Conserved Protein Domain Family
SAXO5-like

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pfam15373: SAXO5-like 
Stabilizer of axonemal microtubules 5
This family (previously DUF4601) represents the homologues of Stabilizer of axonemal microtubules 5 (SAXO5, also known as C19orf45, TEX45). SAXO5 is a filamentous SAXO protein that binds along protofilament A04 with 96-nm periodicity. A typical feature of SAXO proteins is the presence of Mn motif which forms a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop. SAXO5 contains 11 Mn motifs and therefore has 96-nm periodicity, matching the external periodicity of the axoneme.
Statistics
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PSSM-Id: 495048
Aligned: 8 rows
Threshold Bit Score: 631.089
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_028907454  62 IFHQDPKIV-TEMITETFRSYPrwPP----------QKRRKGKAMNQQETN-FQMHVDSKI-THFTTSTTMQNSYRVPRR 128
3_pfamImport   1 LFQRDRRWKaEESVSEARRAFT--PP----------AELEDPRARAMPRSScLSLYAGRGAgPVLSSARAAYGWPEVLAH 68 
1_pfamImport   1 FFRQDTRAAgAELQSEAHRAFA--PPapq----psaPSGTRERTLATPATN-LRVYAPARSrTGLSTARADFGWPELPAR 73 
2_pfamImport   1 LFQQDPRWAgEERVSEAHCVFT--PPppsersgereLERARDRTLAMQASH-LVLHADARArTGLSTARADFRWPELPAR 77 
XP_016790352  66 LFPMDPRWDrEERVSEAHRAF---PPpstpp-wellQAQARERTLAMQASN-LHLHEDAHAgIGLSNAHAAYGWPELPAR 140
4_pfamImport   1 LFHVDARWAgEEHVSEARRAF---PPppeqa-weqeRELVRERTRAMQASS-VLMHADARAgSRLSNARAAYGWPELPAR 75 
NP_083874     58 IFQREARWAsQKHVSEMRRAFS--PPptlqs-qdelRERAIEHSQAMQISN-LHLHADMRPgLNLSIARTDYGWPELPPS 133
5_pfamImport   1 ---HDARRAgPEQVSEMHREFT--PRev------qpPEETRERTLAMQSSS-LRMHAGERTgVSFSNARAAYGWPEQPAH 68 
XP_028907454 129 QYSGVKKDIDLFGKDGIPNGDRDKIEMPLTQHRLFYQPHVL-DPVARAPSKHLGGVSPIQENYCQS-SETIYQKDFRGGW 206
3_pfamImport  69 AGERVGGARLIFDQDSVPPGDRDKLRIPPTTYRTLFPPHDA-CPQPRAHSRHLGGPNTLRWDYRRR-EEPSYKTQFQALP 146
1_pfamImport  74 AREQIRGARLIFDRDSVPPGDRAKLRIPPTTYRALFPPHDA-CPRSRAPCSHFGGSNALQWDHRRQdDGTSYQRQFQALP 152
2_pfamImport  78 AREQIRGARLIFDRDSMPPGDRAKLRIPPTTYQELFPPHDA-RPQPCAPRRHLGGPNPLKWDHGRQnDGTSYQRQFQALP 156
XP_016790352 141 TRERIRGARLIFDRDSLPPGDRDKLRIPPTTHQALFPPHDA-RPQPRAPSCHLGGPNTLKWDYTRQ-DGTSYQRQFQALP 218
4_pfamImport  76 ARETIRGARLIFDRDSVPSGDRDQLRIPATTHQALFPPHDA-CPQARAPCSHLGGPNILTWDYRGQ-DGTSYQRQFQALP 153
NP_083874    134 ARLDIRSARLLFDRDSMPSGDRKQLRMPLTSYQAHYPPYDAiTPQPCVPCSHLGGPNTLKWNYKGQ-KDTSYKKQFQALP 212
5_pfamImport  69 ARELIRGARLIFDRDSLPQGDRDQLRVPPTTHQELYPPHDA-CLPPRAPCHHLGGPNTLKWGYKKQ-QGTSYRREFQALP 146
XP_028907454 207 VPPAMLHRESPSSLVFGDPSDNYRFKMSEQKTAFKVQALAHDRYNKKQAAAQTLHVNLQPGDSCLQFHTTTARDFNIPRK 286
3_pfamImport 147 GPPALMCKRAASSIHLGDCTIGYDPGCSELKRAHRPPGLPPDRYDKAQAAAHIHIVSIPPGDGLFHDRTTMSHHFYPRDP 226
1_pfamImport 153 GPPASMCKRASSSVELGDSKIGYGPVCSEQKQAYGPQGLPPDRYDKAQASAHIHYVNIRPGDGLFRDRTTEAEHFYPREP 232
