Conserved Protein Domain Family
WDCP

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pfam15390: WDCP (This model is not part of the current CDD release)
WD repeat and coiled-coil-containing protein family
This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC). WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients.
Statistics
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PSSM-Id: 521822
Aligned: 24 rows
Threshold Bit Score: 1112.02
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002188893   2 DLGKAKLLRTGLNALYQAIHPVHGIAWTDGKQVILTTLYYQNGELKFGDSSILGQFEHVHGLSWGPYCSTDTPALLAVQH 81 
XP_007477992   2 DLGKGKLLRTGLNALHQAIHPIHGIAWTDGKQVVLTALQLQNKEPTFGDSRIIGQFEHVYGLSWGPVGSEGTPTLLAIQH 81 
Q5ZKI7         2 ELGKAKLLRTGLNALHQAIHPVHGIAWTDGKQVILTSLHLHNGEPKFGDSSVVGQFEHVHGLYWGP-GPPDAPALLAVQH 80  chicken
XP_003215426   2 ELGKGKLLRTGLNALYQAIHPVHGIAWTDGKQVILTSLYLHNGEPQFGNSNVVGQFEHVHGLHWGPSCASDLPALLAIQH 81 
XP_008115227   2 ELGKAKLLRSGLNALYQAIHPMHGIAWTDGKQVALTALHYHNKELKFGESTVIGQFEHVHGLYWSPHHSANTPALLAVQH 81 
XP_069055211   2 DLGKAKLLRTGLNALHQALHPVHGIAWTDGKQVALTALYWANGEPKFGDTNVIGQFDHVLGLFWGPVCCTGSPALLAVQH 81 
XP_040015976   2 DLGKAKLLRSGLNALHRATHPVHGIAWTDGKQVCLTSLFFVNGEVTFGDTNVIGQFEHVLGLSWGPLCCSDSPALLAVQH 81 
4_pfamImport   1 DLGKAKLLRTGLNTLHQAIHPVHGIAWTDGKQVCLTSLYFINGDVKFGDTNVIGQFEHVFGLFWGPLCCSDSPALLAVQH 80 
XP_007229773   2 DLGKAKLLRTGLNTLLQAIHPVHGIAWTDGRQVCLTSCYFVNGDPKFGDTNVIGQFEHVLGLFWGPLCCSGSPALLAVQH 81 
Q5RFV8         2 ELGKAKLLRTGLNTLHQAIHPVHGIAWTDGKQVCLTSLFSVEGEPKFGDTNVIGQFEHVLGLFWGPLCCSGSPALLAVQH 81  zebrafish
XP_002188893  82 KKHVSIWQLVYSSAEKKKPLISQTCEVGEPFPLLSQGCVWHPKKEVLAVLTKRDASVLHAVRTDNTRVKAE-IKSSGVIH 160
XP_007477992  82 KKHVTVWQVCSSPLERGKLLVSQTCEIGEPFSVLPQGCVWHPKKAILTVLTSHEVSVLPSVHCDSTRVKADlVKVQGFVH 161
Q5ZKI7        81 KKHITVWQLCFNAADRNKLLVSQICDISEPFPVLPQGCVWHPKKEILAVLTTRDASVLHSVHLNNCRIKAD-IKGSGLIH 159 chicken
XP_003215426  82 KKHITMWQLCYSVSERNKLMVYQISEISELFPILPQGCVWHPNKEILAVLTTRDTSVLHSIRVNSSRIKAD-IKGTGLIH 160
XP_008115227  82 KKHVSVWQLSHSATEKNKLMVSQTCEVGEPFQLLPQGCVWHPKRDILSVLTKRDASVLYAVRSDNSRVKAD-IKSSGLIH 160
