Conserved Protein Domain Family
LIME1
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pfam15332: LIME1 (This model is not part of the current CDD release)
Lck-interacting transmembrane adapter 1
LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localises to lipid rafts in T cells in response to TCR stimulation, and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2. LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation.
Links
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Statistics
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PSSM-Id: 521785
Aligned: 7 rows
Threshold Bit Score: 241.004
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001102084  27 LCTAC----HR--------KRAQRQQTGLQGSLMPVEVPLLRQAHLCSLSKSDTRLHELHRGQRSTIAPRPASMDLLHPR 94 
4_pfamImport   1 LCTAC----NRaddplaprKQSRRQLSRLQGSAMPAEVSLLRRPHHCSLSKSDTRLHELHRSRPCSRAPRPASMDLLCPQ 76 
XP_054530478  30 PEDAV----APrkrarrqrARLQGSATAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRD 105
3_pfamImport   1 LCTTCgssaPRpddalaprKRGQRRCARLQGSVMPAEAALLRQTQLYSLSKSDSRLHELHVGPQGCRAQRPVSMD-LHPH 79 
XP_021582099  27 LCTAC----HR--------TRVPRHRARLQGSMMPVQVQ-VRHQAAGAVPR-----------PTQQHPPRPASMDLLRPH 82 
1_pfamImport   1 PGVPC----PApl---------------aVGAVRSLPQSLLRRPHLCSLSKSDTRLHELHGGPRGSRALRPASMDFLRPQ 61 
2_pfamImport   1 LCAAC----HRpddplaprKQARRQPAGLQGTMMPAEMSLLRQPPLCILSKSDTRLHELHQGPLHRTAPRPASMDLLRLQ 76 

NP_001102084  95 WLELSRGSTRSqvpNSAFPPRQLPRAPpaapatpPSTSPEATYSNVGLAAIPRASLAASPVvwpgrqlt-----isctrl 169
4_pfamImport  77 WLEASRGMTRP---PAPFSHQELPLAA-------PSTGPEATYSNVGLATIPRARLAVRPV------------------- 127
XP_054530478 106 ITGPQAAPSAFphqELPRALPAAAATAgcagleaTYSNVGLAALPGVSLAASPVVAEYARV------------------- 166
3_pfamImport  80 WLEVSRDPRRLqaaPSAFPHQEQPQGPpa---atPSAGSLATYSNLALVAIPRAGLAASSV------------------- 137
XP_021582099  83 WLEVPRSSTRPqaaPSIFPPQQLPKASpvs--psPFIGPEDTYSNIGLAAIPRASLASSPVvwagtrltigcarpglgar 160
1_pfamImport  62 WLEESRGTIRP---PAAFSHRELPQA--------PSISPEATYSNVGLASIPRASLAANPVvwagarltsscarpgpevr 130
2_pfamImport  77 CLEVSRDTTRP---PAAFSHRDLPQTSpttaaaqPSTGPEATYSNVGLAAIPRASLAASPMv------------------ 135

NP_001102084 170 gpGAEYACIQKHKGTEQGCQESQQ-KAKVTPATQMDVLYSRVCKPKRRDPRPDTDQLNLQDGRTILALGNDVKYEAITLR 248
4_pfamImport 128 --VAEYACVQKFRGTDQGPQGLGQgKVEATPPTQVDILYSRVNKPKRRDPGPATDQPDPKGGGAILALGSDPAYEVLPLG 205
XP_054530478 167 --QKRKGTHRSPQEPQQGKTEVTPaAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALASDLAYQTLPLRALDVDSG 244
3_pfamImport 138 --ATEYSCVQKLKITQRAPQELQQaNAEVSPTAQVDILYSRVCKPKRRTA-PTTDPPDPKGRGAILVLESDLAYEVLPLW 214
XP_021582099 161 plVAEYSCIQKLKGTGQGPQELQQgTAERIPTAQVDILYSRVCKSESRDPGLIKNQPDFKGGGSILAPRNDMTCETLPLR 240
1_pfamImport 131 pvVAEYGCIQKLQGTGPGPQALEQrKAQVIPAAEVDILYSKVNKPKRRSPGPVIDQPDPKGRGAILVLGSDRAYEALPLR 210
2_pfamImport 136 --VAEYACIHKLKGTGRGPQGLDQgKVQGTPATQVDILYSRISKPKRRDAGSALGQPDPKSRVAILTRGRNLDYEALPLR 213

NP_001102084 249 GQDMKQGTLENVYESIKE 266
4_pfamImport 206 GLAMDKSLLENVYESIQE 223
XP_054530478 245 PLENVYESIRELGDPAGR 262
3_pfamImport 215 GRGMDHRPLENVYESIQE 232
XP_021582099 241 DLSMDSRPLENVYESIQE 258
1_pfamImport 211 GRGVDNSLLENVYESIQE 228
2_pfamImport 214 GLSTHSD-LENVYESIQE 230
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