Conserved Protein Domain Family
DEPP
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pfam15343: DEPP 
Decidual protein induced by progesterone family
DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester. Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.
Links
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Statistics
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PSSM-Id: 464661
Aligned: 13 rows
Threshold Bit Score: 256.671
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012400432 111 DELQSDLLSSQSLDDYVKSICQLAQPTSVLDGDq-RLPYNRLRKPcrlrgktfndstsASHSEKSSPASPMQDITAHFSG 189
XP_003513161  26 APGQEEPPNSPSLDDYVRSICQLAQPTSVLDKI--RSRPHRPYRP-------------AWTREKRCQAESVADSSPCFSS 90 
Q5BMD4        25 GAPGQEPPASPSLDDYVRCICQLAQPTSVLDKAtaWSPPNRSCRP-------------AWPREKRHQSESLEDSSPCFSS 91  Norway rat
XP_002722573  26 GGLGQEPPASPSLDDYVRSICQLAQPTCVLDKAtvQDGLSGPHRP-------------AWGLEETCPTATLQDSTARFGA 92 
2_pfamImport   1 GGTGQDPPASPSLDDYVRSICQLAQPTSLLDKVtaRSRPSRPHRS-------------PRSSEKSHPAASLQDNTASFGG 67 
Q5RBE4        25 GGPGQEPPPSPSLDDYVRSISRLAQPTSVLDKAtaQGQPRPPHRP-------------AQACRKGRPAVSLRDITARFSG 91  Sumatran orangutan
XP_006097602  25 GGPRQDPLASPSLDDYRRSICQLAQPTSALTEAaaRAQPSRRPWQ-------------ARAGEKSGSPGSLQDFTTPFSS 91 
1_pfamImport   1 GGPGQEPPASPSLDDYVKSICQLAQPTSVLDMAtaRAQPSRTLRP-------------AQAFKKNCPTESLQDITTHFSG 67 
XP_004749786  25 GGPGQEPPASPSLDDYVKSICQLAQPTSVLDVAtvRAQPGRTPRP-------------ARAFRKSPPTESLQDITTRFSG 91 
XP_003359328  25 VGPGEEPPASPSLDDYVRSICQLAQPTSVLDEAaaWARPRRPHRP-------------GRSCEKSRSDGSLQDITTHFSG 91 
Q1RMP5        25 GGAGEEPPASPSLDDYVRSICQLAQPTSVLDEAaaRVRTSRPHRI-------------ARSCAKSCPTGSLQDITTRFTG 91  cattle
XP_010587595  23 LSRGPEPPPSPSLDDYVRSICQLAQPASVLDEApaGDRPSRLHRP-------------ARACERSHPAMSLQDIPTCFSG 89 
XP_007478166  32 DELQSDLLSSQSLDDYVKSICQLAQPTSVLDGAq-RLPYTRPWRPcklrgktfndaslASHSEKSCPTSSLQDITARFSG 110

XP_012400432 190 QHSTLPLGNNIDPLDWLFGESQPKRQSWKDTLRRTGlSTDPSCLHKQNEPGksrvprRIRACEAKLPGGPLTKLSSEWGK 269
XP_003513161  91 LQPPLPSPGTDNPLDWLFGKSQEQQADRRDLPNGPD-SSDHWGVHRQMEEN------RGRLCEARLPENSPGRKSGHRQQ 163
Q5BMD4        92 LQPTLPAPGTDNPLDWLFGKSQEQQTDRRDLPNRTG-SSGHWGVHRQMGKD------SGRPSEARVPEYSLGRKPGHRHQ 164 Norway rat
XP_002722573  93 QQPPRPTAGPADPLDWLFGESQEKQSSRRQPARRTGaSAGLGGLHRQTDSGktravpRGKLCEARAPGHSLARTSRDGPQ 172
2_pfamImport  68 QQSTLPSAGTTDPLDWIFGESQRNETNRRDLLRRTGpSAGHWRAHREANSG------KRRLFEARAFGHSLTRPSQDVHQ 141
Q5RBE4        92 QQPTLPMADTVDPLDWLFGESQEKQPSQRDLPRRTGpSAGLWGPHRQMDSSkpmgapRGRLCEARMPGHSLARPPQDGQQ 171 Sumatran orangutan
XP_006097602  92 QQPP----NTADPLNWLFGQSQEKQPRRRDLPRRTGpSADPWGPHREMESTkaggcpRGKLYDARAPGHCPVGQLRDWHQ 167
1_pfamImport  68 QQPAPTRDCTADPLDWLFGDSQEKQPSRRDPPRTTGsSADPWGPHRQMDGGkaqgtsRGRFCDASVQEHSLVRPSRDWHQ 147
XP_004749786  92 QQPALPGDGTADPLDWLFGESQEKRSSRRDQPRRTGsSADSWGPHKQMDCGkargtpRGRPWDARVQGHPLARPSRDWHQ 171
XP_003359328  92 QQPVLPRAGPADPLDWLFGESQEKRPSRRDLPRRTGlPADPQALRKETNSGkaqggpKGRLCEARAPEHSLERPLRNWHQ 171
Q1RMP5        92 QQPSLPRTGTVDPLDWLFGESQEKQPSKRDVPRRTGpSADPWASRRQTDSGkapgtpRGRLSDAKAPGHSLQRTSRDWHQ 171 cattle
XP_010587595  90 QGPLLPRVGTADPLDWLFGESQEKQPTRKDLLRRTGlSANPWGLHRQTDTGkarsgpKARFCDARAPGHSLARLPQGRHL 169
XP_007478166 111 QNLTLPLGNNTDPLDWLFGESQTKRQSWKDALRRTGsATDPSPLHKQTETGksrvarRVRACEAKVSGGPLGKLSTD--K 188

XP_012400432 270 VWEKRTQPSMLNASLKYSSSSHQDR--ISRVLNSNLPVIYEL 309
XP_003513161 164 TSDRKSWTSRKSHQALAAVSGSRPSs-ILSTLCLHLPVIHEL 204
Q5BMD4       165 TSNLKSWTSRKPCQALASVSSSRPSs-ILGTLYLHLPVIHEL 205 Norway rat
XP_002722573 173 SANLRSHMAGRPSRATDSSYSPRPSs-ILRTFYLHLPVIHEL 213
2_pfamImport 142 SSNLNNWASGQPGRATASPCNPRPSs-ILRSLYLHLPVIHEL 182
Q5RBE4       172 SSDLRSWTFGQSAQAMASRHRPRPSs-VLRTLYSHLPVIHEL 212 Sumatran orangutan
XP_006097602 168 GS----RASRQPIRAAAPPPSSRPSs-VLRTLYLHLPVIHEL 204
1_pfamImport 148 CS----WASRQFSGAAASPPAPRPSs-TLRTLYVHLPVIHEL 184
XP_004749786 172 GS----WASRQLCTDVASPPAPRPRs-TLRTLYLHLPVIHEL 208
XP_003359328 172 CS----PASVQPGRDAASSTSPRRSs-ILRTLYLHLPVIHEL 208
Q1RMP5       172 CS----QASGQPGQDAGSPTSPRHSs-ILRTLSLHLPVIHEL 208 cattle
XP_010587595 170 SS---SWDSRQ----------PRSSgsVLRALHSDLPVIHEL 198
XP_007478166 189 ALEKRTQPSALNAALEYSSNSHQGR--IPRSLNSNLPVIYEL 228
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