Conserved Protein Domain Family
SARG

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pfam15385: SARG (This model is not part of the current CDD release)
Specifically androgen-regulated gene protein
This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.
Statistics
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PSSM-Id: 521817
Aligned: 19 rows
Threshold Bit Score: 440.044
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005329531 120 SGSSDSSYDFLSAEEKECLLFLEETIGSL-DTEADSTLSTEESEPATTP----------RGFRTLPV-IQPVPQRNSEKT 187
7_pfamImport   1 SGSSDSSYDFLSAEEKECLLFLEETIGAL-DTEADSGLSTDESESATTP----------QGSLTLPI-TQLTPWGNPEGT 68 
A5D7K1        33 SGSSDSSYDFLSAEEKECLLFLEETIGSL-DTEADSGLSTEKSEQATTP----------QVPRALPK-TQPAPQGHPEE- 99  domestic cattle
ELW47758     292 SGSSDNSYDFLSAEEKECLLFLEETIGSL-DTEADSGLSTDESEPATTP----------RSFRALPI-TQLAPE------ 353
5_pfamImport   1 SPQSDSSYDFLSAEEKACLLFLEETIGSL-DTEGDSGLSTDESELVPTP----------RGFRAPPK-TQPAPKGNPKEA 68 
EGW00962       9 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSP----------RSFRALPI-TQQAPQGNPEVT 76 
Q8BI29        33 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSP----------RSFRALPTaTQQAPQGKPEAT 101 house mouse
XP_003474708  33 SGSSDNSYDFLSAEEKECLLFLEETIGSL-DAEADSVLSTDESEPATTP----------RSFRAPPF-TPLAPHGNPEET 100
XP_007481357  33 SGFSDSSYDFLSAEEKECLLFLEETIGSLeDKEADSGLSTDESQPAT-P----------QGPR-----TQPVLQGYQEER 96 
1_pfamImport   1 SGYSDDSLEHLSAEERACLMFLEETIESL-ELEEDSGLSNDEPESLPSHgnvapkfghlSSSKSKPDdVHKPPY---NNS 76 
XP_005329531 188 IIQQAPEPRKVTHSSSFRPPEPHSLSFKSGSYSL---PRNIHIGGNQNLRKSP----TQTNSHFPG-ESEGLIAKPEKKQ 259
7_pfamImport  69 TTHQEPEPRRVTQSHSSRPPEPQGLGLRSGSYSL---PRNIHIGQNQNLRKST----TQANSHIPG-DAEELVAEPE--Q 138
A5D7K1       100 ITGRVPEPKRVTPFSSAHPPGPQSLGLRSGSYSL---PRNIHIGRNQNLRKST----TLTNSHNPG-GSEGLVSGPETEQ 171 domestic cattle
ELW47758     354 ------EPRKVSGSSSFHPSEPQRLGLRSGSYSL---PRSIHIGRSQNLRKST----TQTNGHGPG-ESVGPVAKPEKEQ 419
5_pfamImport  69 IAEQRPEPRTVTQASSFHPPEPQGLGLRSGSYSL---PRNIHIGRNQNLGEST----SQTNSHAPG-EPAGL---PAVKQ 137
EGW00962      77 DIQQVPSPKRVPQSSG--PPESPSLGLRSGSYSL---PRNLHLGRSQNLRESA----TQTNSHGSQ-TPGVYLAEPEKAQ 146
Q8BI29       102 DIQQVPVPKRVAQPSC--PPESHSLGLRAGSYSL---PRNLHLGRSQNLRESA----TQANSPVSE-ASEVFLEEPEKGQ 171 house mouse
XP_003474708 101 VTQQRPEPKRVNETSSSSPPEAQGLGLRSGSYSL---PRNIHIGGNQSLRQST----TQTNSHFPArESEGPLAEPTKAE 173
