Conserved Protein Domain Family
GEMIN8
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pfam15348: GEMIN8 (This model is not part of the current CDD release)
Gemini of Cajal bodies-associated protein 8
GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.
Links
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Statistics
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PSSM-Id: 521796
Aligned: 26 rows
Threshold Bit Score: 265.761
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006153774  13 AWYSHPVYARYWQQHQQAKAWMRSHQVAYRKAVESYFSSPCYLAfrrs-------------------------------- 60 
Q1LZ79        13 SWSSHPVYARYWQHYHQAMAWMRSHQSAYQKAVESVVTSPWYYPatdlaqspaakggtspksrskspsasgdacrrrsrp 92  domestic cattle
XP_028935981  11 PWYSRPVYARFWQHYSQAMHWMHRHKIAYRKAIESFYSLPSHRPepppsgryadwsgddlpa--------pgwprksghl 82 
XP_007500969  10 PWYSQRAYARYWQHYNQAMQWMRRHQSAYRKAMLSFYNSPWYLPallpssryadwggddqaaqeg-rlpstgwhsrspys 88 
XP_003218936  84 PWHSQKIYARYWKHYNQAMEWMYRHRNAYNKAMEFLYNQSFCPPadhpssryadwdegeh------------lheqaftq 151
XP_012812585  11 PWYAGRVYARYWKHYSQAMYWLYRHKRAYSVAMASLSYPSWYPAgnvqnrrysdweggkssqsd----iylrphrqvihp 86 
XP_416829     13 PWYSQKMYARYWKHYDLAMRWMHRHQEAYRKAMESFYHVPWPPYaaspsrrysdwdgddppc-------thnrfsnyspr 85 
XP_005996189  14 PWYAHQMYSRYWRHYHQAMHWLHRHKEAYRKAVESFYYLLWHSRmtaeghryadwsdderpvrrs-hcpselgrvnqres 92 
XP_015217242  10 PWYSHPLYARYWSHYQQAAHWQHKHWQAYRKALEAAYCVPYRAEgaavarrhssgse-----------------resagp 72 
XP_005463147  10 SWFSSPVYSRYWQHYQQAMAWHQRHRRAYRKALEAAYGPCCYQEegrsdrar---------------------------- 61 

XP_006153774  61 ---gqhaYDSSRTQTSTVE--DQALFKEEE----AESES-EEEVEYDLSNREVTEELRQYFVETERHREERQRQQQLEAA 130
Q1LZ79        93 gkpgpqrRSTEKPARFAED---------------NDSESdDCGIVCDLSNMVITDELRQYFAETEQHREELRRQHQLDAA 157 domestic cattle
XP_028935981  83 hwsgprpDTGRDCQGTTEEdrGSTTe--------EESES-DGEIECDLSNMEITEELRQYFAETERHREELRRQQQLEAD 153
XP_007500969  89 rwsqqppAHAHSHRMTSKEnqAPSTe--------EESDS-DGEIECDLSNMEITEELRQYFAETERHREELKRQQQLEAQ 159
XP_003218936 152 nrptryyPRSRQAPYNTKRrqTVEMVLETD----SESES-EGDVEYDLSNMEITEELRQYFEQTERHREELRKQQQLEAE 226
XP_012812585  87 qrtrpclKVSESKEIESEMecDKEVTSDSE----------EEGIECDTTNMEITEELRQYFAETERHREELRKQQQLEAE 156
XP_416829     86 graqqymDAQPGKEDDDRE--EEEEDSEVE----EDSES-EGEFEYDLSNMEITEELRQFFAQTERHREELRRQQQLEAE 158
XP_005996189  93 qsqrwqyPTPSSKHQASEEkeSTSEDEEDD----DDSGS-GDEIECDVSNMEITEELRQYFAQTERHREELRRQQQLEAE 167
XP_015217242  73 eacprfpSGGKRGPSASRRaaGTKRVRCSRdg-eENSSS-DGEVECDVSNMEITEELRQYFAETERHREERRKQQQLEEE 150
XP_005463147  62 ----------------yadwssaeSNSEDEeggvEESSS-ESEIECDVSNMEISEELRQYFAQTERHKEELKKQQQMEAE 124

XP_006153774 131 RLDDYVNADHGLYYKPC-RAVGPPAQRPGEQRKAEMQHLYRDSTAKILAMEAAVQLR-SKHCDRKQPRYWPVIPLKF 205
Q1LZ79       158 RLKDYVNADHGLYCDKRgRSTLPPTERPGERRQAEMKRLYGASAAKIQAMETAMQLSfDKHCDRKQPKYWPVIPLKF 234 domestic cattle
XP_028935981 154 SQDVYVEADHDLHLPTR-RSVQPPAERPGERRMAEMKKLYGDSAAKILAMETAMQLNfDKGCDQKQPKYWPVIPLKL 229
XP_007500969 160 HQDVYVEADHDLHQTTG-RSVQPPSERPGERRMVEMKKLYGDSAAKIQAMETAMQLTfDKNCDKKQPKYWPVIPLKL 235
XP_003218936 227 HHDMYVEADHDLHLSTG-RSTQPPAEKAGERRTAEMRKLYGVGANKIQAMETTMQLSfDRNCDKKQPKYWPIIPLKL 302
XP_012812585 157 NHEQYIAADHDLHVATR-TSKEPPSERPGERRRAEMKKLYGEDAPKILGMETAMQLNfDRHCDKKQPKYWPIIPLKL 232
XP_416829    159 QQEMYVEADQDLYRNMK-RSVEPPAERPGERRVAEMEKLYGDEAAKILAMETAMQLIfDRNCDKKQPKYWPIIPLKL 234
XP_005996189 168 CQDSYVAADHDLHVSAG-RTVQPPTERPGERRVAEMKRLYGEDAAKIQGMETAMQLTfDRNCDKKQPKYWPIIPLKL 243
XP_015217242 151 QQSAYVPADHDLYRVAR-RSAQPPRDQPGVRRGIEMKMLYGEDAAKIQGMETAMQLTfDRNCDLKQPKYWPVIPLKL 226
XP_005463147 125 QQGSYVPADQDLHSFSLqSSVAPPLERPGERRTAEMKKLYGGDAAKIMAMEAAMQLNfERNCDLKQPKYWPVIPLKL 201
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