Conserved Protein Domain Family
RIC3

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pfam15361: RIC3 (This model is not part of the current CDD release)
Resistance to inhibitors of cholinesterase homologue 3
RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.
Statistics
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PSSM-Id: 521804
Aligned: 22 rows
Threshold Bit Score: 88.2159
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001379100  15 IVLCVSLLLPKAFLSrgrrp------------------epppApsgKMGRFPPMMH------------------HQMPSD 58 
XP_020303424  35 IIMCFAMLYPSMLHP---------------------------Li--SSFFRTPPARktvtnrp------pihpamsSPRS 79 
Q22472        49 IVVCFAMLYPTLFHPm--------------------------Lm-gFLGRSPPSSPsinqqrppihpamgggsgQRHPGG 101 Caenorhabditis ...
EGT59846      46 IVVCFAMLYPTLFHPm--------------------------Lm-gFLGRSSQPSPsinqqrppihpamgggggQRHPGG 98 
XP_006011409  15 VLLVVVVVVPRILGGgggsgarnsghfq-pnhrmkaglrqnpHl--NPDSGGPNEK--------------------AHQN 71 
XP_006633655  15 AVMCGCLVFPRMFGGgtgskdprafephfsrkvgpgplrghqV---NMDTGSGKGQ--------------------SFEN 71 
2_pfamImport   1 AVLFTFVAVPRMFGVgtgaketrvdpr---ytkkagavrgqpV----KPNAPGSSQ--------------------TAEN 53 
XP_005475672  15 GVLFMFVVLPRLYGFgsgta-----------------akdakLdsrYSRKAGPARGq-----------------PINMNG 60 
XP_008109170  18 LVLCAFVVMPRMFGGagranrgakaspgrhephqhrygrperLl--QSQMKSENSD------------------TKMYQS 77 
XP_011611455  15 AVLLMFVVLPRLFGVgtvgentfdprys-rkgpgpgsmrgqpV----SMNAPGASQ--------------------SAEN 69  torafugu
XP_001379100  59 g--PASGTHFPRSHLAEAMAKTKgsggsvgggGGRGLMGQIIPIYGFGILLYILYILFKLSSKGKTT------------- 123
XP_020303424  80 ---RPDLHPGMRMAASQPEMTTPp-------sSSKGMFAWMLPIYTVGVVAFLIYTLVKSKKKRRIKrhdyss---tese 146
Q22472       102 ---GADVHPAMRMAQAQAESQSG---------GSKGMFTWMLPVYTIGVVLFLLYTLFKSKGKKSKRkkrnyf---dsed 166 Caenorhabditis ...
EGT59846      99 hpsRPDVHPAMRMAQAQAAGESG---------GSKGMFTWMLPIYTIGVVLFLLYTLFKSKGKKSKRkrrnnyfdseede 169
XP_006011409  72 mqqQQQQQQAARSAMREDIKSGKvk------gESKGFAFAIMPLYAIGVAVFAAFKFLKMKSKEEES------------- 132
XP_006633655  72 iq-------qMRKMMEQEIKSERlk------aNNKGYVFTLMPLYAIGVGVFAVYKFLKIKSSE-SQ------------- 124
2_pfamImport  54 mq-------qMKKLMEQDLKGDKyk-----pnSSKGYVFTLMPLYAVGVGVFAAYKFLKMKSAG-DK------------- 107
XP_005475672  61 agqSPENLQQMKKRVEQELKSDKyk-----ssSNKGYVFTLMPLYAIGVGVFAAYKFLKIRSTDDKA------------- 122
XP_008109170  78 iq-------qMRNAMEKELKTERsr------gNGKDFALTLMPLYALGVGVFAVYKFLKMKAQEEKL------------- 131
XP_011611455  70 lq-------qMKKLMEQELKNDKyk-----anSNKGYVFTLMPLYAIGVGVFAAYKFLKIKTAD-DQ------------- 123 torafugu
XP_001379100 124 -VEDRKSTTAIHGNPNRKIT-NYELAQLQEKLRETEEVMEKLIN 165
XP_020303424 147 sDEDYNRNDGRTGGIGKR-----KLKGLQERLRQTEMAMEKILE 185
Q22472       167 dDDESESETKYGGKFGKK-----KLEGLQKRLRETESAMSKILE 205 Caenorhabditis elegans
EGT59846     170 dDDESEAETKYGGKFGKK-----KLRGLQERLRQTEDAMSKILE 208
XP_006011409 133 -----SDNEKSKKGKKKTQEtENQLSELEQRLAQTEKMLNSLLT 171
XP_006633655 125 -----TGKEKTSKGAKKSEEtENQLNELEQRLAQTEKMLNSILT 163
2_pfamImport 108 -----AQKEKLTKGAKKSVEaENQLNELEQRLAQTERMLNSILT 146
XP_005475672 123 ------QKDKFAKGAKKSMEaENQLNELEQRLAQTERMLNSILT 160
XP_008109170 132 -----TKNEKNTE--DKTKEtEQQLLELEQHLAQTEKMLNSLLT 168
XP_011611455 124 -----VQKTSFVKGAKKSVEaENQLNELEQRLAQTEKMLNSILT 162 torafugu
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