XP_069055211  82 KKHVSVWQLQLSTLEQNKLLCTQTCEMSEPFPVLSQGCVWHPKKDVLAILTKRDASVLFSVRVDNRRVKAD-IKGSGLIH 160
XP_040015976  82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILVVLTKKDASLLFSVRVDNRRIKAD-IKGSGLIH 160
4_pfamImport  81 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILAVLTKRDTSVLFSVRVDNRRIKAD-IKGSGLIH 159
XP_007229773  82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILAVLTKRDASVLFSVRVDNRRVKAD-IRGSGLIH 160
Q5RFV8        82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKMDVLAILTKRDASVLFSVRVDNRRVKAD-IKGSGLIH 160 zebrafish
XP_002188893 161 CACWTKDGNRLVVAIGSTLHSYIWDNAQKTLNICSFCPVFDVGGYICAIEATLDFQIAVATELPLDNICGFNAGIAFDVP 240
XP_007477992 162 CGCWTHDGQRLVVALGSTLHSFTWDDSQKSLQPCTFCPVFDLGKNICSVLATVDMQVAVATELPLDKICSLNLIEAFEMP 241
Q5ZKI7       160 CACWTKEGNRLVVGVGSALHSYIWDDTQKTLNACTFCPIFDVGGYICAVEATLNFQIAVATELPLDKICGLNAGVAFEVP 239 chicken
XP_003215426 161 CACWTEEGNRLVVGIGSALHSYIWDDDQKTLNACSFCPIFDVGGYICAIEATLNSQVAVATELPLDKICTLNAGISFEMP 240
XP_008115227 161 CACWTKDGNRLVVAISTALHSYIWDNARKTLSACSFCPIFDVGSYICAIEATVDFQIAVATELPLDKICGLNAGITFELP 240
XP_069055211 161 CACWTKDGTRLVVAIGSALHSYIWNDIQKSLNACSFCPIFDVGGYICAIESTEDAQVAVATELPLDKICGLNAGMAFDVS 240
XP_040015976 161 CACWTKDGTRLVVALGSSLHSYIWNDIQKSLVACSFCPVFDVGGYICAMEATGEAQVAVATELPLDKICGLNAGMAFDLA 240
4_pfamImport 160 CACWTKDGTRLVVAIGSALHSYIWNDIQKSLVACSFCPIFDVGGYICAIEATGEAQVAVATELPLDKLCGLNAGIAFDLP 239
XP_007229773 161 CACWTKDGTRFVVAIGSALHSYIWNDIQKSLVACSFCPIFDVGGYICAIESTDEAQVAVTTELPLDKICGLNAGIAFDLP 240
Q5RFV8       161 CACWTKDGTRLVVAIGSALHSYTWNDIQKSLVPCSFCPIFDVGGYICAIESTDEAQVAVATELPLDKICGLNAGMAFDLP 240 zebrafish
XP_002188893 241 SGTEGvslISQAALVLGDEEYSMDTRRKSIDSDRSGVDs-vASSSSGPVDLTHILANHRRSDPSPLITLKRKDSAATNGQ 319
XP_007477992 242 TMEETq-pSTTPSSPVITEETLIDTGKVSPDSEPSSSSaslSSSSLDSLDLTQTLPGNYRSDPSSLFHLREKEYLARAGQ 320
Q5ZKI7       240 ASIETesfPSQSS-LCGEEEYSMDGGKKVLDAEKPMS------AVTSPVDLTHILSSKPGADSSPLLHLRPKDYLTGSGQ 312 chicken
XP_003215426 241 AEVVGnsvPSQTTSLSCEEEHTVDVGKKLPDQEKSGSL---VTSASSPVDLTHLSSNKHRSENSPLINLKPKDYLTGSGQ 317
