Conserved Protein Domain Family
S100PBPR

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pfam15427: S100PBPR (This model is not part of the current CDD release)
S100P-binding protein
S100PBPR is a family of proteins found in eukaryotes, and localised to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.
Statistics
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PSSM-Id: 521840
Aligned: 12 rows
Threshold Bit Score: 577.592
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008271965  21 NASFS-WS--SLDEEELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDPSD---VCGEGLYKDDGGHVE--NGGKGNQI 92 
2_pfamImport   1 SVPFS-WS--SMDEDELDDSLLELSDGEEDDGHFSFTEEEIEMLLQDDDLSDeqsSGRRDLLKDDSGHIE--KGERESQI 75 
XP_006158161  21 SAPFS-SS--SLDEDGLDDSLLELSDGEEDDGHFSYTEEEIEELLKDDDLLDehiPREAGLCKDDSGRDE--KGERGGHI 95 
XP_005617682  21 NAPFS-WG--SLDEDGLDDSLLDLSEGEEDDGHFSFTEEDIQELLKDDDLSNehfSWGGGLLKDN-RHVE--KGGKGNEI 94 
Q3MHH3        21 NAPFS-WS--SLDEDELDDSLLELSDG-EDDGHFSFTEEQIQELLKDDDLSNehfPWGGGLPSDDSRNVE--KGEKGSQI 94  domestic cattle
XP_031818158  29 NVPISsWGrfGLDEDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNeqsL--GGLRKDTGGDPE--KLGSCSCA 104
XP_001164617  21 gAPFS-WD--CLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYeqsSGE-----DDGGHVE--KGERGSQI 90 
3_pfamImport   1 NAPFS-WG--SLDDDVLDDSLLELSDGEEDDGHYSYTEEEIEELLKIDEPSSedhSWEGGLCKDESRHDE--KGERGSQI 75 
NP_001128100  21 NASFS-WG--SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD----------------GGHNE--YRARKSQI 79 
XP_013219442  21 tAPFS-WG--SLDEDELDDSLLELSDGEEDDDNFNYTEEEIDELLKDDDPSDehfSLEERLCKDDGRHVE--NGGKGSQV 95 
EHB04568      21 NAPFS-WS--SLDEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNeeeIEE--FLKDDEPSNEhaNGEKRSQI 95 
XP_056651278  30 DPVSS-WGrfGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNeqslgglrkdt----ggqaeklenysCI 104 gray short-tail...
XP_008271965  93 LPDTPQEKnsNSLCSLGPVTETPGLFKLPQLNTSVGHGPTPAKPLNRRFALEKNLIKVTiVAPFNPAACDTVREKKKV-- 170
2_pfamImport  76 LLDAPQEK--NSLYSLGPVAETPGLFKLPQLSTSIGHGSTPTKPLNRRFALEKNVIKIT-VAPFDPTVYDAVLDKDKT-- 150
XP_006158161  96 LLDIPQEK--NSLYSLGPVTETPDLFKLPQLSTPVGQRPTPNKPLNKRFILDKNLIKVT-VAPFNPTVCDAVLDNDKT-- 170
XP_005617682  95 LLDTSQEK--NSLYSLGPVAETPGLLKLPQLSTSVGNGPTPTKPLNRHFALEKNLIKITvVAPFDPTVCDAVLDKDKT-- 170
Q3MHH3        95 PLDTPQEK--DSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVT-VAPFDPTVCDVALDKDKTyv 171 domestic cattle
XP_031818158 105 SFDSPQDI--NVLCSLGPRAGPASIHKLPQISTPASHAPS-----SRHFVPEKSLLKITvVPPFNSTVCDDMLGPKKTe- 176
XP_001164617  91 LLDTPQEK--NSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT-VAPFNPTVCDALLDKDET-- 165
3_pfamImport  76 LLDTPQEK--NLLYSLGTVAETSG-FKLPQLSTSIGHGPTPTKPLNRRSAVEKNLIKVT-VAPFNPTVCDAVIDKDQT-- 149
NP_001128100  80 LPHTPQE---NSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVTvVAPFNPTVCDPVLDKDKI-- 154
XP_013219442  96 LLETPQEK--NSLYNLRPVAETPGLFKLPQLSTSVGHGPIPTKPLNRRFVLEKNLIKVTvVAPFNPSVCDPVLDKDKI-- 171
EHB04568      96 LLETPQEK--SSLYSLKPVAETPGLFKLPQLNTTVGHEPIPAKSLNRHLVLEKNHIKVTvVAPFDPTVCDPVLDKSKT-- 171
XP_056651278 105 SFDSPQDI--NVLCSTGPRAGPASIHNLPQKNIPARHAPIPTKSPSRHFVSEKNLLKITlVPPFNTTVCDA-FGPKETe- 180 gray short-tail...
