Conserved Protein Domain Family
JCAD
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pfam15351: JCAD (This model is not part of the current CDD release)
Junctional protein associated with coronary artery disease
JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 495030
Aligned: 15 rows
Threshold Bit Score: 1773.54
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002919699    1 MYSVEDLLISHGYKVSRSipaPTEDEREGRRQARSRARAGQGLLNGCDDGPAALPPSKPSQG-KGPASTSEN------SH 73  
1_pfamImport    1 MYSVEDLLISHGYKPSRE---PCEDNPEGRQRARTRTRGARGLMNGYEDGPVAFKHSKSSPG-TGHVSDSES------RR 70  
XP_014443080    6 MYSVEDLLISHGYKLSRDhpaAREDDREGRQPARTRTRAGHRLLNGYEDGPAALAHSRPSLG-KGHVSDSES------RR 78  
Q9P266          1 MYSVEDLLISHGYKLSRDppaSREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAG-KGHVSDSES------RR 73   human
XP_003786908    1 MYSVEDLLISHGYKPSRDlsaPREDDPEGRQAARTRARAGHGLVNGHEDGSAASAHRKTPAG-RGHVSDPESr-----RR 74  
A2VE02          1 MYSVEDLLISHGYKLSRKlpaPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPG-TGLLSDPES------RR 73   domestic cattle
XP_008110581    1 MFSVEDLLISHGYKLSKNstnLYENRSDGFQHEVTDRRVSHGPLNGFPTNSAAFANSKKKTGtKSALNDNESshvfrgRQ 80  
2_pfamImport    1 MYSVEDLLISHGYAPSRElpaPRPESPEGRPQARTRTRTGHGLLNGCEDGPAAPARRKTPPG-KGHVNDPDR------RR 73  
3_pfamImport    1 MYSVEDLLISHGYKPARDlpgQRGAKADGHPQAKTRPRGSQGLQNGCEDGIAALAPSRQAPG-PGPVSAPEG------HQ 73  
XP_003468764    1 MYSVEDLLISHGYRPSRDlpgPRGTKADGHAQARTRPRGSQGLQNGCEDGATTLAPSRPALA-TSPVSTPEG------HR 73  

XP_002919699   74 HAPRARGE-PQSALAPRASELGFYHQPVLRWSSQPQTAHDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHTRE 152 
1_pfamImport   71 GTPRGHGE-RPSTSASRAAEAGFYNRPTLAWSSQPQIGNNQAYWRRGGQKVSSLLSPRDRQDLEVRGMAQAHSMPIHVRE 149 
XP_014443080   79 STPRGHGE-PHSTSASRASAAGFYNQPALAWPSQPPPCDDRAYWRRGGQGVRSLLGPREREDREAGGMAQAHSLSVHTRE 157 
Q9P266         74 STPRGHGE-PQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQ-KPREHENLEARGMAQAHSLPVHVRE 151  human
XP_003786908   75 STPRGPRE-PQGASASRTSEAGFYNQPTLVWYPQPQAGSDQAHRKRGGPEVSRSLGPRDREDLEVRGMAQAYSLPGHVRE 153 
A2VE02         74 LGPRGHGErPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEA--------REDPGGRG--PVPSLPTHPRE 143  domestic cattle
XP_008110581   81 PVSVYHQD-VPASTNIYAPEARFYDQSQLNWSSCPKTEKDLAYWRRRGQDFSALLGNTGKEDSETKGMAVPCALYGHDKK 159 
2_pfamImport   74 REPPS------------AAEAGFSNRPALVWSAQPPPRDDPGHWRR-GPEGSGLLGSRERKELGIRAMAQAHSLPAPMQE 140 
3_pfamImport   74 GVPRHHVE-HHRTSASRAPEAGFYKQPALAWSSQAQIGNDQVCRRR-GQKASSSLGPRDRDEPEGRGVAQARSLPVHMRE 151 
XP_003468764   74 GAPRHHVE-PHRTSASGAAEAGFYNQAASVRSSQSQIGTDQACWRR-GQKATSLLGPQDPDDLEVRGVAQACGLPAHMRE 151 

