Conserved Protein Domain Family
TSKS
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pfam15358: TSKS (This model is not part of the current CDD release)
Testis-specific serine kinase substrate
TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ. Recently it has been shown in human testis to be localised to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function. TSKS is localised during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis.
Links
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Statistics
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PSSM-Id: 521801
Aligned: 3 rows
Threshold Bit Score: 446.431
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002917876  66 PMHwclnlkrssactnvSLLNLaameptdtsgtdsttedsgplvlpvppasptppwasddpditeilsGVNSGlvrakds 145
XP_008111811 263 ISK--------------QLLDL----------------------------------------------VSNAT------- 275
XP_007492710 256 leaglsrhslvsscptpPP-EEtirppsepdpqadpptepqp------epqpepelepepapvssptpTPHTGsptel-- 326 gray short-tail...

XP_002917876 146 itslkekttrvnqhvqtlqsecsvlsenlerrrqeaeelegycsqlkencrkvtrsvedaeiktnvlkqnsalleeklrY 225
XP_008111811 276 -------------------------------------------------------------------------------A 276
XP_007492710 327 ---------------------------------------------------------------------------sgprL 331 gray short-tail...

XP_002917876 226 LqrqlqdetprrqeaelqeleqkldaglsrhGLGPTAQSPGCCGPPGSP---NEPPRPRSMAPGGW--GMGPRAGEGPIV 300
XP_008111811 277 I------------------------------ALRPSNSEEGELPPPTAAilaSINNLRVALENGHMraGLGDEVSIDGKS 326
XP_007492710 332 L-------------------------------VNPGDGPEGQGQSEGLGl-aQVQSQSRTGESGEL-------------- 365 gray short-tail...

XP_002917876 301 SEQEMQKVSAGLEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAargLQELRGRADELCT 380
XP_008111811 327 NTASTLACIPLLEEIRKCVLELSGQSQREALTQKEVLRLLAQLGVRLEGLIPQWERTQVEHSQA---LRMLREELDEVSA 403
XP_007492710 366 ---ELQKVTAGLEELRREVSSLTARWYQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQTargLQELRGRADELCT 442 gray short-tail...

XP_002917876 381 MVERSAVSVASLRSDLEGLGPVKPILEELGRQFQSSRrgsdlsmNLDRPPQG--SCGRCASQGpQLSTESLQQLLERALT 458
XP_008111811 404 TVKRTSVSLTQLRADLDGVRQVKPLLEEVSRHLSVLK-------PLETPERQtvSCARCSSYS-FVNTESLRQMVEQAVA 475
XP_007492710 443 MVERSAVSVASLRGELEGLGPVKPVLEELGRQLSSARrgselsmSLDRP--G--SCTRCGSQGqQLSSETLQQLLERALT 518 gray short-tail...

XP_002917876 459 PLVDEVKQRGLAPA-CPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKVATVDYLHL 537
XP_008111811 476 PILEELKQRTPPPGtCPSCQLLQKKIMDLEQSALDIHARAEVLSSNVRLAHDEALRANYLEQARIGTDKDKSSSLDYLQN 555
XP_007492710 519 PLVDEVKQRGLAPA-CPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKVAALDYLHL 597 gray short-tail...

XP_002917876 538 KMCSLHDQLSNLPLEGSTGTMGGGSGGGAPPKRGGPTPEQ 577
XP_008111811 556 KQSSLNSQLVLVSQEGMPQSPAVSLAANVALTKRSSCPGE 595
XP_007492710 598 KMCSLHDQLSSLPLEGSATGLGGGSSGGAPPKRGGPAPEQ 637 gray short-tailed opossum
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