XP_008115227 241 VGTETgsvTSQSTLVLGDEEYSMDLRRKSIDSDKSATIesvASSSSGPVDLMHILANHRRSDPSPLITLRRKDYPSGTGQ 320
XP_069055211 241 SASETgslPSQSSVLVVDEDCFLDSRRRSIDSERSLALnsiASSTSGPLDLTHILANHRKSDPSPLIHLKRRDHITGSGQ 320
XP_040015976 241 SESESl-hSHGSSTVFSEDDSGVDSRRISFESERSYI------PSSGPLDLTHLLARHRRSDPSPLLHLRRRDTISGSGQ 313
4_pfamImport 240 TETETl-hSHGSH--MSDDDSLLESRRRSFESERSYI------PSSGPLDLTHLLARHRRSDPSPLIHLRRRDTVTGSGQ 310
XP_007229773 241 NESDQs--SQQSPVVMLDQDVSLDSRRRSFDSERSLPLg--FISSSSPIDLTNILAKHRKSDPSPLIHLRRRDNLTGTGQ 316
Q5RFV8       241 NESEGl--CRPSAALTVDTDYYLD-RRRSCDSERSGH------ASSGPIDLTNLLAKHRKSDPSPLIHLRKRDNLTGTGQ 311 zebrafish
XP_002188893 320 DSSHLILVTFERKVTTTRKVTIPGILVPDIMAFDLRAQIVAVASNTSNIVLVYSVTSSSMPHIQQIQLEKNERPKGLCFL 399
XP_007477992 321 ESSHLVLVTLDRMVTTTWKVGIPGILVPDLLAFDPKSQVLAVASNTCPTILVYSLTPTLVPGVQCIRLENCERPKGICFL 400
Q5ZKI7       313 DSSHLILVTFEKKVTSTKKVSIPGILVPDIMAFDIKTQTVSVASNTCNVILVYSLTSSNLPNIQQIQLEKNEKPKGLCFL 392 chicken
XP_003215426 318 DASHLILVTFERKVTATKKVSIPGILVPDIMTFDSKAQTVAVASNTCNLILVYSLTSSHLPNIQQIQLEKSERPKGLCFL 397
XP_008115227 321 DSSHLILVTFEGKVTTTRKVSIPGILVPDIIAFDLKAQTVAIASNTCNIVLVYSVTSFCMPNIQQIQLEKSERPKGLTFL 400
XP_069055211 321 DSSHLILVTYERKVTTTRKVSIPGILVPDVIAFDPRGRTVAVASNTCNMILVYCVTASAMPNIQQIQLQKTERPKGLCFL 400
XP_040015976 314 DSSHLILVTYERKVTTSRKVSIPGILVPDIVAFDPRGSTVAVASNTCNMVLVYCITASAMPNIQQISLQANERPKGVCFL 393
4_pfamImport 311 DSSHLILVTYERKVTTTRKVSIPGILVPDIVAFDPHCSTVAVASNTCNMVLVYCITASTMPNIQQISLQQNERPKGVCFL 390
XP_007229773 317 DSSHLILVKYERKVTTTRKVSIPGILVPDIVAFDPRGSTVAVASNTCNMVLIYSIMASSMPNVQQIHLQKNERPKGVCFI 396
Q5RFV8       312 DSSHLILVTYERKVTTTRKVSIPGILVPDIIAFDPNGHTVAVASNTCNMILVYCITDSSMPNVQQIQLQKNERPKGVCFF 391 zebrafish
XP_002188893 400 TDKLLLILIGKQRFPDPNLIPSSSSDRYVIRLMVKELMLEENS------SAFPETKQKMFYNFES--SVNIPGKRKFFEN 471
XP_007477992 401 SDKMLLILVGKQKFTDPTFLPSSKSDRYTIRLMVKEVNFGDEP------SIKFVWSQQDFYNDSP--ALGLANQRKPGES 472
Q5ZKI7       393 TNKLLLILVGKQKFTDPAFLPSSRSDKYMIRLMIKELIFEVAP------STSASVNGSCASVNGSlnLSNIP------HD 460 chicken
XP_003215426 398 TDKLLLILVGKQKLTDPAFLPSSRSDKYILRLMIKEVVGKEGS------SALSGVTQVC--------FTNVPVKRETIET 463