XP_007481357  97 LTQGRPEQKRDIQSTTTRL--RQDLSVKSGSHSL---PRNIHINRDQSLREGSacrpSQSEGHIPR----GLVLAPLGHR 167
1_pfamImport  77 ITERY--SKDNKPTMNYMVPTPLVL-PKNGSATLssaGRGTE---SSAVSTNSetrlTETTGHSLG-------------- 136
XP_005329531 260 ASQSR--EPS------QAPANPLGA---ALDLDVVLIPPPAAFQDAQPEQ-------------GRKDSLPK---GPGE-- 310
7_pfamImport 139 VNQRS--VPS------QAPASPQGA---APDLDVVLIPPPEAFRDTQPEQ-------------CREDSLPK---GPGQqs 191
A5D7K1       172 VSQSR--EPR------QTLATPPDA---ALELDGALIPPPEAFRDTQPQQ-------------RGQGSLPR---GPGEls 224 domestic cattle
ELW47758     420 VGQSS--EPS------QPPARHREV---ALDLDVAVIPPPEAFRDTQPAQ-------------PGENSLPK---GLGEqk 472
5_pfamImport 138 PGSRLngEPR------PGPAGPREA---APDLDVAPIPPPEAFRDAQPEQ-------------REEDHLPK---RPGEqs 192
EGW00962     147 TSQTT--KPF------QSPAPSQET---TLDLNTVLIPPPEAFQDIRPKQ-------------SREESPLK---ELGEkr 199
Q8BI29       172 TSQGAkaKTI------QPPAPSQKG---TLDLSTVLIPPPEAFQDIRPKE-------------SGEESPPK---KPGEqt 226 house mouse
XP_003474708 174 ASQSS--EPH------KAPASPRRA---SLHLDTELIPPPKAFQDGWLQQ-------------GGEDSLLK---GPGEqs 226
XP_007481357 168 TSRVV------------PPVSPGTP-----ELEEVLLPPPEAFRDTYQEQdtrrsqflkektrSGQDSLPL--------- 221
1_pfamImport 137 -------SPDpdhldkKPKEEDKKPkknKSEISFEVIPPPSDFRDELVTVgnk--------kkLESDQTTKtllRSDQpv 201
XP_005329531 311 PRPQLHPPF---SRLERVEGDSEAMSHPA--SG--KGSTGASGKPQPSPAG--LSWNA-------RAEDASLPPGADPNP 374
7_pfamImport 192 HTLQPHMPV---SSQKREQISSETMSQKA--KE--KESEGNARRPQPQPAM--LSQNA-------RAEDTPLPSGEDPNA 255
A5D7K1       225 PRPQVHPSL---SSQRNREPAPEAMSQKA--SE--KGSTGEPVPPRPPPLV--SSRDA-------GSGDAAVLSGGHPSA 288 domestic cattle
ELW47758     473 HPPP--------NSQQRKETSSETMSHKA--NE--KGITGGPSQPQPPPAT--------------STENAPRPLSGEPSA 526
5_pfamImport 193 QAPHAR---------KTEETSSEAMSHKA--NE--RGSVGHP---------------------------QPLASASDPGA 232
EGW00962     200 YTPQAHSLV---SLQKKE--PSETMSHKA--TE--KGWTEGPQQPQLPPTQ--SSQNT-------RAEEALLPSGVKPNT 261
Q8BI29       227 HTPQVHSLErspHSQKKVEMSSETVSHKA--TE--KGWTEGLQQPQQPPAQ--SSQPT-------KAEELSLPSGVKPSI 293 house mouse
XP_003474708 227 HAPPKR---------------VEVMSLTD--SK--KGTPEGPGQPQPTPTR--LSQDA-------RAEDTSLLLGDDTNG 278
XP_007481357 222 --PRAAP-----VTQEKKEVFLETMSQGT--KEvlEGLPRQPGLPLPL-----SSENL-------GSENLTIPLGDEKSP 280
1_pfamImport 202 ENPDVA------PSRPLSSESLDKLRQKAylKKtpQNTPDLKDKPQSLSGLpvPDEKItvtsvhsDSRPHPTHLHDQAET 275
XP_005329531 375 RMAPLT-APKPRKLPPNIVLKSSRSSFHSDPQNRLSRHHEA--GESGL-----VSSALQDQRKARREALEKLGLPQDP-E 445