XP_002919699  153 GPWEVGGRTENVMKKAVWEEELRMAGPAKWQNISLESWNQPRKLGRQMSDGDGEKMFQDLYPFMQGEQALNSQSKGKSQS 232 
1_pfamImport  150 GSWEVGGRTEDVMKKAVWEEELRMSGSAKWQNVSLESWNQPRKLGKQMSDGDGEKLFQELYPFIQGEHVLTSQNKKKSRS 229 
XP_014443080  158 GPWEVGRRTEDVMKKAIWEEELRTSGAAKWQNVSLDSWNQPRKIGRQMSDGDGEKLFQDLYPFIEGQRVLNPQNKRKSQS 237 
Q9P266        152 GPWEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRS 231  human
XP_003786908  154 GPWEVGRRTEHVTKKAAWEEELRASGPAKWQNVSLESWNQPRKLGRQMSDGAGERFFQDLYPFIQGGHMLNSQNKRKSRS 233 
A2VE02        144 GPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQS 223  domestic cattle
XP_008110581  160 GQWEVGGGGEKI-RRTNMQEKWKPSADYRWQTLRTESWDQPTVFGGLVSHGDKERLLQDKYSGRQVNAAATSHAKGKSQS 238 
2_pfamImport  141 GPWEVGGRTEKVTRKATWEEELRTS-PGRWPDGSLESWSQPRQLGRQMSDGGGQRLPHNLYPLGPAEPAWTAQSKRKSRS 219 
3_pfamImport  152 GPWDVRGRTEHVMKKAVWEEEPRMSGPAKWQNVSLESWNQPRKLGRQMSDGGGEKLFQDLYPFIQGEHALTSQNKKKSQS 231 
XP_003468764  152 GPWDVGVRTEYVMKKAVWEEEPRMSGPDKWQNVSLESWNQPRKLGRQMSDGDREKLFQDLYPFTQGEHALTSQNKKKSQS 231 

XP_002919699  233 LPRVLSPESLSCMDIPIPLNDGHFPGVPKMPFHPPNCAPNLESTRNPEKSGSSVPLPRPKFGRPLKPPSYDSHQHSRAgv 312 
1_pfamImport  230 LPRGLSPESLSCMEIPIPVSDGHVPDIPLISPYAPNCVPHLESTRNPEKGGSLTPFARPKFGRPLKPPLYGSHQQTRG-- 307 
XP_014443080  238 LPRVLSPEGLSCTEIPISMGDGHLPGVSKMPPYPPNCAPSLESTRNPDKGGSAGPGPRPKFGRPLKPASFGSHQSRg--v 315 
Q9P266        232 LPRVLSPESLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSRGga 308  human
XP_003786908  234 LPRVLGPENLSCTEIPIPLSDGYL---PKMPPYPPTCPPNLEPTRHPEKGGSSVPLPRPKFGKPLKPPSHGSHQPSRGgv 310 
A2VE02        224 LPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAga 303  domestic cattle
XP_008110581  239 LPRVLSPESLRCVEMPSLITKKHSFSGTKTVSCPPTGL-SLETSRYPNAVAQFLPLPKPKYGRPLKPPSYELHQQTRGsl 317 
2_pfamImport  220 LPRVLSPESLRYMEVPIPFSDGHVPGVPQMLPY-PNCAPSLDCKRNPEKA----PLPRPKFGRPVK----------QGgg 284 
3_pfamImport  232 LPRVLSPESLSYVEVPIALNVGHLPGVPKVPPCPPSGAPHLESTKTSEKAGTSAPFPRPKFGRPLKPPSYSSHSQPRGg- 310 
XP_003468764  232 LPRVLSPESLSYKEIPIPLDDGHLPGIPKVPPYAPNCAPHSELVRNPEKAGSSAPFPRPKFGRPIRP-LYGSHPQPRGg- 309 

