Conserved Protein Domain Family
NOPCHAP1

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pfam15370: NOPCHAP1 
NOP protein chaperone 1
This entry includes NOPCHAP1 from animals and New4 from fission yeast. NOPCHAP1 is a client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. The function of New4 is not clear.
Statistics
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PSSM-Id: 405951
Aligned: 29 rows
Threshold Bit Score: 72.3673
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEY53762      46 LLSKLEAFLPVMAEENKKLSDAVAAGEGAKHNIeveeaeDRSDDDsdepmtggsEEDtkpkkggkapVIEMNFALSMMDE 125
CAZ83789      47 LMSRLDAFLPAMEAANKDLQAEVEDGTIGKRNI------EVLDVE---------EER----------YIEMNLGLGVLEG 101
EEN62681      42 VLSSVKRFLPQLSAANQQLQMAAP----GQLDI------QNLEDC---------DGP----------VIEMDLALi---- 88 
EKC38908      55 ILSQVKSFLPQMKMANQELQNRPA----EEIDI------EHVSDD---------QDR----------FIEMNIA--VVEQ 103
1_pfamImport   1 LFSRLEAFMPVMAEENKKLSEAVAAGEGAKHNIeveeaeEESGTDsddamagddEKKgk------apVIEMNFALGMMDE 74 
ERN18772      60 vLGKVKDFLGVMAEANKKLELSVQETR-ADPDI------EVLTGK---------EQQ----------YIEMDLVLGVADL 113
EME86030     122 LQARLDDFMPRLRQANNDLAAKG-----SSLSM------EDVTEG---------EQ-----------HIEMNLGLGVLEQ 170
XP_007674291  42 LQARLAALLPELAAANRQLEQGG-----KDYDM------EDVQDG---------EQ-----------HIEMNLGLGVLEE 90 
XP_009153207 140 LRSRLQEFLPQLQKANVELESSSDI---LDKRI------DHVDDG---------AEQ----------YIEMNLGLGVLSE 191
EKG16997     130 lsdRLKAFLPQLAAANEELERDRATGKLAQMSL------ENVGDD---------EER----------YIEMNLGLGVLKE 184
EEY53762     126 -----------------------------GNSDDENAETA---VDPEAQTkvvdssl---sakkeqQEQLSFRMRLEKPS 170
CAZ83789     102 krd-----------------------gsvSEPGGSGSGES---EGEEGDE----------------EDHDVLLRLLNSSK 139
EEN62681      89 ----------------------------pTCEDSSSSSDS---SSEEEDEdeedaggvdgadqsedRDSGLMGEVTEHSL 137
EKC38908     104 ssd------------------------fsEDNDSEHSSDS---DSDNSD-----------------ADECLMGKVTENNL 139
1_pfamImport  75 ---------------------------------NDSNADA---VDPEAQIktaataningtgseqqEEDASFRMRLEKPS 118
ERN18772     114 ytpeavaaaesalsgtapafsvhsatassSGSGTSSSSDG---DDSDSDEssgs--------pdkcEEPTLSGDLLKRQD 182
EME86030     171 tgdesnk---------------sgdvavrAEAKSPSSSDD---ADEASD-----------------DEANIMSRLMSAPA 215
XP_007674291  91 khg------------------------deTSAEEESSEDE---SEVDEDTaptsllh---eyrpqdKDTRVMQKLTGQHK 140
XP_009153207 192 qrpge-------------------ddevkLEPTTDTSSDQ---GTDEDDEaeqr---------mesSAEDVLARLRGEKA 240
EKG16997     185 rdp--------------------------nrMDSDSESDDepaDAMDTDAdgqq--------dkktKEEDILGKLMGRKK 230
EEY53762     171 NKP------RPVIQ 178
CAZ83789     140 RHGkgp-rgKPSIE 152
EEN62681     138 RLAkdsrrkKPKIE 151
EKC38908     140 RINkrt-khKPDIV 152
1_pfamImport 119 NKP------RPVIQ 126
ERN18772     183 KRKk-----RPKIT 191
EME86030     216 TNG------KISIQ 223
XP_007674291 141 TMQr-----KVAIE 149
XP_009153207 241 QKAs-----KRKVE 249
EKG16997     231 AKA------GPGIQ 238
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