7WTS


Conserved Protein Domain Family
SLX9
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pfam15341: SLX9 (This model is not part of the current CDD release)
Ribosome biogenesis protein SLX9
SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.
Links
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Statistics
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PSSM-Id: 521791
Aligned: 127 rows
Threshold Bit Score: 48.0607
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7WTS_z        99 KTVLPKKEKMKLRREQWLQKIEAik---------------lAEQKHREErRrraTVVVGDLHPLRDALPELl-------- 155 human
XP_003645137  42 QAREAKKEKQLNKSRSFLTKIREqandnv-------gisksALRRRKRKqR---DDLKPKMQDLLLSLQDEgvl-----d 106
XP_003959632  44 QPKETKREKQLNKQSAFISRVQEksmgmdps---fagisksSIRRRKRKmR---DNLKPRMDDLLVSLEREddlrditqn 117
XP_056087849  47 QPKETKKEKLLNRQNTFLSQLKErsmlgdrananldgisksSVRRRKRKlR---EELKPRMQDLLTSLEQEkdlqgimee 123
XP_003680646  42 QPRESKKDKQNNKQQNFLNRVLAkatgqdq----fagisksAVRRRKRKlR---EDLKPKMGDLLTSLGQEddlkehvqe 114
XP_003671160  55 QARESKKDKQLNKQLSFLSKMKSkstgkesn---fdgisksSIRRRKRKlR---DDLKPKMEDLLTSLAQEqdlkehvrn 128
CCE79127      48 LSTVAKKDKQASRSSNFTQRVITkaadng------mgisksALRRRKRKaR---EQLKPKMDDLLASLS----------- 107
Q6BMZ5        48 LSKVTKKDKQLNKSQNFSQKFDSstlnts------snisksALRRRKRNaR---NELKPKMDELLQNLP----------- 107 Debaryomyces ha...
XP_007374637   4 LAKTSKKEKQQTKSNNFTAKLMNkvtfnts-----nnlsksALRRKKRReK---EQLKPKMDELFSSLP----------- 64 
XP_006685463  43 LSSITKKEKQHQKTKSFTQRLATtsss----------vsksALRRRKRKvK---EALKPKMEELFETLPevtrdqq---- 105

7WTS_z       156 -gLE----AGSRRqarsre---------------snkprP--SELSRMSAAQRQQLLEE-ERTRFQELLASPAYRASPLV 212 human
XP_003645137 107 kdGNvqdgSFGPSstvtsikkssgydgihnvvaeesgtvPvkKNEPSMRTQRGAKLLAKnEAVRFAQVISDQGFKKDPFA 186
XP_003959632 118 tgEHaddeETRKRnranvtkvv---------srnepgsvLtrRNEPSIRNKKGAKTLQIkETERFNQVLKNQLFQTNTFG 188
XP_056087849 124 ssAAvdgdDEITMdsrirfvdtke----lhskkaepgsiRikKNQPNMRNQKGAKALAAnETARFSQVLTNEDFQKNPFG 199
XP_003680646 115 eiVDekvqVEEPRrnvtkivsik------nqdhadpgfvKirKNEPNIRNQKGAKVLSIrETTRMNNVLHNASFQQNPFG 188
XP_003671160 129 nqRQrddrRGHDVlcqpkllnllsm--rnytnmnepgsvIikKNQPNIRNQKGAKALSQlESKRFTQVLTNQTFQQNPFA 206
CCE79127     108 ----------EPTttivdsdavka----hatddhsyisqNknKNQPNITKQSGHRIIMNdERKNFTSLLRDSQFRSSPFA 173
Q6BMZ5       108 ------------EttnvidpsaaahkpndhkstkfikstKasANLPNATKQTGHAKIMTqESKNFTNVLKNPQFRSSPFS 175 Debaryomyces ha...
XP_007374637  65 ----------ETStntditnntttkivtassgegfikssKsnLNKPNPSKSSGFKQILKdEHKNFNNVLKNPQFRTSPFD 134
XP_006685463 106 --------------------------------tgfvpsdTphANEPNARKKTGHQVIFKrEHENFNHILQNKQFRTSPFA 153

7WTS_z       213 AIGQTLARQ 221 human
XP_003645137 187 TLREVIKMR 195
XP_003959632 189 ALREVIKMQ 197
XP_056087849 200 ALREVIKLQ 208
XP_003680646 189 ALRDVIKMQ 197
XP_003671160 207 SLREIIKMQ 215
CCE79127     174 ALKDAIANK 182
Q6BMZ5       176 ALKDAIAQN 184 Debaryomyces hansenii CBS767
XP_007374637 135 ALRNAIQQN 143
XP_006685463 154 TLKQSIQEN 162
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