8EZA


Conserved Protein Domain Family
PAXX
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pfam15384: PAXX (This model is not part of the current CDD release)
PAXX, PAralog of XRCC4 and XLF, also called C9orf142
PAXX is a set of eukaryotic proteins that belong to the XRCC4 superfamily of DNA-double-strand break-repair proteins. PAXX interacts directly with DSB-repair protein Ku and is recruited to DNA-damage sites in cells thus functioning with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents.
Links
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Statistics
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PSSM-Id: 521816
Aligned: 9 rows
Threshold Bit Score: 284.735
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8EZA_S         8 LCTLP--PGPEPPRFVCYCEGEESGEGD-RGgFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQA 84  human
XP_003473015  10 LCTLP--PGPGPPRFVCYCEPESSEASGlGV-FHLHVTDGAELWSARLPPDSEAARKARCGLDVDEDLAARFRTACQQQA 86 
Q8K0Y7        10 LCILP--PGSGSPRLVCYCERDSGGDGDrDD-FNLYVTDAAELWSTCFSPDSLARLKARFGLSGAEDIHSRFRAACQQQA 86  house mouse
XP_007475463  10 LCMVPasSGQGLPRYVCYWEGPTEPAET-RA-YNLYVTDALELWNTSFTPESLEKHKAQHGLDGAEDYSVWFRVASDRHT 87 
1_pfamImport   1 HCTVV--PGSDGTKYICYSSRRRG------E-SNIGLTNGSEVWSTEFTPEMLAQHRQRFEMRTAADYILKIRSACEGHL 71 
NP_001124069  12 LCTLL--DKNDQSKYVFFTQKLPAG-----V-INIGFTNGEDVWKTHLSEEILSQLFKKFSLKSTEDYTFKIKCACKTGR 83 
XP_023199308   8 FCTVV--DMKSQTRYVCYSRRKEGGGGG-RR-LCVNVTDAAAVWSADCSEDVLKPQGHRPALKSTEDDILRFRTSCLSGD 83 
2_pfamImport   1 YCTVL--DKTSQSKFLCYTRRKDG------M-LSVCLTDAANVWSVEYTKDSLKHLGQRFALKSTEDYVLKLRAFCNSGD 71 
Q9BUH6         8 LCTLP--PGPEPPRFVCYCEGEESGEGDrGG-FNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQA 84  human

8EZA_S        85 VALTLQED-RASLTLSG-GPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRLaAA-EETAVSPRKSPRPAGPQlF 161 human
XP_003473015  87 IALSLRED-RASLTLSG-PPSTLTFDLSKVPSPEAAPRLQALTLGLAERVCSLEQRL-AAvEEAAISPRKSPRPARPPlF 163
Q8K0Y7        87 VTVSLQED-RALITLSG-DTPALAFDLSKVPSPEAAPRLQALTLSLAEHVCNLERRL-AAaEETITSPKKNTQPAGTQ-F 162 house mouse
XP_007475463  88 VSLTLKDDsSAYLTISR-GAETLTFELSKVPSLEAAPQLQALMLGLAEQACRLEKQL-AAlKDESPSPRKKSQPGGQQlF 165
1_pfamImport  72 ASLLVQDS-GITLELGGpGPGALTLSLTRLQDPEGREEIRGLLFSMAERLREVES------TAQSFSPVKTQQRCSSD-F 143
NP_001124069  84 AFVKLLED-SAVLHLGA-EATDLSLSLAKLTDSEGRMEVKDLLFKMADSLQQLDSQG----ASSSFSPGKGYQKRSAE-F 156
XP_023199308  84 VRVVVQHS-RAALHVGS-GPAALSVTLTRMEAPQATEELKELLFTMADTLAQLDS------GSSAVNPFKSLQRCPAD-L 154
2_pfamImport  72 VSVAVHEV-GAELHLGS-SPEDLSITLSRLEGPQATDKLKELLFTMADSLTQLDSGP-SN-GPPSASPVKNYQRRPTE-F 146
Q9BUH6        85 VALTLQED-RASLTLSG-GPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRL-AAaEETAVSPRKSPRPAGPQlF 161 human

8EZA_S       162 LPDPDPQRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET 204 human
XP_003473015 164 LPDHDPQRGSPGAGVRRRCPGESLINPGFKSKKPASGVDFDEP 206
Q8K0Y7       163 LPELDHQRGSSGPGVRRRCPGESLINPGFKSKKPAAGVDFDET 205 house mouse
XP_007475463 166 LPDPDSRRSAPGPVMRKWMPGESLINPGFKSKKPASGVDFDAV 208
1_pfamImport 144 EPRRRHNGGGASAAVKKRLPGDSLINPGTKRKKEASGVDFDDG 186
NP_001124069 157 EPKKQHK--GPVVAVKKRLPGDSLINPGTKRKKPATGVAFDDE 197
XP_023199308 155 KPRQQQN--GAASVTKRRLPGASLINPGTKKKVQATGVAFDDE 195
2_pfamImport 147 EPWQQQN-SAPAMTMKKRLPGSSLINPGVKKKQQATGVAFDDA 188
Q9BUH6       162 LPDPDPQRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET 204 human
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