Conserved Protein Domain Family
Joubert

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pfam15392: Joubert 
Joubert syndrome-associated
This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.
Statistics
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PSSM-Id: 495066
Aligned: 11 rows
Threshold Bit Score: 340.265
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGV97562      205 QLQVTGLTDIADIIDDLITKSGVSSEELGLTKKQARNISRI---QQSS-GRCPQRTEEERREIKIWMKRKRKERMAEYLN 280 
5_pfamImport    1 PLQMAGLTDIADIINDLITRGGVSSKELGLTEQQARSISRI---QHSS-GRCPQRTEKERREIRAWMKRKRKERMAEYLN 76  
1_pfamImport    1 PFQMTGLTDIADIIDDLITKDGVSSDELGLTEQQTRNISRI---QHSS-GRRPQRTEKERREIQAWMKRKRKERMAEYLN 76  
Q8CE72       2894 QLQVTGLTDIADIIGDLITKSGVSSHELGLTECQARSISRI---QRPP-DRGPRRTAEERREIKAWMRRKQKERMSEYLG 2969 house mouse
2_pfamImport    1 PLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRI---QPSS-GRRPQRTEEERREIQVWMKRKQKERMAEYLN 76  
XP_059734875 2906 PLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRM---QHPS-GRRPQRTEKERREIQVWMKRKRKERMAEYLN 2981
3_pfamImport    1 PLQMTGLTDIADIIDDLITKDGVSSKELGLTEQQARSISRI---QQSS-GSRPGRTAKERREIQVWMRRKRRERMAEYLH 76  
4_pfamImport    1 PLQMTALTDIVDIIDDLITKDGVSSEELGLTE-QAKTISRI---QHTS-GRHPQ-------EICIWMKKK-KERMAEYLH 67  
6_pfamImport    1 SLRSDQNTAFPDIIDDLITKGGVSSEELGLTEQQARRISRV---QHSY-SRRPQRTEKEKREIRVWMKKKRKERMAEYLN 76  
XP_031820080 2871 DFQITGLTDVADIIGDLITESGVSREELGLTEHQAMKISRI---HSTPkKRKSQRTEKEKREIRAWMKRKRKERMAEYLA 2947
7_pfamImport    1 TLGLSGLSDIADILGELVRGGGVSASALGLSETQAIRLSRAgaqQRWQpGRKVRRSERERREVREWMRRKQRERLSEFHR 80  
EGV97562      281 QLAEKRGQERDPFCPRNSPFYMTSRQIRQRQKMKHEKDRLLLSNHYSQRISEAYHLMNELLSDSVQLTAPAD---QPLPN 357 
5_pfamImport   77 QLAEKRGQEHDPFCARSNPFYMTSKEIRLRQKMKHEKDRVLLSDHYSRRITQAYSLMNELLSESVQLPVTAQ---KPSPN 153 
1_pfamImport   77 QLAEKRSQEHDPFRPRSNPFYMTSREIRLTQKMKHEKDRLLLSDHYSRRISQAYSLMSELLSESAQLPAAAQ---KPLPD 153 
Q8CE72       2970 QLAERRGRERNPFCPTSSPFYMTSRQIRQRQKMKREKDRLQLSKHYSQRLSQAYSLMNELLSDSAHITAPAE---NPLPP 3046 house mouse
2_pfamImport   77 QLAEKRGQEHEPFCPRSRPFYMTSREIRRRQKMKHEKDRLLLSDHYSRRISQAYSLMNELLAESVQLPATVQ---KPLPN 153 
XP_059734875 2982 QLAEKRGQEHDPFCPRNNPFYMTSREIRLRQKMKHEKDRLLLSDHYSRRISQAYTLMNELLSESVQLPAAAQ---KPLPN 3058
3_pfamImport   77 ELAERRGQEHDPFCPRSNAFYMTSREIRLSQKMKHEKDRLLLCDHYSRRISQAYSLMNELLSESVQVPA--Q---KPLPS 151 
4_pfamImport   68 QLAEKRGQEQASFCPRNNPFYTISREIGPRQKVKYEKDRLLLSDHYSRQISQAYSL----------LPTTAQtqmQQLPN 137 
6_pfamImport   77 QLAEKRGQERDPFCHRSNPFYMTSREIRLSQKMKHEKDRLLLSDHYSRRISQAYSLMNELLSESVQLPATAQ---KPLPN 153 
XP_031820080 2948 QLAQKREQEYEPFQPQRHPLCMTSKEIRLCQRMKNEKDRLQLSEHYDRRVAQAYSLMNELLFESAQVPRRCL---KKPPG 3024
7_pfamImport   81 QREERRQREHRPFAADSVARSPTSKDISISQKIKEEKDKAALLEHHSRRTREALRLMDEMLTDTVPLPTAHP---PSLAH 157 
EGV97562      358 RP---PTAQHYRQQHCSSPRRENPHGQNFLINRPGRGRHIS-RSSRLQKGKPLEQSKGS--------------------- 412 
5_pfamImport  154 KP---STAWHSGQQCCPSPRREYHHGHNFLINQPGKVKCIS-KSSHTHKGKTLEPSQDShwrcgaanfpiekraggakea 229 
