Conserved Protein Domain Family
SIT

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pfam15330: SIT (This model is not part of the current CDD release)
SHP2-interacting transmembrane adaptor protein, SIT
SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.
Statistics
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PSSM-Id: 521783
Aligned: 28 rows
Threshold Bit Score: 66.6599
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004040982  164 VLLPLIFTILLLLSVAASLLAWRMMKRQQKAAGMSPEQ--------VLQ--PLegdlcYADLTLQLAGISPQKATTKLS- 232
10_pfamImport   1 WGVLAFLSLALLVSLSLNISHCMKKKQAKMHKDYKENNpsy--dgyDTEdyPV-----YGNLNQ---DILEECCYEQMKs 70 
XP_004175261    8 WGALAFLSLALLVSLTLNIVHYIKKKQAKMHKDYEESNpsy--dgyHTEddPV-----YGNLNQ---DILEECCYEQMKs 77 
NP_057472      12 WGLLALLGLALVISLIFNISHYVEKQRQDKMYSY-SSDhtrv-deyYIEdtPI-----YGNLDDMISEPMDENCYEQMKa 84 
2_pfamImport    1 WAILAFLGLALVVSLIFNISCYVEKQRQGITYRF-SDDyisredeyYIEdtPI-----YGNLDNVIPEPMDENCYEQMKa 74 
DAA33516       12 WAILAFLGLALTISLIFNIFHCVEKQRQEKICTY-SDDyfpredeyDLEdsPI-----YGNVDNVALEPVDENCYEQMKa 85 
7_pfamImport    1 WGLIALLGLALVISLIFNISHYVEKQRQEKLYRY-SDDyiprddeyYIEdtPI-----YGNLDNVVPEPTDENCYEQMKa 74 
Q3UU67         12 WGLLAFLGLALVISLIFNISHYVEKQRRDEIYRY-SDDyiprvdeyYVEdaPI-----YGNLENIIPEPLDENCYEQMKg 85  house mouse
XP_013007180   12 WGLLVLLGLALIILLIFNISHHVEKQRQDKMYRY-SDDyipradeyDIEdtPI-----YGNLDNVILDPIDEDCYEQMKa 85 
1_pfamImport    1 WGLLAFLGLALVISLIFNISHYVEKKRQDYMYRYSDDYiprv-dedYIDt-PI-----YGNLDNIIPEPIDENCYEQMKa 73 
XP_004040982  233 SAqadQVEVE--YVTMAPLPKEDISYASLTLGAEDQ 266
10_pfamImport  71 QPprpVNQLQ-------VEPANQMCYASLDHSAKGK 99 
XP_004175261   78 QPqrpVNQLQ-------VESANQMCYASLDHSVKRK 106
NP_057472      85 RPeksVNKMQeaTPSAQATNETQMCYASLDHSVKGK 120
2_pfamImport   75 RPersVNQLRaaPTPAQATNEAQMFYSSLEHSLEGK 110
DAA33516       86 RPdrsVNKLQd-aPPSQETA-VRVCYASLDHNNEGK 119
7_pfamImport   75 RPersVNKRQeaSIPAQAASDTQMCYASLNHSAKGK 110
Q3UU67         86 RPqrsASDPQevAAPAQVPAEAQMCYASLDHSVKGK 121 house mouse
XP_013007180   86 RPersVNNAQevASSTQVTAEAQMCYASLDHSFKGK 121
1_pfamImport   74 RPersINETQevPPSTQATTETQMFYASLDHSFKGK 109
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