PSSM-Id: 495094
Aligned: 80 rows
Threshold Bit Score: 39.6881
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002426862  51 CT----TVEPGKSWDLTPFCGRSTCVVaegeqAGRLLelVEDCGPLPKAn--PKCKLSektNKTAPFPDCC-PIFEC 120
EEC00634      37 CIwkkyVIPDGGHLNLANPCISLTCDGk----LKYLR--GASCGRIAHEgipKNCTLG---KGKGIYPKCCkTQLTC 104
EEC13907      34 CKygnhLIADGASLNLENPCQTFYCNAq----LGTIS--SLGCALMPNP---SNCRVY---KGTGPYPKCC-NQINC 97 
EEC03776      38 CKyknrLVADGASLRFENPCQSWTCDVr----SRSFA--ILPCGIIANP---MNCPVF---KGTGPYPSCC-YEVNC 101
EEC09428      37 CTyenhTVANGESLKWADPCQTWECNVe----ERSFA--VLGCGLVANP---SGCELV---RGTGPYPDCC-YRAVC 100
EEC19195      37 CKwgnyLVPDGESLNLEDPCQTWQCSVe----DRSFA--VLGCGLIGNP---YNCEIV---RGTGPYPNCC-YRTNC 100
XP_029843190  37 CFfnnvTIEHGTAHLSENPCESWRCDAt----TLDIT--IFGCGVVGVG---EGCRLI---PGHGVYPECC-PQLTC 100
EEC18330      37 CTyrniTLKDGHSDNFQYPCEFWTCNAt----AKTLT--VEGCGVARYG----SCRYVh--HPRFYWPHCCrMTRVC 101
EEC08568      37 CTyrniTLKDGHSEPFKFPCEYWSCNAt----AKTLT--IDGCGVPRYG----SCLYVh--NYNFYWPLCC--RMSR 99 
EEC07391      37 CAydghLLSHNSALDRQSPCEKVICDTe----QRVVY--IGLCSPVANP---ENCEIR---TRDERYPYCC-PQPYC 100
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