XP_008115227 401 TDNLLLILIGKQKFTDPALIPSSNSDRYIIRLMIKELSFEEES------SAKSNVPQSLPFSVES--SVNLSGKRKYFDN 472
XP_069055211 401 NEKMLLLLVGKQKSNDPAFLPSSNTDKYIIRLMTKELIYNEES------SSMTAFSQNSSNADSG---VSIPGMKKYFEN 471
XP_040015976 394 NDKTLLLMSDRQKSNEPAFLPSSNTDKYVLRLVAKELMLNGEIpl---tPPPSDHSREPPSNFGL-------RIRRHSEH 463
4_pfamImport 391 NDKILLLMVGRQKSNDPAFLPSANTDKYILHLIAKELIYDGESpmssiiPSPSAQSHESTSNFCT-------GIRRHSEH 463
XP_007229773 397 NSKMMLLMVGRQRSNDPAFLPSSNTDKFVLRLMAKELLFDEDT------TSPVVQKPESPSNFHG--------VRRHSEN 462
Q5RFV8       392 TNKMLLFMIGRQKSNDPAFLPSSNTDKYILRLTAKELVFDEES----------TTKSESPSQHHG--------IRRHSEN 453 zebrafish
XP_002188893 472 LATEDQ--PQSRELLIPRSTVIQSPSGRRRLIEEVKspsyeqSSSSSVSDldekrlpgdSLVALEtldAEPMNRSVSLRG 549
XP_007477992 473 LCLNTC--PQKKDLLMPPR--IQSLPQGKSLIEDITgasgrqSPRPNTTQlskpkltpnVSVSVEgleGIPATFSPNARP 548
Q5ZKI7       461 VSTDVH--PLSRGLLIPDRAALQSPTSRRKLIEEIKspgyeqSCLLNMSDlkekkvslnFPPAVEslnAEPLNQSASLST 538 chicken
XP_003215426 464 HSSDTH--PLKDGLLLPGCNVPQSPKNRRKLIEEIKststdqSLSMNRVDskekklpkdFPQALEaldMEPANRSLVLQG 541
XP_008115227 473 LAAENH--VVGRELLIPGSTIIQSSSGRRRMLEELKspsyeqSSSSSMSDfderraladPTIALEtldTEPVNRSVALFG 550
XP_069055211 472 LSKEERv-QGVKELLLPAGTVIQSPSGRRKLIEEVKsc--eqSPVASVTDfsdratsseSSIAIEnfdNEPINRSAGLTV 548
XP_040015976 464 QPKDDRehQGIKDLVLPGGGVVRSGANRRRLVEEVRsg--elSPVTSSVDfsdralsspSSVAVEtfdMDHVNRMTCLAV 541
4_pfamImport 464 LSKDDRerPGIKDLILPGRGVVCSPGNRRRLVEEVRss--ehSPITSSVDlsdrapssaSSVTVEnfdMDHVSRMASLAV 541
XP_007229773 463 VSKD----LAVRDLVLPGGSVIHSPNSRRKLIEELRss--epSPVPSSVDysdratsstSSITLEnydMDHISRMATLAV 536
Q5RFV8       454 FTKEDR--LSIKDLILPGGSVIVSPSSRRKLIEEVRss--dlSPVASSADfsdr-assaSSVTLEnydMDHITRMASLAV 528 zebrafish
XP_002188893 550 CGSPSRISSRPTSPKVQfnviqe----asnypKNSNLPSERGMSHISRNLERLCGSFNELQLSLSEISDLARNGRR--IS 623
XP_007477992 549 SLPMTQCSPICEPLNLP---------------QGKGARNEEEEGRLCETLERLSGSLLDLQKCLSELIDLLHGKKQplPL 613
Q5ZKI7       539 --TSLAFSNKPTSPKRQietask----ipnsyKNNLLS-EKEASYFSKNVEKLSGNFTQLQHHVCELTELLKAGKR--NL 609 chicken