XP_002919699  313 ENSDSPDSQRADLCVSYLSRAHEPRLELCASDSGLEPPVYVPPPSYRSPPQPITNPYV-EEAAPRPVCGGPRQQQLAMEL 391 
1_pfamImport  308 ENSDLQGSQQTDPHGSYPTKTNDSRHELSMSDSGLEPPVYVPPPSYRSPPQHIPNPYL-EDTAPRHVSSEHSQPQHLTEK 386 
XP_014443080  316 ESSASQDSLQTDLSVSGSTTAQDPRHELCASDSGLEPPVYVPPPSYRSPPQHIPNPYL-EDTAPRHAHGSHGQPQHAAEK 394 
Q9P266        309 DSSDSQDSQQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYL-EDTVPINVCGGHSQQQSPTEK 379  human
XP_003786908  311 ELSDRQDSRQADLHV--------PRHEPCAVESGLEPPVYVPPPSYRSPPEHIPNPYLeEDPAPRPVCSGHSQQLPLTEK 382 
A2VE02        304 ENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCP-EEAVSRHEGRGRRVPQHPMER 382  domestic cattle
XP_008110581  318 ETNSLQDDLRKDEAISSLTKISDPTQDVCTQDSSLEPPLYVPPPCYKSPAQQSMDQHL-PSEVPDYDMCFNNGIQSPVET 396 
2_pfamImport  285 GHGDPQASQHGAPHVSCWSKANEPRHELCGSDPGLEPPVYVPPPSYRSPPEHIPNPYL-EDAAPTPSSSGHGQQPHLTEK 363 
3_pfamImport  311 ERGSPQDG-------SCFPRTSDPGHEPSAPDCGLEPPVYVPPPSYRSPPLHIPNPYL-EDTMPKHMSGGHSPQHHPIEK 382 
XP_003468764  310 ERSSLQDSQQVDLHSSCLNRTSGPTHEPSVPDCGLEPPVYVPPPSYRSPPQHIPNPYL-EDSVPSYVSGEHGSQHQPTEK 388 

XP_002919699  392 AGASCQLPAGPLGAGNESGASPRSPRGVPQQPRPTTAYDSSVLYIPFDDPRIRHFKLAHPQGFCQETKVDEKSYSSSPGP 471 
1_pfamImport  387 PGASCPRPSGVVGTGNEYRMSPGSPRGLPQFPSPVTAHENSVQYIPFDDPRIRHIKLAKPLGFCEEMKLDDRPYHSGPVT 466 
XP_014443080  395 AGAGCPLPPGPLGTGTEYGAGPRSPRGLPPHPRLAAAFEGSVQYIPFDDPRIRHIKLAQPQGFYEEAKLGPKLWSSDLIP 474 
Q9P266        380 AGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVT 459  human
XP_003786908  383 AGASGQLPPGPFGTGNEYGASPRCPRG-----PSATAHDSFVQYIPFDDPRIRHIKLAQPQGFCEESKLDGKSRNSSPVT 457 
A2VE02        383 PAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLD------GAVP 456  domestic cattle
XP_008110581  397 TNFVHPHSVGIFKSGGEHYQNEPTSYDHKSHPKQVENYLSSVQYIPFDDPRIRHIKIAHTDGLQEDVRAAGDANRTSLYA 476 
2_pfamImport  364 P----RLPSS--GSGDEYGVGQCSP------------CPAGVQYIPFDDPRIRHIKLAWPHGDRQDATPEGSSCGLGPVA 425 
3_pfamImport  383 PRASGPLPPGLLRTGNEYGVSSGSPQSLRPHPRPVATYEGSVQYIPFDDPRIRHIKLAQPLGFGEEVKSDDRPYDACPVP 462 
XP_003468764  389 PGARGPLPPGLLRTRNECDAGPASPQSLPPHPRSVTTHEGSVQYIPFDDPRIRHIKLAQPLGFCEEVKPGDRNYDARPVP 468 

XP_002919699  472 AGAPAPGHSQHDGAVFS-PQSVMTPPGSVRGSTTTDASPRWLWGHLPRDAENGGFSNQREHSAV-RGQWPAAGGSRHGHT 549 
1_pfamImport  467 AQEPAHGKMKCDGALVN-AQGPIPLSENERSLAFADPSPRWLWGQHPGNGEDGNFSDQRDPGIV-REQWTGIRGGQHGRE 544 
XP_014443080  475 PQEPAPGEVLRDGAVLS-PQT-----GYERGATSAQLSPRWLRGHLPRDGEDG-FPEQSDLRVV-R-------GSQHGHA 539 
Q9P266        460 AQEPAHGGMQPDGAIWN-PQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVA-RGQWPDVRGSQHGHT 537  human
XP_003786908  458 PQEPPRGKMQPDGAVWD-PQGLTPLSGDERGLALAGAQPWWLWGQLSRDGEPSGFPDQRDHCVT-RGQRPEVGGSQQRHA 535 
A2VE02        457 APDPR--SLQQEGAVWG-------PSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVtQRKQPDVSGSPQEYP 527  domestic cattle
XP_008110581  477 FQGNSL-EPEYNSAFSDmPDSLSTAVKCDQVPGSSAQSSRWLVEST-IDQDSCALPLQRDS-------YDAGNDLNRKYS 547 
2_pfamImport  426 PPEPARNITQLDGAGRN-PRNPTPPSGDDRGLAFAEPSPQWLWGQLPRNRDNGGPPDPTDHRIT--------RDGEHGHT 496 
3_pfamImport  463 APEPAQGKRHRDGAVLN-AQSLTPTLGTGTGPAFVDPGPWWLWGQLPGDGEYASFPYQ-------RGQPAPGEGGQHGHA 534 
XP_003468764  469 APEPAQERRHHDSAILN-VQSLTPPLGTERRPTLVDPGPQWLWDQLLGDGKNAGVPDQREHCIV-RGQQAPGEGGQHGHA 546 