1_pfamImport  154 RP---RTAHTSRRQRSLSPRGENRHGHNFPINQPGKVRNIS-KPSCTPKGKPLGQPHGSpwprgtatftiqkksggakma 229 
Q8CE72       3047 GP--------YRRQRGSSPKRENAHGQSLPVNRPGGDRHIS-RSSHLCKGQPRGSSQ----------------------- 3094 house mouse
2_pfamImport  154 KP---RTTQIPRRQRSLSPRRENQHGHNFPIHRPGKTRYISsKPSYTPKGRPFGHPQGSpwp------------------ 212 
XP_059734875 3059 -----RKAHIPRRQLSPSPRGENRHGHNFPIYRPGKVRHTStKPSYTQKGRPFGQSQGSpwpretatfttqrkagaakmv 3133
3_pfamImport  152 KP---RTVHTCRLQSSLSPRRETRYGHNFPVNRPGKVRNIP-KPSYIPKGKSFGQPQGSpwphgtitftqkkag-garga 226 
4_pfamImport  138 KR---RTAQVSKQQRFPCPNRENQHGNNFPINRRGKVSCIP-KSSYTQKGKPFVQPQDSp-------------------- 193 
6_pfamImport  154 KR---STAQSSRWQH-------------YPRGKLKQFVFIG-TATFTIQKKGggvkaavr-------------------- 196 
XP_031820080 3025 SPa--KSARISRKQYHLPPKGEDRNINTLSPNRNSKVRFAS-KPTYIHGRTPLSQHQHPsqrnrkaat------------ 3089
7_pfamImport  158 TPgrsSRSQSAGR----TGRRPSQAGQARSLSSPGRTQLFT-ESTRLMRSTECVRSR----------------------- 209 
EGV97562      413 ---------SRRQGSNTSCqsLL---------HTNSR---GVAPPKKQVCIEYEREDTVVSPWTLPSEIHRILHDRPKTL 471 
5_pfamImport  230 lrkavqspvTFPTGSHAPC--LQ---------HTKKHrsaGLAPQTTQVRIEYEREETMTSPWTLPPEIHRILHETPGSL 298 
1_pfamImport  230 vrkavqspvTFQKGSRAPCcsLQ---------HTKSRa--GLAPQTKQVCIEYEREETVVSPWILPADIRQVLRESHSSL 298 
Q8CE72       3095 -----------LRGSQPPCqsQK---------PLRSRgaaGVGPPVQQACREDEREEMVVSPWTLPSEIHRILHGRPESL 3154 house mouse
2_pfamImport  213 -------------------------------------hgaGLAPHTKQVCLEPEREEMVVSPWLVPPDIRALLRRSQSSL 255 
XP_059734875 3134 vrkvvqspvIIRKGPNAPC--QH---------CIKSHrsaGLAPQTKEVCIEYEREETVVSPWLVPSDIRAILHESHSSL 3202
3_pfamImport  227 rrkavhspvTFRKGSTAPC--LQ---------HSKQHgsaGLGPHTEQVCAEDEREETVVSPWLVPSDIRRILHGSHSSL 295 
4_pfamImport  194 ---------CLQKGSDAPYcsLQ---------HTKNYg--------tKRCVEYEREETVLSPWTLPSEIHKILHDSHDSL 247 
6_pfamImport  197 --kavkspvTFQKDSNAPYhsLQ---------QIKNHksaGLAPQTKQVCIEYEREETVVSPWTLPSEIHKILHESPSSL 265 
XP_031820080 3090 -svkkttevTRKPARNVSCfsDLssqdfsyppRRTSYvksSETSTSTTNAEEYEREHDKMSSWTMADHADRILCRGPWSS 3168
7_pfamImport  210 -----------LAASALPRdrMS---------QLTRRgmvSDPDPDAWRSRRGDRERAAPVHSRDPSLFHSGLIHLPQGL 269 
EGV97562      472 LQDISPAEEEepeSSVLVAGMDSVSESTGSILSKLDWRAIEDMVADVEDKNLP 524 
5_pfamImport  299 LQDLSQEEPE---PHFGVAGMHSMSESTGSILSNLDWNAIEDMVASVEEKNLS 348 
1_pfamImport  299 LQDLSPTKEEp-kPPFEVSGMDSMSESTGSILSKLDWNAIEDMVASVEDKSPS 350 
Q8CE72       3155 LQDMSPADEEepePPLLAGGMDSVSESTGSILSKLDWKAVEDMVASVEDKNLS 3207 house mouse
2_pfamImport  256 LQVSVVPDCT---LLDSVGGPDSLSASTGSILSKLDWDAIEDMVADVEDKSHL 305 
XP_059734875 3203 LQDSSPTEEKs-eAPLGVGGTESLSESTGSILSKLDWDAVEDMVAGVEDKSLS 3254
3_pfamImport  296 PQDLSPTEEEp-aSPTGEGGMDSVSESTGSILSKLDWNAIEDMVANVEDKSLS 347 
4_pfamImport  248 LQSLSPPEEEk--PSAGVSGMDSRSEGIGSILSKLDWNAIEDMVARVDDKHLS 298 
6_pfamImport  266 LQDLSPAEEEqprTPFGMGGMDSMSESTGSILSKLDWNAIEDMVASVEDKSLS 318 
XP_031820080 3169 LEDFSPAEDEk--FSVSINGLTSGSESTSSILSKIDWRAVDNMVAMVKN---T 3216
7_pfamImport  270 SGNRSPLRRA---DLDGLNELDALSDSTGSILSKLDWAAIENMVASEGDVEIA 319 
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