2_pfamImport 157 GPPALMCKRAASSVELGNFKSASGPVCSEQKQAYGPQGLPSHRYDKAQASAHIHYVNIRPGDGLFHDRTTQAEHYYAREP 236
XP_016790352 219 GPPALRCKRASSRVELGDCKISYGSTCSEQKQAYRPQGLPEDRYDKAQAAAHIHCVNIRPGDGLFRDRTTKAEHFYAREP 298
4_pfamImport 154 GPPALMCKRASSSVELGDCKIGYRPMCSEQKQAYRPQGLSPDRYEKAQAAAHIHYVNISPGDGLFHDRTTKSEHFYPQEP 233
NP_083874    213 SPPALMCKRASSSVNLGDSKVGYSPLCSLVKQTYTPQGLSPYRYDKVQAAAHIHQVNVGPGDRLFHDRTTMNDYFYSKEP 292
5_pfamImport 147 GSPALMCRRASSSVQLGDCKLGYGLMSSDLKQTHRPQGLPPDRYDKAQAATHIHQVNIRPGDGLFHGRTTVTDHFYAREP 226
XP_028907454 287 LAAIDTKDK-PHPVFSKRAKESY-SREFITTHNRIYAPVDCQNYAPRESLTWKQTQSHVILGDMELKPYCFTTMHKTDFV 364
3_pfamImport 227 EPFLLHHDQtPESHILKGNWCPG-PGSLTTSMQDFYGQPLPETQPPSHCGADENLQSHMTLAEPKLLGRFFQTTMRSAYC 305
1_pfamImport 233 ERFVLHHDQtPASHILEGNRCPG-PGSLTTSVHFFHGQPLPVNKPPSCHVPHEKLQSHVGLGESSLLGQFFQTSTGTDYC 311
2_pfamImport 237 EPFILHHNQtPESHILEGNWCPG-PGSLTTSMHFFYGQPPPATKPPCRHPPHEKLQSHVTLGEPSLLGRFFQTSMGRDYY 315
XP_016790352 299 EPFVLHHDQtPESHILKGNWCPG-PGSLDTFMQHFYGQPPPPTQPPSRHVPHEKLQSHVTLGEPKLLKRFFKTTMGSDYC 377
4_pfamImport 234 EPFVLHHDQtPESHILKGNLSPGiPGTRELPRCHVVLQPPPPTQPPSRHAAHKKLQSHVTLGDPKLLGRFFQTTMGSDYC 313
NP_083874    293 EPFVLHHDKtPESNILKGNWCPG-PGSLHTSSKFFYGEPPPATQPPGRQVSHEKLKDHIILGDSKLLGNFFQTSMSSDYC 371
5_pfamImport 227 EPFVLHGDQtPKSHILKGNWHPG-PGSLSTSMQFFHGQVPPSTQPPGRHMTHENLKSHVILGEEKLLGHFFQTTTGSHYC 305
XP_028907454 365 PPKaYPEKVdyrlcKatNIKFTWD------DDKGYLSMSRQAMLPHDL-RNSRREEIQQRTSYSSVILPWQDQQFFSTEY 437
3_pfamImport 306 APE-RRQPQ-----K--SLCSQTPflppksAELEFLTTNQTMLKPHRIvGARMTEELLQRCKYSHVEFPLGRQRFFCTEY 377
1_pfamImport 312 SPG--SRPQ-----RapTLHLLRSnlpqgtGETDFLTMNQKMLKPHRTaPASVTEEMLQRCKYNHIEPPLGGQRFFSTQY 384
2_pfamImport 316 PPG-MQHPQ-----KapNLHLKQSnlpqgtGELDFLTMNQKMLKPHRTaPASPTEEMFQRCKYSHMEPPLGRQRFFSTQH 389
XP_016790352 378 PSE-WRQVQ-----KapNLHLQQSnlprgtGEFDFLTMNQKMLKPHRTpPAPVTEEMLQRCKYSHMEPPLGGLRFFSTQY 451
4_pfamImport 314 PSE-MVEMP-----KasSLHLLQSklllgtSEFDFLTTNQKMMKPHGKaRAPRTEEMLQRCKYSHMEPPLGRLCFFSTQY 387
NP_083874    372 PPT-TPIKQ-----RtlKFSLLESnlpegtGELDFFTTNQMMMKPHGIvRASITEDLLQKCKYSHIEPPLGRQRFFSTQN 445
5_pfamImport 306 PQH-VEGSQ-----KipSPQMTQSnlpkgtCEFDFLTMNQKMLKPHGRaKALVTEELLQKCKYSHLEPPLGGQRFLSTNY 379
XP_028907454 438 KDLFPYKYLGPMVPIKGKIQMSRVPLGTFQSHRF-NEK--------GRSPARAA 482
3_pfamImport 378 KDEFPCKYQGPVVLRISNAQESSVPLGTPCQQSCpRRVvdpqapqlPMYPCPSQ 431
1_pfamImport 385 EDEFAFKFQGPAVLRSANLQDSHVPLGSPRQWVCgAGKvdpqtpqpPTYPCPSQ 438
2_pfamImport 390 GDEFTFKYQGPAVLRWGNFQESHVPLGSPRQWGCwGEKvdpqapqiPMYPCPSQ 443
XP_016790352 452 KDEFPFKYQGPAALRLKNPQEGFVPLGTPHQRGC-REKidplvpqpPMYPCPSQ 504
4_pfamImport 388 KDEFLHKYQGPAVLKLSKLQESSVPLGTLRQWGC-GEKtdpqapqlSVYPCPSQ 440
NP_083874    446 QDEYPFKYQGPLVQKLSSMHESHLPMGTPKYLGCwHEKadprgpqiPMYPCLSQ 499
5_pfamImport 380 QVDFPFKYQGPVVLKMMNFQESHVPLGTPRQPGCrHRKvdpqapqmPMYPCPSQ 433
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