XP_002919699  550 EGPAPSPSPQG-ESTCETRTKLKKLG--TGTQSKESSRKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSTHKKNGLD 626 
1_pfamImport  545 EGQVSSPDPQS-ESTWEVQTKLRKFE--TGIQTKKTSKKKMNETIFCLVSIPVKSESHLPDIDTNNNDLKQSADKKHRVD 621 
XP_014443080  540 EGQLSSPDAPG-ERTCEMQTKLRTFE--TGMQTKKSSKKKTSETIFCLVSIPVKSESHLPATDTNNNDLKPTADRKDGCD 616 
Q9P266        538 GRQVSSPYSQG-ESTCETQTKLKKFQ--TGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQKNGSD 614  human
XP_003786908  536 EGQVSSPHLQG-ASTCETQAKLKKFE--AGIQTRKSSKKKTNETIFCLVSIPVKSESHLPDIDTNNNDLKQGGDKKNGSD 612 
A2VE02        528 ESLVSSPSPQG-ESSCEMQTQLRKFE--AGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSA------- 597  domestic cattle
XP_008110581  548 KGRLSVQSPHT-QLPCETITKVKTFEpgTEIQSKKSSKKKTNETIFCLVSIPVKSDLNLPDTDRNNN-VTQGAEEKNGLD 625 
2_pfamImport  497 EGLVSRASPHG-ESLCETQAKLKKSE--TGPELKRRSKKKVNETIFCLVSIPVKSESQLPDTDRNNNDLKQGARQVNGAD 573 
3_pfamImport  535 GSHVFSPDPQRsERTCETQTKLRMFA--TGMQTKKSSKRKPNETVFCLVSIPVKSESHLPAIDRNNNDLKQSADQKPGAD 612 
XP_003468764  547 GGYVSSPDPQGsERTCETHTKLRMFE--TGMQTKKSSKKKTNETIFCLVSIPVKSESHLPEIDTNNNDLKQSADKKPGID 624 

XP_002919699  627 KSTVLQEQSLLSMSSTDLELQALTGSMAGRTEFQKQDLGEPEEGKQTNDLRFIHPTKHRELKYSGSWPGHQYRDQQTQTT 706 
1_pfamImport  622 KSTALQEQSLLSTSSTDLELQALTGSMVGRTEFTKLDLGEPEEDKQTHDLRFIHLAKHREFKYSSPWPGHQYKDQQTQTN 701 
XP_014443080  617 KSAALQEQSLLSLSSTDLELQALTGSMVGGTGFRKQDLGEPEVHKQTNDLRFIHLTKHRELQASGFWPGHQYRDQQTQTS 696 
Q9P266        615 KSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTS 694  human
XP_003786908  613 KSAALQEQSLLSLSSTDLELQALTGSMGGRPEFQKQDLGEPEDDKQTNDLRFVHFTQHRELKYAGSWPGHQYRDQQTQTS 692 
A2VE02        598 ---SLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTS 674  domestic cattle
XP_008110581  626 NSGVLREQSLLSTSSTDLELQALTGSMTNKNELQKQESWKPK-FKQMNDLRFLQPAKHKELQYSGSWPGDQYKDQQTQTS 704 
2_pfamImport  574 KSP-------LSASCTDLELQALTGSLVGRPALCTQAPGEPEKDRHANDLRFLYLTGHTELTYPGVWPGHQYRDQQTQTS 646 
3_pfamImport  613 KSLALQEQSLLSLSSSDLELQALTGSMAGQTEFPKQGLGVPG-DRHADELRFIHLAEHRALQYSGSWPGHQYRDQQTQTS 691 
XP_003468764  625 KSLALQEQSLLSMSSTDLELQALTGSMAGKTEFPKQDQEEPEGDKQTDDFRFIHLAKHRALKYSGSWPGNQYRDQQTQTS 704 

