Conserved Protein Domain Family
Afaf

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pfam15339: Afaf 
Acrosome formation-associated factor
Afaf is a family of single pass type I membrane proteins. Afaf is a vesicle factor derived from the early endosome trafficking pathway that is involved in the biogenesis of the acrosome on the maturing spermatozoon head.
Statistics
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PSSM-Id: 495021
Aligned: 8 rows
Threshold Bit Score: 261.348
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2LCV6         63 PANEKTGNYYKDIKQYVFTTPDSK-GTKTEVSVTAT---TDLKFTM-KDYKSSKATAS---------GEEDKRSEPSRKS 128  Norway rat
1_pfamImport    1 PYNDKNDHHFKEEKNYVFTTQTPT-GSQSEISVKAT---TAVDFSL-RNSRHVTAQIYetl----kvNEGENTKEPCRKN 71  
Q9D9V2         64 PANEKTGNYYKDIKQYVFTTPNIK-G--SEVSVTAT---TNLEFAVkKNYKASKPTAS---------GEEEKPSESSRKT 128  house mouse
XP_008248910  218 PANEKSGNYYRDIKQYVFTTHNPN-GSESEISVRAT---TDLRFAL-KNYKLGNASAEk--------PSEEKPSEPSHKN 284 
ELW70236      307 PADDNSHENFRDVKQYVFTTQNAN-GSESEISVRAT---TDLKFAL-KNYKMINKTTSekp----isEEEKSVPESSHKN 377 
Q9NQ60         53 PANEKNGNYYKDIKQYVFTTQNPN-GTESEISVRAT---TDLNFAL-KNDKTVNATTYeks----tiEEETTTSEPSHKN 123  human
2_pfamImport    1 PANEKSGNHYKDIKQYTFVTQGPN-GTGPEISLRAT---TDVNFIL-RNFce-------------asKDKTEDKEKKENE 62  
3_pfamImport    1 PANEKTGDHYKDIKQCKFITHHSSyGLSSHVLIRCTslkTINSFSL-----FLDKPNKatrydkpttEEEES-QETYHNS 74  
Q2LCV6        129 ST---------PNVPAFWTMLAKAINETAV-SMD---DKDLFYQAIPASDLNSTN----EDQLSELEEIKLKLMLGISLM 191  Norway rat
1_pfamImport   72 IQnfktettevPNEPAFWTMLAKVLNETVP-EEE---SRDQLFQAIPSSDLNATS----EDQGVEAQDNKLKLMLGISLL 143 
Q9D9V2        129 ST---------PNIPAFWTILSKAVNETAV-SMD---DKDQFFQPIPASDLNATN----EDKLSELEEIKLKLMLGISLM 191  house mouse
XP_008248910  285 IQrt------tPNLPEFWTMLAKALTQSTS-GFE---GND-LFKPIPGSDVNATN----QDKLSELQEIKLKLMLGIALM 349 
ELW70236      378 IQ---------------------TISETTK-SMD---DKDQLFQPIPSSDVNATNeeeeEEELSELDEIKYKLMLGISLM 432 
Q9NQ60        124 IQrs------tPNVPAFWTMLAKAINGTAV-VMD---DKDQLFHPIPESDVNATQ----GENQPDLEDLKIKIMLGISLM 189  human
2_pfamImport   63 KTept----kgQNEPEFWTMLEKALNATPP-REQrneEKDQLFNPIPSSDVNLES----KQEAGELEGIKQKLMLGISLM 133 
3_pfamImport   75 FQks------tPNVPAFWTMLAKALNGSAVyNMD---EKDQLFHLIPRSDLLMAN----DDKISELEELKIKLMLGISLM 141 
Q2LCV6        192 TLILLIPLLIFCFATLYKLRHlRDK-TCES-QYSVNPELATLSYFHPSEGSNQTVLTEESSFL 252  Norway rat
1_pfamImport  144 TLLLFTILLASSSALLYKLKT-SYNkQLER-QYSIHPELASLSYFQPAQGVSDSSFSRSAESS 204 
Q9D9V2        192 TLVLLIPLLIFCFATLYKLRHlRDK-SYES-QYSINPELATLSYFHPTEGVSDTSFSKSADSN 252  house mouse
XP_008248910  350 TLLLFVTLLAFCSATLYNLKQlSYK-SCES-QYSINPELATLSYFHPSEGVSDTSFSKSAESS 410 
ELW70236      433 TLILFATLLAFCSIMLYRMKQlSYK-SCQS-EYTINPELATLSYFHPSEGISDTSFSKSAESS 493 
Q9NQ60        190 TLLLFVVLLAFCSATLYKLRHlSYK-SCES-QYSVNPELATMSYFHPSEGVSDTSFSKSAESS 250  human
2_pfamImport  134 SLFLFLALLTLCCATLYKLRKlSSKsECDDgQYSVNPELAEMSYFHPSEGVSDTSFSKSAESS 196 
3_pfamImport  142 TLFLFLILLGLCCATLFKLKRmGQN-DYES-QYSINPELATMSYFHPSEGVSDTSFSKSAESS 202 
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