Conserved Protein Domain Family
HECA_N

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pfam15353: HECA_N 
Headcase N-terminal
HECA was characterised first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. It is involved in dendrite pruning and is a branching inhibitor during tracheal development. It also promotes cell survival and niche maintenance in the Drosophila testis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumour-suppressor in head and neck cancers. It may be considered as an interesting therapeutic agent against Wnt-dependent tumor progression. This entry represents a domain found towards the N-terminal.
Statistics
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PSSM-Id: 495032
Aligned: 8 rows
Threshold Bit Score: 158.809
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002426914  52 KCACPT-ECLKENNTsvsgldtdpnIRLD-D---LHDVVRVICNNEQCTVGKYMHRECFESWEQAVLTYLKSCGRAKS-- 124
XP_001999087  66 RCCYPNgECTKLDTL----------IALD-DqsrLGDYVRVVCNNENCNEGQYMHRDCFEQWEAGVLQQLKASARGRS-- 132
1_pfamImport   1 DCCVPTgDCIMRSAP----------IRPE-DpraAELYARVVCSDGGCPAGRYMHRECFDAWERLVLVYMKNAAASYAng 69 
XP_015792965  56 KCCVPTnCNLNQP------------IRME-D---LNDCVKVICNNENCNQGRYMHKSCFEDFQATVLTYLRSTGRARS-- 117
EEC06656      37 ACCVPTgCHLEQV------------IHMD-D---LNNTVKVICNNEQCSQGQYMHRLCFDEWESSVLTFLRSTGRARS-- 98 
EFX73234       9 ECCTPAgCMTIVDGItstdg------ssseD---GGEIVKVLCNNEHCPTSGLMHRQCFDQWEASVLHYLRSCGRARS-- 77 
2_pfamImport   1 -CCFPGvCPFGEDSAa--------------D---ESVMVKVICNSEACPLSQFMHAECFHQWEETILGHLRSHGRARS-- 60 
XP_003384064  67 MCCNPRgCILGP-------------IETGsAtptQQEVVRMMCSNEKCPFSPYMHSECFDSFEEQILSCLRGMSRARN-- 131
XP_002426914 125 ---WSERQRHQNLWT------------KKGYDLAFKACGCKCGRGHLKKDLDW 162
XP_001999087 133 ---WSERQRVQQLWT------------KKGYDLVYKNCSCKCGRGHLRKDLEW 170
1_pfamImport  70 napQSNSRRIKDLWTvnvnnnnvvnlnKKGYEMAFKACGCRCGRGYLKKDSEW 122
XP_015792965 118 ---WSEKQRLQNLWT------------KKGYDLAYKACGCKCGKGHLRKDLDW 155
EEC06656      99 ---WSEKQRMQNLWT------------KKGYDLAYKACGCRCGKGHLRKDLDW 136
EFX73234      78 ---WSERQRSQNLWT------------KKGYDLAFKACGCLCGRGHLRKDCEW 115
2_pfamImport  61 ---WSEKQRRQNLWT------------KRGYDLAYRACACACRHGHLRKDLNW 98 
XP_003384064 132 ---WSEKQRKQNLWT------------KKGYDLVFKFCACQCGKGNLRKDLNH 169
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