XP_002919699  707 FTEDTKSPQPLPAEKAGGSPKAVLTPRFSDPVASKPHVPVALASSDQNQRPKAPPLKGQMS-LSPSNNSAFSRTTSCI-- 783 
1_pfamImport  702 FSEESQRSQLLPDENVGGMSNTAPASKSIEPPASRALLHTALVSGDQNQKPDAHSLKGQMS-LSPSSNSAFSRTSSSVns 780 
XP_014443080  697 FPEESQGTQLPPGAEHRGPSPSTPGAKCPEPAAFEPHVHTALASRDQKQKPSAPSPQGQTS-LSPSSNSAFSRTSWSV-- 773 
Q9P266        695 FSEEPQSSQLLPGAKLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRS-LSPSSNSAFSRTSLSV-- 771  human
XP_003786908  693 FPEESQSVQLLPGAQPGGPSDTGPAPQHPDPAASEGQMHTALASGDHRQRPSAHPLRGQRS-LSPSGNSVFSRTSSST-- 769 
A2VE02        675 FAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGS-LSPSSNSAFSGSSWPR-- 751  domestic cattle
XP_008110581  705 FTEDPKVMQLLQGLEHKRSNTTRASQVLRDGTSTTKPTLTVQSADNRQGKQFTSSVKEQGK----ASNSVYSRTV----- 775 
2_pfamImport  647 FPEEPKSSQ--QPTELGAAGHVAPTPRRADPAASDPGTHTVACAS----RDHAQNLQGQASpLSPASNSAFSRASSSS-- 718 
3_pfamImport  692 FPEDSKSSQLLPAARLGDLSDTAPDPKCLDPTASDLPVHVALGSSDPNWKACAPHPKGQMS-LSPSSHSAFSRTSPSA-- 768 
XP_003468764  705 FPEESKSSQLLPASMLGELSDTAPMPERLE--ATGSHRHVPFGSSDQKQKAYAPNLKGQTS-LNPSSNSAFSRTSPTT-- 779 

XP_002919699  784 -----------HQAPAPKAGPGRACVDGQGRGSSPGPRGEVVKGET-TGPCNSRQLFGQFLLKPVSRRPWDLISQLESFN 851 
1_pfamImport  781 nsafsrtsssvNQALVPKVGQSQPCVGVQEHEAHPAPKPEVVKGEPmAGPCNSKQPFGQFLLKPVSRRPWDLISQLESFN 860 
XP_014443080  774 -----------NQAPVSKACPREPCADVRVPAASPGPQREVVKGEP-TGPCNSQQLFGQFLLKPVSRRPWDLISQLESFN 841 
Q9P266        772 -----------DQAPTPKAGRSQPCVDVHGLGAHPGPKREVVKGEP-TGPCNSKQLFGQFLLKPVSRRPWDLISQLESFN 839  human
XP_003786908  770 -----------HQAPAPKAGRSQPSVDVQGHGASPKPLCEVVKGEP-TGPCNSKQLFGQFLLKPVSRRPWDLISQLESFN 837 
A2VE02        752 -----------NQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGET-TGPCNSRQLFGQFLLKPVSRRPWDLISQLESFN 819  domestic cattle
XP_008110581  776 -------------VLNPKASPNLPPASSATFPGQEKDSNSVFVEEE-STLSRSKELFGQFLLKPVSRRPWDIISELESFN 841 
2_pfamImport  719 -----------SSTTWAPAAKAGPSVDGR------APQPEVVKGETaAGSCNSQQPFGQFLLKPVSRRPWDLISQLESFN 781 
3_pfamImport  769 -----------TQAPVPKAGQTQPCMDVRGQGASPVPKPEVVKGEStAGPCNSKQLFGQFLLKPVSRRPWDLISQLESFN 837 
XP_003468764  780 -----------SQAPVLKAGQPHPCLDVRGQGASPVPKPEVVKGEPtAGPCNSKQLFGQFLLKPVSRRPWDLISQLESFN 848 