XP_008271965 171 --NSSKETEK-------PSPTGEEMR-NGLTPNEGEACTESEGISPSNSSWEQPQLSS--NSNVQLTVSGKNLPDCKKPT 238
2_pfamImport 151 --DSSKDIKK-------PSSLGEELReDGLNTNESKLCTESEVISPTNSAWDGHTFPSpsNNNFQETVSDKNMPDSKKPT 221
XP_006158161 171 --DSSKDTEK-------PSSLGEDT---SYNPDENKLCTESEDISPNNAAWDEPLFSSplNNNFQNTVSDKNIPDSKKPA 238
XP_005617682 171 --DSSKDTEK-------PSSLGEEMRkGGLSPNENKLCSESEGISPSNSAWDAPPLSSpsDNDFEQTVSDKNMPDSKRPT 241
Q3MHH3       172 seVTSRVTEK-------PSSLGEEMReDDLSPNESTLCTESEGISPDNSASDGPPLPSs-NSNFQHTVSDKNMSDSKKAT 243 domestic cattle
XP_031818158 177 --FSSKDGSSnay-ylgISSLKEDVSkEDHGQNDGKLCTKE--ISSTCSVWEGPQp---hKAGPSQGAPRASGPSCEESV 248
XP_001164617 166 --DSSKDTEK-------LSSLGEEMReDGLSPNESKLCTESEGISPNNSAWNGPQLSSs-NNNFQQTVSDKNMPDSENPT 235
3_pfamImport 150 --DSSKDTEK-------SSSLGEKLKeDGLSSNESKLCTDSEGIRPSNSAWERPSLSStsNNTFQQTVSDKAVPNSKKPT 220
NP_001128100 155 --DSSKETEK-------PASLQEQTReDDLHPNESKRCTEPEGVSPNNSAWDGPLLSSpsNNNIEQTASDKNIPESKKPT 225
XP_013219442 172 --DSSKDTEK-------PSSLEEGMReDGLNPNESELCTESEEMSPNNSAWDGSLFSSplNNNFQQTISDKNTPDSKKST 242
EHB04568     172 --DSSKDTEK-------LSSLGEEMReYDLTPNESKVHTESEEISPNISAWDG--ISSplNSNFQQTVSVKNTLDSKKPT 240
XP_056651278 181 --SSSKDGSSnanclgtPSSLEKDVNrEGHGQNDGKLCTKE--ISSACSVWKGTPp---pKAGPPQGPPRANTPICEESV 253 gray short-tail...
