Conserved Protein Domain Family
TMEM237

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pfam15383: TMEM237 
Transmembrane protein 237
This protein family is found in eukaryotes. The function of this protein is to aid the production of new cilia in ciliogenesis. Mutations in the protein cause a disease, named Joubert syndrome type 14 (JBTS14) and also affect cell signalling using the Wnt pathway. Proteins in this family are typically between 203 and 512 amino acids in length. There are two completely conserved G residues that may be functionally important.
Statistics
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PSSM-Id: 495057
Aligned: 16 rows
Threshold Bit Score: 234.948
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002111935 177 DFDH-DLNLSPEDV--------ITSK--DYNIEITePPNLVPSLPSQPLNV-----VYVERTdgggfRRVNKSNLN-DMK 239
XP_009022945   9 GLSN-DLEGMEEDVqstnqifsVNDF--AKIISQQ-----SNTVPSQADDK-----IYIEGS-----DRFKAKNrlkvdQ 70 
XP_032512174 250 ARPS-DLTAMLESLean---vpFNDQyiDNPFSSPsPLTSPNDERRDPFGSrrpekIYLQGG-----GTFRAVSRD-RIL 319
F1NVK6       125 HSSN-ELEVEEDDI--------IEDE--HRRSPDQqPVFAAPTGISQPVSK-----VFVEKN-----RRFQAADRA-ELI 182 chicken
NP_001101690  27 QYAS-ELGVEDEDV--------ITDE--QSTLEHH-SRFTAPTGVSQPVGK-----IFVEKS-----RRFQAADRS-ELI 83 
Q66IE4       145 QSNN-ELDVEDDDV--------ITDP--QSPIPQH-SLFSAPQGPSQPVGK-----VFVEKS-----RRFQAADRV-EQW 201 zebrafish
F1Q930       116 QSHN-ELGVEEDDI--------ITDV--HAPISQR-SLFSAPLSHSHPIGK-----VFVEKN-----RRFQATD------ 167 zebrafish
5_pfamImport   1 HHSN-QPQDQDEGM--------MGDG--QAP-----PLFSAP--HSQPGGR-----GSLGRT-----REHFQSERV-DQL 51 
3_pfamImport   1 EHHNsDLVVEDDDI--------TTDA--QSPIPQH-SLFSAPHGHSQPVGK-----VFVERN-----SECERKKKK-QQH 58 
XP_056664473 286 HYTN-ELGVEEEDI--------IADE--QNHPEQQpSVFTAPMGVSQPVGK-----VFVEKS-----RRFQAADRS-ELI 343 gray short-tail...
XP_002111935 240 KDKD-IDaLKSKMSNI----TNSAQLGSSVFNIFMKIAFFCEGLLAGFAL--WQTISISTIE-NQVNGTITVLACYNRLS 311
XP_009022945  71 KRAEeLErSQNENMDIyptiLTSQ--AIQIHKIFKTFSLFVSGLFAGIAL--WQIITSYIMYnNGVDN---FLRNHSTLS 143
XP_032512174 320 ESQQsRE----EEKYLhlgdLTPLDVAITVQKAWRNFSPACHGVLGGISLmhLLLISYS----DSLDAG--HLSFHAVVT 389
F1NVK6       183 KTTEnIN-VLLDVKSS----WTTRDVALSVHRSFRVIGLFTHGFLAGYAV--WNIVVIYILAgNQLTTVSNLLQQYKMLA 255 chicken
NP_001101690  84 KTTEnVD-VSMDMKPS----WTTRDVALSVHRAFRMIGLFSHGFLAGCAV--WNIVVICVLAgDQFSNVSNLLQQYKPLA 156
Q66IE4       202 KPSGpIEqSIMDIRSM----WTTRDVSMRVHSGFRVIGLFSHGFLAGYAV--WNIIVVYVLAgDQMSSLSNLLQQFHTLA 275 zebrafish
F1Q930       168 LSHDhLE-EYMEVRPM----WNTRDVAMRVHSGFRIIGLFSHGFLAGYAV--WNIIVVYVLAgEQMTTLPNLLQQYHSLA 240 zebrafish
5_pfamImport  52 RHSDlIN-DYVEPRQT----WTTREVAMKVHSSFRVLGLFSHGFLAGFAV--WNTVVVYQLAgEQLSSLRNLLQQYQKLA 124
3_pfamImport  59 RHSElMD-DYLDPRQI----WNTRDVALRVHSGFRVVGLFSHGFLAGYAV--WNIIVVYVLAgEQMTTLPNLLQQYHLLA 131
XP_056664473 344 KTTEnVD-MLMDIKPS----WTTRDVALSVHRGFRMIGLFSHGFLAGYAV--WNIIVIYVLAgKQLSDLSNFLQQYKSLA 416 gray short-tail...