XP_002919699  852 KELQEEEECgq---sgSDSRSEDSDTEWPCEGYADATGKNWGWREDsga----wrAEDPRKRLALEEPGAQPGRVKSKSE 924 
1_pfamImport  861 KELQEEEES-------YNSSLEESETEQQQEDYADSGPRNQGFHEN---------KEQQPRVLVPEDSGFHLGRIISRFE 924 
XP_014443080  842 KELQEEEEEe-----dSHSSSEDSEAEWLQEDPADPRPESSGFHRHgqe----vrVEQEPRMLVPEDPAWL-GRVQSKPE 911 
Q9P266        840 KELQEEEESsss-sssSSSSSEESEAEPQQENRAHCRQEDVGFRGNspe----mrVEPQPRMWVPESPVCRSGRGESKSE 914  human
XP_003786908  838 KELQEGEESsss-sssSSSSSEDSEAEHQREDHAGSRPENPSSPGHspg----lrAELQSGAWVLEPPVWLSGREERQSE 912 
A2VE02        820 KELQEEEGSsgs--ssDGSGSEDSDTELPWGSCARPAPQLPGLLKD----------------IVPEDPRTRPGRVKSKSE 881  domestic cattle
XP_008110581  842 KELQEEEES-------SEDGIENDGRQEREKEEKIGRKESVAFRNDemsqepdhrLGTQSEPLIAVTPVCAQDKDKSRSE 914 
2_pfamImport  782 KELQEEEEShpdsdgrRGSGSEGSEGQGPWEDGDPSLEKHPGFPEShre----erEERQPKAWGPQHPEFRSGGAKSQSG 857 
3_pfamImport  838 KELQEEEDSpd---gsSGSSSEENEIEQRQEDCVGSRPRSWGFHEDscd----grGEQQPRRLVLEDRGGWWGRVERGCE 910 
XP_003468764  849 KELQEGEDSpd---gsSGSSGEENEIE-RQEDYVDSRPRNWGFYEDse-----ksVKPPPRELVLEHPERWSGRVKSKSE 919 

XP_002919699  925 SWSEEQKPSRPRAPPQSpPGPTTTVGGG-------------AEDYPWAHGSLVTQEGHQDVEQRMNKLAVSPGPVHRVMS 991 
1_pfamImport  925 SWSEEPNPGHPCARPQF-PGPLQVEDSR-------------IGPFQLADGGLLTEKERQKVVNGMNEQLISPGPVKRMMS 990 
XP_014443080  912 SWSGEPKPGLPHAQPQS-SGPTQGGDGR-------------GEPWQSVGWSPATEERRREDGSGESRLALSPGPEKGRVS 977 
Q9P266        915 SWSEELQPGHPRAWPPS-PGRFRVEEGG-------------GAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTR-MS 979  human
XP_003786908  913 PWSEGPGAS---SSPR--PAPSQVECGR-------------GDSFWLADGSW-----NNEVDREVNEPVVSPGPVQGLVS 969 
A2VE02        882 SWSEEGR-------PRS-PRPWQAE-GR-------------GSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAIS 939  domestic cattle
XP_008110581  915 SVSASESSN------------TRVTGGEfhvssrclqareiGESTKVTNGYLFAEPKKQEAGKRIIKHAVSPQTTKRILS 982 
2_pfamImport  858 GWSEQVAPGWPQACPRSpRGPPQAEDGR-------------GAVFLAADGGAIIEKRDQAEGRSAREPVHSPSPPRRAES 924 
3_pfamImport  911 TWSREPGAGHPLAHPPS-PGFSQVEDGR-------------GQPFGSAGGSLVTETREWAMVNGTDGPPGGPGPGRRGAS 976 
XP_003468764  920 SWSEELKAGHLSTCPQS-PDFSKVKDSR-------------SDPFGSADGSLVTENRKQEIVNGLDELIARPGPVKRVVS 985 