XP_008271965 239 PVFSQLSDHPETPN-AESPWRNGGSHRSSCEVKFS-VSSSP-NKD-VFDKDSGKMKVHEKRLGKVIPVLQTKTRTNVSTF 314
2_pfamImport 222 PVFSQVLDHSESSSyMGSSYRNGGSHKSSCEVRFPvVSSSE-KKQhVLDKDSGKMKVHERRLGKVIPVLQSKTRTNVPMC 300
XP_006158161 239 SVFSQISDHSETPFnTGSSWRNGTSHKSSCEVRFPvISNSS-NKD-IPDKVSGKVKVSERRLGKVTPVLQTKTRTNVTTF 316
XP_005617682 242 PVFSQILDHSETPN-TGSSWKN-GSHKSNCEVRFPvVSSSS-NKQdVLDKDSGKLKVNERRLGKVIPVLQAKRRTNVPTF 318
Q3MHH3       244 PVFSQILDHSETPN-TGSSRRN-GSYKSSFEMKLP-VSSSS-SKD-VLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTF 318 domestic cattle
XP_031818158 249 PLASPTLEQSQRQE-VALSSGNGG-HKLGD------ASVHS-TKLvRLDMDSEQKEGYERRLGKVIPLLQARARSKIQTF 319
XP_001164617 236 SVFSRISDHSETPN-MELSCRNGGSHKSSCEMRSLvVSTSS-NKQdVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTF 313
3_pfamImport 221 PAFSQISDHSETPS-VGSSWRNGGSHESSGEMKFPvSSSSNkKKQdVLDKDSGKIKGNERRLGKVIPVLQTKARTNVPTF 299
NP_001128100 226 PVFSQISNHSEVPN-----RKNSGSHKSGCEVRIPvVSSSS-NRH-AFDKDSGEAKG-ERRLGKVIPVLQTRTR----MF 293
XP_013219442 243 PVFSQISEHSETPN-MGSSWKNGGSQKSSCEMRFPvVSSSS-NRD-ILDKDSGEMKVRERRLGKVIPVLQTKTRTNVSTF 319
EHB04568     241 PVFSQISDHSKTPSsTSSSWKNSGSHKLSCEMRSPvVSSSS-KRD-AFDKDSGEMKGREKRTGKVIPVLQTKIRTNVSTF 318
XP_056651278 254 PVASPTLGPTPRPD-VALSSGNDG-HKLGDTARSPaVQSSS-TKPvKLDKDSKKKEGYERRLGKVIPLQLakarskiqTF 330 gray short-tail...
XP_008271965 315 SQSDLEQQKQIYLRRVIAHIQDPVDSNQGALGELYALMDQV----HHMQNPKRQHPSDLTMRNYARYRQNPPQRYSLTQW 390
2_pfamImport 301 SQSDLEQQKEIYLRSVIAHIEDPVDPNQGALGELHALMDQV----HHTQNQKWQHPSDLTMRNYARFRQKSLQRYSLTQW 376
XP_006158161 317 SQSDLEQQKQIYLRSVIAHIEDPVDSNQGPLGELCALMDQV----HYTKNQKWQHPSDLTVRNYARFRQKPLQRCSLTQW 392
XP_005617682 319 SQSDLEKQKESYLKEVIAHIEHPKDTNQGALGELYALMGQV----HHMQNPKWQHPSDLTMRNYARFRQKPLQRYSLTQW 394
Q3MHH3       319 SPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQV----HHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQW 394 domestic cattle
XP_031818158 320 SQTELEQKKQIYLKNVIAHLKHPLESNQGTLGEFYALMDQVanveYHMQHQRWQHPSDLTMRNYPRFRQKPLLRYSLTQW 399
XP_001164617 314 SQSNLEQQKQLYLRSVIAHIEDPEDTNQGVSGELCALMDQV----HHMQHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQW 388
3_pfamImport 300 SQSNLEQQKQIYLRSVIAHIEDPEDSNQDVAGELYTLM-EV----HHMQNPKWQHPSDLTMRNYAR-RQKPLQRYSLTQW 373
NP_001128100 294 SQSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQV-----HMQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQW 368
XP_013219442 320 SQSDLEQQKQIYLRSVFDHIEDPGDSNQGTSGELYALMNR-------------QHPSDLTMRNYARFRQKPLQRYSLNQW 386
EHB04568     319 SQSDLEQQKQIYLRRVFDHIEDPGDSNQGPSGELYTLMDR-------------QHPSDLTMRNYARFRQKPLQRYSLTQW 385
XP_056651278 331 SKTELEQKKQIYLKNVIAHLKNPLESNQGALGELCALMDQVangeYQKQNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQW 410 gray short-tail...
XP_008271965 391 VDWNKRSYHRFQHL 404
2_pfamImport 377 VDRNMGSHHRFQHL 390
XP_006158161 393 VDRNMRSYHRFQRh 406
XP_005617682 395 VDRNMRTHHRFQRL 408
Q3MHH3       395 VDRNKRSHHRFQRL 408 domestic cattle
XP_031818158 400 VDRNLRSHRRFQGL 413
XP_001164617 389 VDRNMRSHHRFQRL 402
3_pfamImport 374 VDRNMRSHHRFQRL 387
NP_001128100 369 VDRNKRSHHRFQRL 382
XP_013219442 387 VDRNKRSHHRFQRL 400
EHB04568     386 VERNKRSHHRFQRL 399
XP_056651278 411 VDRNLRSHRRFQGL 424 gray short-tailed opossum
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