XP_002111935 312 QAAQSVYYFLLAIATVSVMDR-FDLESHEYVslITRFIRHPVLALCILIHILSLILSTSIAEIDYRIGLY---NVNQSFy 387
XP_009022945 144 APLQCFYYMLFAVCIVYALDR-YDITHPSPHf-WNKVATFQSGAFCIIIYIIGLIFSLAISNIEYRMTFH---QSNSSI- 217
XP_032512174 390 MPYVASYYFFCVLCLLSVLDR-LDITSIDTT---RGLQPWFQPIVLVILYTSCLLVCTAARMYD-ELMVYqytPLVANI- 463
F1NVK6       256 YPAQSLFYLLLSISTVSAFDR-IDLAKASVA--LRGFLTLDPAALASFLYFTALILSLSQQMTCDRINLYtppSENGSI- 331 chicken
NP_001101690 157 YPFQSLLYLLLALSTVSAFDR-IDFAKTSVA--IRNFLALEPTALASFLYFTALTLSLSQQMTSDRIYLYe-pSVNGSL- 231
Q66IE4       276 YPAQSLLYLLLALSTVSAFDR-VNLAKAPAA--MRSLLRLSPVALASVFYFSALVLSLSQQMTSDRINLYkysSYNTTL- 351 zebrafish
F1Q930       241 YPAQSLLYLLLAISTVSAFDR-VNLAKASMA--LRGFLTLDPAALASFLYFAALILSLSQQMTSDRIHLYp--TANETL- 314 zebrafish
5_pfamImport 125 GPAQSLSYLLLAISSVSAFDRrLNLARASMA--LRGFLRLESAALA---FFCGLVLLWSAEQTGPDLHRGslfSANQTL- 198
3_pfamImport 132 YPAQSLLYLLLAISTVSAFDR-VNLAKASMA--LRGFLTLDPAALASFLYFIALILSLSQQMTSDRINLYp--TANETL- 205
XP_056664473 417 YPAQSLLYLLLAISTISAFDR-IDFAKTSVA--IRGFLALDPTALASFLYFAALILSLSQQMTSDRIHLYtpaTVNGSL- 492 gray short-tail...
XP_002111935 388 WPTVTDQNVrrlttqsqtlFSSWRIINLLRGILAIAGWMLVSFNPITAI 436
XP_009022945 218 -IDPNDSRTtn-------mLYIWQILNLIRGLMAIIGWGIISLKPMTDR 258
XP_032512174 464 -------TGnvttptiptfYHTWTHFSIWRSVLSILGLVYFVISNPQDL 505
F1NVK6       332 WTAGMEEEI----------LQPWIVVNLVVSILVGASWIFLSYRPELDH 370 chicken
NP_001101690 232 WPAEVEEPV----------LMPWVIVNLVVALLVGLAWLFLSYRPGMDL 270
Q66IE4       352 WPPGSESSI----------LYPWITVNLVVSLLVGLAWILMSTSPDIDN 390 zebrafish
F1Q930       315 WPPGLEHQI----------LQPWIVVNLVVALLVGLAWVFVATRPDMDY 353 zebrafish
5_pfamImport 199 WPPSSEQQV----------LRPWMVVNLVVALLVGVAWVVVSTRPNTDY 237
3_pfamImport 206 WPPGSEQQI----------LRPWIVVNLVVAMLVGLSWAVVSTRPDVDY 244
XP_056664473 493 WVAGTEEQI----------LHPWIVVNLVVALLVGLSWLFLSYRPEKDL 531 gray short-tailed opossum
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