XP_002919699  992 SRSSDANPVPSSHAAELRPPQGSQDLPN-----ASLSGELSTPTPRTTGaGGERSPLLPLSLASKPRGLSAPDLRSVGLL 1066
1_pfamImport  991 SRPSDTKPAPLSYLAESKEPPESLKLTN-----ALSSVQLNKGVSLKND-GKEKDTVVPLSLTVKNRGLSAPDLRSVGLT 1064
XP_014443080  978 SRSSDTKPSLLSYLAEPREPQDSWEFTS-----AVSSTRPSHMLPRTAD-GEERGTAVPLSFTDKSRGLSAPDLRSLGLP 1051
Q9P266        980 SRSSDAKPLPASYPAEPREPQESPKITS-----AFSSVKPSEAVPRKFDsGGERGAGLPLSLSNKNRGLSAPDLRSVGLT 1054 human
XP_003786908  970 SRSSGQKPVSPPSPAEPREPQEIQKLIG-----AFTSAKPSIAGPPRVDsGRQRGAVLSRSLTGKNRGLSAPDLRLVGLA 1044
A2VE02        940 SGLNDAKPEPPPDPAEQREPLPSQELPG-----SRGAVELSAAGPPRAGgGEQGSTRAPLSLAGKSRGLSAPDLRSVGLT 1014 domestic cattle
XP_008110581  983 DSYDDENHYNPFNSFNFRDESHVKNES------VVDFDRLKKNAAPRINlALERGSATRLSLTNRSQGLSEPDLRSVGLD 1056
2_pfamImport  925 SRASDAWPAAPACAAGLREPTR-----------DASALRVSGAAPPEAG-----ETPAPLPLAARSRGLSAPDLRCVGL- 987 
3_pfamImport  977 SRASDTRPVPPAWLAAPREPAESERLTDewlpgALGSVWQSGVVPPELPgAEEGATEAPLTLTSKGRGLSEPDLRSIGLM 1056
XP_003468764  986 FRQSDTKPVSPSWLAEPKEPAQREKLTD-----AFTSVQLREEAPLEVGlAEERGTGVPLTLTNKSRGLSAPDLRSVGLI 1060

XP_002919699 1067 PAQEQSAHKLDGSLGEASAIEIP--PNESLQARAARILGIEVAVESLLPGArRTGQNQHPEP--DGSARGPEAPREGSES 1142
1_pfamImport 1065 MGQEQNVSKLDGSLGKGRATEIP--QEESLQERAERILGIEVAVESLLRGT-RTGQNEPPKS--DTSACSPESSKEKSLP 1139
XP_014443080 1052 AGQEQETPGLDGTLGEARAVAAP--PSESLQARAARILGIEVAMESLLPGArKEGQSQLPEPvtNTNTCSPGPCMEELPV 1129
Q9P266       1055 PGQEQGASELEGSLGEASTIEIP--PGESLQARAARILGIEVAVESLLPGIrRAGQNQPAEP--DASACTPESPQEELLS 1130 human
XP_003786908 1045 PGQEQSTSQVDGSSGE--AIEIP--PGESLQARAARILGIEVAVETLLWGSrRAGQSQPPLP--DASACSPESPRDEPSS 1118
A2VE02       1015 LVQEHSTSQLAGSPGDANAIEIP--PNESLEARAARILGIEVAVESLLPGAqRAGQRRHPEP--DGSALRPESPRQEAAA 1090 domestic cattle
XP_008110581 1057 EDQGPGTCELD-CYGKPIVPEIP--PNESLQARAARILGIEVPVEALVPNN-RTIQDKNLHS--DNFSLKLSAERTLGDM 1130
2_pfamImport  988 --REQHPIGSDGSWGDSSAAEIP--PGETLQARAARILGIEVAVESLLPDSsRTRQSQRPEP-----------PREASQA 1052
3_pfamImport 1057 MRPEPSASKLDRPLGEGRAAVIPpsPNESLQARAARILGIEVAMESLLPGTgTAGPSQSTEP--DTSVCSLEPPREGPLP 1134
XP_003468764 1061 MRPEPSTSELDRPLGESTAAEIP--PSESLQARAARILGIEVAMESLLPGTrTAGLSQSPEP--DASTCSLEPLREESSP 1136