7_pfamImport 256 RLGPIT-APKPRKLPPNIVLKSSRRSFHSDPQNWLSRHTEAasGDSSV-----VSSSVQEQRKARREALEKLGLPQDQ-E 328
A5D7K1       289 RPAPLT-APKPRKLPPNIVLKSSRSSFHSDPQNRLSRHSEAapGDPSP-----ASSSLQEQRKARREALEKLGLPQDQ-E 361 domestic cattle
ELW47758     527 QLPPLT-APKPRKLPPNIVLKSSRSSFHSDPQSWLVRHTEAtpGDSGL-----VSSSLQEQRKARREALEKLGLPQDQ-D 599
5_pfamImport 233 QPASLA-APKPRKLPPNIVLKSSRSSFHSQPQNWLSRHTEAasGESGL-----GPSSLQEQRKARREALEKLGLPQDQ-E 305
EGW00962     262 QQAPLT-ASKARRLPPNIVLKSSRSSFHSHPQNWLSNHTEAt--DSGP-----VPSSLQEQKKARREALEKLGLPQDQ-D 332
Q8BI29       294 QQTPLT-ASKARKLPPNIVLKSSRSSFHSHPQNWLSNHTEAt--DSGP-----V-SSLQEQRKARREALEKLGLPQDQ-D 363 house mouse
XP_003474708 279 RLAPLT-APKPRKLPPNIVLKSSRSSFHSEPQSWLSRHAEA--GDASA-----ASSSLQVQRKARREALKKLGLPQDQ-E 349
XP_007481357 281 KFAPPT-APKSRKLPPNIILKTSRSNFPSDPQNRFSHRSQAtsRDSTPdhassASSGLQEQRRARREALEKLGLPQDQsD 359
1_pfamImport 276 KMGPPTvAPKPKKLPSNIVLKQHKASLPSQESNLLTGNEHFtsSSS-------PDKTTLDPQKVRMEALKKLGLLKDN-L 347
XP_005329531 446 EPSLPLSRPTSSIRLKEAQ------GQGSSPAPAPAQPSAPAPIAAITPAaekip-----aqgpSPVKPPASALAQGPYP 514
7_pfamImport 329 EPGLHLSKPRSSIRFKEPRd----qRPSPAPAPAPAQPA----GAGPARGp-------------SPKQPPAPTLAQGSSP 387
A5D7K1       362 EPSPRLSRP--SVRLKETGv----qAVSPAPAQVP--------GRAPAAApt-----------qGPSPGKAPALAQPPSP 416 domestic cattle
ELW47758     600 EPGLHLSKPTTSIRLKD-----------PVQAPPQASAAAP--TGKAPTLtpa--------lgvSPKKTPALTVAQGSSS 658
5_pfamImport 306 APGLHLSKPASSFRLREPRa----qGPAPGAAPGPAQPAAPVQVSAAAGKapapapvpalsrgpVPAKAPTPAPAQGSSP 381
EGW00962     333 DPSLLVNKHTSTLKVKEa------qAQSPSQALATVQQASPALAPEAASA--------------AGKTSPV---KAVTSS 389
Q8BI29       364 DPSLLVNKHTSTLKVREa------qPQTPSQARAPARPASPALVSGTASA--------------AGKVSPKKAVAPMDSL 423 house mouse
XP_003474708 350 EPSLSLSHSASFIRHKKTQ------DQGPATFPAPAQPAALPATGQAPA----------------PAPAPAPAPAPTSSP 407
XP_007481357 360 EPSLQRAKSGSILRSRQSPpqastsAPAPVRAPAPAPAPAPVRAPAPAPApa-----------pVRAPAPAPAPAPVRAP 428
1_pfamImport 348 NDSGSTVNPAQSPKLRRSW------------------------------------------------------------- 366
XP_005329531 515 GKTWIPAQEPSLGKVAATKSTPIPIPKAPKA----NSGLTQPKPDSGLTLQESN-IPGL-------RQMNFKSNTLERSG 582
7_pfamImport 388 SKVLIPAQETSHGNVTSAKSMPISIPKAPRA----NSPLTQ--PDSGLTLQKSS-IPGL-------RQMNFKSNTLERSG 453
A5D7K1       417 GKVLVPAQESTPGTAPAAKSTPIPIPKGPRA----HSPLTQRKPDSGLTLQESG-VPGL-------RQMSFKSNTLERSG 484 domestic cattle
ELW47758     659 GKVLLPTQEPSPGKVAAAKSTPIPIPKAPRV----NSPLSRPQPDTGLTLQEGN-VPGL-------RQMNFKSNTLERSG 726