XP_003215426 542 PESSSGVSNVPISQNKPlhsphe----isnasKTNLLRNDKEASYISKNLERLCSSFAELQHQLFEVTELLKSGKK--TV 615
XP_008115227 551 LGTSARFSHRCVSPKAiqet--------lnspKNNILASEKGACQISRNLERLCGNFNDLQLRLLEITEFSKNGNK--LS 620
XP_069055211 549 TGPTSRESSRPSSPRSEslerih---sapalpKNNSLPKEKTVDQLSQNLERLFARFSEVQQCLSEITDFTRNGKK--SM 623
XP_040015976 542 AGQASRESSRAGSPRHEpsdklhtdptlpfpeKAAGPAKERALEQLGHNMERLFARFADVQQCLAEIRDYNQNGRK--AP 619
4_pfamImport 542 AGQVSRDSSRASSPRFEpsdkihteptlpmpeKTPGKAKERALEQLVHNMERLFTRFAEVQQCLTEIRDYTQNGKK--AP 619
XP_007229773 537 AGQASRESSRPCSPRYEpsekll---sdppmlQNSCSSKEKNLEQLAHNMERIFARFDEVRQCLTEIKDYAQNGRK--PF 611
Q5RFV8       529 AGQASRDSSRPCSPRYEtsekly---sdatppKNS---KEKNLEQLTQNMERIFTRFAEVQQCLSEIREFTQNGKK--IA 600 zebrafish
XP_002188893 624 LAYPCSQEPPVVHVTYQKSFSNGSiTEETKDVLLCDGKIHLSLVQQLFDLPVIEMKHGSSWIVLTADKDGFVPLIFKATQ 703
XP_007477992 614 TRYPLSQDPSFLLITYQKPSSAGP-VLDKRAVLLCDGKVRLQQVQQVFGLSLVEMQYGSLWILLSADGEGFIPLTFSAAQ 692
Q5ZKI7       610 PMYPSSQEPSFINITCQKQLSRND-SDERRSVILCEGKLRLSVVQQIFNLSLVEMQHGSSWIVLTADSEGFVPLTFTSMQ 688 chicken
XP_003215426 616 PRYPSSRDPSFVNIIYQKESSGTV-TPEKRAVILCDGKLRLSVIQQIFNLVLIEMQHGLSWIVLTADQEDFIPLTFDTQQ 694
XP_008115227 621 VAYPSSQEPPFVHITYQKLYSNGSiIEETKTVLLCDGKIHLSLVQQLFDLPVVEMKYGSSWIVLAADNEGFIPLTFKAKQ 700
XP_069055211 624 GAYPSSSDPPFVNISCQKQLSENVfIDERRPVLLCEGKLCLRVIQELFSLSIVEMLHGPLWIVLVADGEGFVPLTFKHRD 703
XP_040015976 620 GVYPAASEPPYVNVTCQKQLSENVfIDERRPVLLCDGKLCLRVLQDLFSLTIVEMMYGPLWVVLVADADGFVPLTFKPKE 699
4_pfamImport 620 SVYPNASEPPYVNVTCQKQLSENVfIDERRPVLLCDGKLCLRALQDLFNLTIVEMMYGPLWVVLVADADGFVPLTFKPKE 699
XP_007229773 612 ISYPAASEPQYIHVTCQKQLSENVyTDERRPVLLYDGRLSLRVVQELFSLTVVEMMHGPMWIILVA----DADGFVPLTF 687
Q5RFV8       601 CSYPSAYEPQYVHITCQKQLSENVyTDERRPLLLCGGRICLRVVQELFGLTVVEMMHGPMWITLVADADGFVPLTFKHKD 680 zebrafish
XP_002188893 704 EIII 707
XP_007477992 693 EVTI 696
Q5ZKI7       689 EVVV 692 chicken
XP_003215426 695 EVVI 698
XP_008115227 701 EIII 704
XP_069055211 704 EITI 707
XP_040015976 700 ELTV 703
4_pfamImport 700 ELTV 703
XP_007229773 688 KHKE 691
Q5RFV8       681 ELTI 684 zebrafish
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