XP_002919699 1143 S-SAQPDDPPASMDAFYGRRKCGWTESPLFVGErdsarRPPPAAEHSRVDRTVPSKAPSPEPQPSPQESQSFNPKDMGTK 1221
1_pfamImport 1140 S-SVPSDAPLVTTDAFYGRRKCGWTESPLFVGE-----RAPQTCEPLNVDGVLTSQPTSPEPQPNHLESKSFEPKDVGAK 1213
XP_014443080 1130 S-PAPAGGPPAPADAFYGRRKCGWTQSPLFVGErdgarRAPQASEHMGVDGL---RAPSPEPQPDPGELKTFDPKDEEAR 1205
Q9P266       1131 R-PAPADVPRVSTDAFYGRRKCGWTKSPLFVGDrdsarRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKFFEQKDVETK 1209 human
XP_003786908 1119 SgSAPADVLTVPTDAFYGRRKCGWTQSPLFVGErdsarRASPMSDQSSVDGVITSEASSPEPPLNLLESRSFNQKDMGAR 1198
A2VE02       1091 S-LAQPNESTAPADAFYGRRKCGWTKSPLFVGErdstrQVPRASEPADVDGAVPTKA--PETPPSPLESQPFLPKDVETK 1167 domestic cattle
XP_008110581 1131 T--------ETKVTSFEGRRKCGWTESSFFVG-----------------DNISLESTEDQIPGEETLIAEHFEQHESLSR 1185
2_pfamImport 1053 S-SAPSDGPTATADAFYGRRKCGWTESPLFVGEregtrRGPPAPEPSAADGVLAGQVPSPEPQPDALEPKPSECRAGGLA 1131
3_pfamImport 1135 S---------VTADASYGRRKCGWTQSPLFVGE-----RAPQAPGHSAVGR----DLASPEPQLGSLESRSSEQKDAGPN 1196
XP_003468764 1137 S-SAMSFGPTATTDAFYGRRRCGWTHSPLFVGE-----RAPQASEHSAVDRVPTSQDTSPEPQLGPLESKPLEQNLVEPK 1210

XP_002919699 1222 ------SPFRSTLFHFIERTPNVSGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADTME 1295
1_pfamImport 1214 ------PPFRSTLFHFIERTPNVAGSEKRLRNPSKAIESLQEKLASPQRRADPDRLIRMKEVSSVSRMRCLSFKNMDSAG 1287
XP_014443080 1206 ------PSFRSTLFHVIERTPSVSGPEKKLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVTSVSRMRFLSSKTPDSTE 1279
Q9P266       1210 ------PPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQE 1283 human
XP_003786908 1199 ------PPFRSTLFHFIERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRAAPDRLLRMKEVSSVSRMRVLSCRSTDSTE 1272
A2VE02       1168 ------PPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEVSSVSRMRLLTSRAADS-- 1239 domestic cattle
XP_008110581 1186 qredhiPSLESAVLPFVERQVVPPNAEKKGRNTSKVIETLQGKLAASPSRAAMDRLVRMKEVHSVSRMRRLSIKNTDSGE 1265
2_pfamImport 1132 ------PSFRSTLFHVIERTPGAAGSEKRLRSPSKVIESLQEKLAAPPRRADPGRLMRMKEVSSVSRMRCLSFQSADRAA 1205
3_pfamImport 1197 ------PPFRTTLFHVIERTPSMLGLEKRLRGPSKVIESLQEKLASSPRRADPDRLMRMKEVSSVSRMRSLSFRSADPTT 1270
XP_003468764 1211 ------PPFKSTLFHVIERTPSVSGLEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRSLSCRSTESSE 1284

XP_002919699 1296 EAEGLKA-ERGPGEPPGGPVSLNAGDMARKAGHPLSVSGGAPSLEEDGPPSAQREKtTVRQDFWCP 1360
1_pfamImport 1288 EAEELNV-PGNQASQPGGPVSLSSGDRSWRAGHLPSVSKDVISQEENGHLAGQRERkNTDQGFWCP 1352
XP_014443080 1280 ETEELKV-TRGQAGPPEAFVSLNGRDWARRPGHLLPVSKSIISQEENGHPATQRQRrTAEQDFWGP 1344
Q9P266       1284 DAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEK-SMDQDFWCP 1348 human
XP_003786908 1273 ETEELTA-IRGQPGPPRGSSE----------DHTVSGSKQGTSWGESERPAM--EKkDGDQDFWCP 1325
A2VE02       1240 -AEEPKA-ERGPGAWLGGLVAPS-------AGHKLSDPQGALSLEADGHPAARRE--NGGRDFWCP 1294 domestic cattle
XP_008110581 1266 DGEEEKQ-PKGLDERGSDPTSEN-NELPRKLSHRSSVSKRIISLAENGLLDNRNEKkTGKHSFSLD 1329
2_pfamImport 1206 E----------EAGQPAGCGSPRGGDRAHPRGLSSAPARGGVSWEDLGHPAAQRDR-IASEDSWCP 1260
3_pfamImport 1271 EAEEAKA-AGGQALQP-----LSRGDRAWRAGPPPALSEGLITWEENGTVAAPRER-SEAQHFWCP 1329
XP_003468764 1285 EAEELKA-ERGQAWQPGGPMALSRGDRAWRVGHPPSIPKGIVTWEENGHVASQKEK-STSQDFWCP 1348
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