Conserved Protein Domain Family
BTBD8_C
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pfam15363: BTBD8_C (This model is not part of the current CDD release)
BTB/POZ domain-containing protein 8, C-terminal
This domain is found at the C terminus of BTB/POZ domain-containing protein 8 (BTBD8, also known as AP2-interacting clathrin-endocytosis protein). BTBD8 is involved in clathrin-mediated endocytosis at the synapse and plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.
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Statistics
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PSSM-Id: 521806
Aligned: 7 rows
Threshold Bit Score: 58.0337
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001507357 1417 DTFSSRRELMSPPDDPSTSLP-VTNFSSED-SySPQGEWTILELETQH 1462
D4A0X3       1705 DTWNRWSELSSPLDDLTASAT-TVSVSSTD-C-SPQGEWTILELETQH 1749 Norway rat
EGW07960     1128 DSWNRWSELSSPLDGSWTSDT--TAGVPSE-GcSPLGEWTILELETQH 1172
4_pfamImport    1 ES-SRWPELLSPLDPPGASITaVTSYSPEDhGcS-QGDWTVVELETHH 46  
XP_006013649 1765 DTISKWTELMSPLEDSTNSIT-VASFSPED-TtSTEGEWTIVELETHH 1810 coelacanth
XP_046754185 1673 DTFSRWTELMSPLDDSSASIT-VASFSSED-CsSPQGEWTILELETHH 1718 chicken
NP_056052    1236 DTLNRWSELTSPLD-SSASIT-MASFSSED-C-SPQGEWTILELETQH 1279 human
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