5_pfamImport 382 SKAWTPAQETPPGKVAAAKSMPIPIPKASRA----NSPLTQPKPDSGLTLQDSS-IPGL-------RQMNFKSNTLERSG 449
EGW00962     390 GKSWIHAQETPPGKVAAAKSMPIPVPKTSKA----NSSLTQPKPDPLLTLQESS-IPGL-------RQINFKSNTLERSG 457
Q8BI29       424 SKGWIPTQETPPGKVAEAKSMPIPIPKTLKE----NSSRTQPKPDPRLTLQESS-IPGL-------RQMNFKSNTLERSG 491 house mouse
XP_003474708 408 GKVCTTAQEAPPGPATAHKSMPIAIPKTSKA----NSPPTKPKPDSGLTLQESS-IRGL-------KQMNFKFNTLERSG 475
XP_007481357 429 APVSQVLASGPSARAQGPPSTPIPIPKPTRVssvdNSPPAQSSPGSRLALKEGS-IPGL-------RQMNFKSNTLERSG 500
1_pfamImport 367 --------ETKSANPPNLSNEPKAQPAMPEI----QEPRSRPQVARGYHQRSGSeLPPVanrpspaRPAEVKSATLERSG 434
XP_005329531 583 VGLSSYLSAE--KDPSPKTSTSLGKGSFLDKISPSVLRNSRPRPASLGTGKDFAGIQVGKLA---DLD-QGQSSKRLS-- 654
7_pfamImport 454 VGLSSYLSAE--KDTSPKTSTSLEKASFLDKVSPSILRNSRPRPASLGTGKDFAGIQVGKLA---DLE-QEQSSKRLS-- 525
A5D7K1       485 IGLSSYLSAE--KASSPQTSTSLEKGSFLDRISPSVLRNSRPRPASLGTGKDFEGIQVGKLA---DLE-QEGGPKRLS-- 556 domestic cattle
ELW47758     727 VGLSSYLSAE--KDPRPKTSTSLGKGSFLDKISPSVLRNSRPRPASLGTGKDFAGIQVGKLA---DLE-QERSSKHLS-- 798
5_pfamImport 450 VGLSSYLSAE--KDPSPQTSTSLGKGSLMDKISPSVLRNSRPRPASLGTGRDFAGIQVGKLA---DLE-QEQSARHLS-- 521
EGW00962     458 VGLSSYLLAAe-EDTKCQTSTSLGKSPTLDKVSPSVLRNSRPRPASLGMAKDFTEIQGGKLV---GLG-QGQHSQQLS-- 530
Q8BI29       492 VGLSSYLSAAekKDPSCQTSTSLGKSPFLDKVSPSAFRNSRPRPASLGMGKDFAGIQGGKLV---GLE-QDQCSQQPS-- 565 house mouse
XP_003474708 476 VGLSSYLSAE--KDPSPKTSTSLGKDSVLEKASPSVLRNSRPRPASLGTGRDFAGIQVGRLA---DLE-QGQNSKHLS-- 547
XP_007481357 501 VGLSSYLLAA--KDNAPQTSTSLGKVPILEKTSPNVLRNTRPRPASLGGGKDFASIQVGKLA---DLE-QERNSQRFS-- 572
1_pfamImport 435 MGLGSYMAS---QHADPSYNTRSFKASNKAPASPNQLRNSRPRPASLGTGKDFIEVQGNRTQtgkSTEpTEHETQRPLpp 511
XP_005329531 655 YQGQS-RDKLPRPPCVSVKISPKGVSDEHRREALKKLGLLKE 695
7_pfamImport 526 YQGQS-RDKLPRPLCVSVKISPKGVPGEHRREALKKLGLLKE 566
A5D7K1       557 FQGQS-RDKLPRPPCVSVRISPKGVSDEHRREALKKLGLLKE 597 domestic cattle
ELW47758     799 YQGQS-RDKLPRPPCVSVKISPKGVPDEHRREALKKLGLLKE 839
5_pfamImport 522 YQGQS-RDKLPRPPCISVKISPKGLQDEHRREALKKLGLLKE 562
EGW00962     531 FKGQS-HDKLPRPACVSVKITPKGIPDGHRREALKKLGLLKE 571
Q8BI29       566 FKGQS-YDKLPRPPCISVKISPKGIPDGHRREALKKLGLLKE 606 house mouse
XP_003474708 548 YQGQS-RDKLPRPLCVSVKISPKGVPDEHRREALRKLGLLKD 588
XP_007481357 573 YPGQS-RDKLPRPACVSVKITPKGIPDEHRREALKKLGLLKE 613
1_pfamImport 512 ITQQHtANKLPRSQGISVQIMPKAKTEGDRKEALRKLGLLKE 553
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