Conserved Protein Domain Family
Tankyrase_bdg_C
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pfam15327: Tankyrase_bdg_C (This model is not part of the current CDD release)
Tankyrase binding protein C terminal domain
This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyzes poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.
Links
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Statistics
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PSSM-Id: 521781
Aligned: 14 rows
Threshold Bit Score: 147.637
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_039771070  217 DFSFID-RTSVLDSSALKTRVQLSKRSRRRAPTSHSCRGArt-pEAADGTPLPEENGSSWMFRDSTEEKSPa---PREDG 291 
XP_005999499  215 DFSFLD-QTSVLDSSALKTRAQLSKRRSRRAPTSKSIRKS----KLI----VVEEDDNSWMFKDSTESKPV----KQEDS 281 
XP_008109384 1507 DFIFLE-DTEVLDSTAYRDRANLGRKRGHRAPATRS------------GSALSESDRNSWMFKDSTEPQTAs-----AAS 1568
XP_023509828 1650 DFSFIE-DTEILDSAMYRSRANLGRKRGHRAPAIRP--G-------GTLGLSEAADSDARLFQDSTEPRTSr----VPSS 1715
6_pfamImport    1 ELSFPEpAASLLDCSAMKARAQLSRK-SRRSLPSRPARRCplpaGAERLGPLPED----WLYRDSTEHKPDp---PQEDS 72  
3_pfamImport    1 PLSFPDtPTILLDTSALRSRAHLGKKRAPRTRPSRAARQ------TEGEGGATDD----WLYTDSTEAKAEt---KDDDS 67  
2_pfamImport    1 YAPFPEsSTDLLNTSAQKSKAELGRKRNRTR-PSRSLH-----------GGFAHLESRDWKIDDSTDEKEVsskqRDLDS 68  
XP_069922141 1531 DFSFID-QTSVLDSSALKTRVQLSKRRRHRAPVSHALRRSrf-sQSESGCPLEEETDNMWMFKDSTEEKSP----RREES 1604
XP_016279026 1461 aprllpgppsedfsfmedtevldsamyrsranlgrkrghrapairpggtlglseadsdawlfqdsTEPRASr----VPSS 1536 gray short-ta...
XP_025011277  129 DFSFID-QTTILDSSALKNRVQLSKKRRHRAPLSHSLRRSrg-lEYENRFSLTEESGSTWMFKDSTEEKKPm---QQEDS 203  chicken

XP_039771070  292 DGGde--eaSPRSERV-PGGPAPRRPAFPGMDPSVLKAQLRKRQ--------------------EE-DVPAEATSS---- 343 
XP_005999499  282 DEEe----kPKKSERS-PAIQPQGLPMFPGMDPLALKAQLRKRP--------------------ES-DSPTEATA----- 330 
XP_008109384 1569 DEEvheeprIRKSRNS-PLTKGVKVPLFPGLSPSALKAKLRGRNrs----------------aeEV-DPQIESKEAp--- 1627
XP_023509828 1716 DEEvveepqNRRTRMS-LGTKGLKVNLFPGLSPSALKAKLRSRNrsaee-----------gepvES-RS-GQKESA---- 1777
6_pfamImport   73 DTEdpvntaR-RVERS-PAPQPQRVPLFPGMDPSALKAQLRKRT--------------------DS-DSQADTPSP---- 125 
3_pfamImport   68 DSGeptkgvD--ASAA-VSSQPQRIALFPGMDPSALKAQLRKRG--------------------DS-DNQIDGAAPs--- 120 
2_pfamImport   69 EEEqp----kPKIVCSpPPTTSQRVPMFPGLNPAALIAQLKKRTsggrtrggeeaeedkgrgvkES-RKEEVAPSP---- 139 
XP_069922141 1605 DEEee---kPPRAERT-PVSRPQRMPVFPGVDPAVLKAQLHKRP--------------------EVsDGPGETPSW---- 1656
XP_016279026 1537 DEEvaeepqSRRTRMS-LGTKGLKVNLFPGLSPSALKAKLRPRNrs----------------aeEG-EP-VESKSTpkes 1597 gray short-ta...
XP_025011277  204 DEEek----tQRSGRL-SSVQAQRLPIFPGMDHSVLKAQLRKRH--------------------ES-ESPGEPSS----- 252  chicken

XP_039771070  344 -KKWSKSPKSPFHAGNlGSRVLPPGGVKEDGSQDSSPQWLKELKSKK 389 
XP_005999499  331 -SQLSKSPKLSFPQGAaGCRVLPPTATKEEGSEEAHPQWLKDLKSKK 376 
XP_008109384 1628 -VQRSKSCKIANVSGK--PLVLPPKPEKSSGSETSSPNWLQVLKLKK 1671
XP_023509828 1778 -VQRSKSCKVPGL-GK--PLVLPPKPEKSSGTEGSSPNWLQALKLKK 1820
6_pfamImport  126 -TQLSRSPKSPFVPGT---RVRPPSGRKENGSEESSPQWLKELKSKK 168 
3_pfamImport  121 sSQLSRSPKSPFLPRA-A-RVLPPAGGKENG-EEDSPQWLKELKSKK 164 
2_pfamImport  140 -SQLPRSSRSAAHLAG-AARVLPPIGAADQG-PVSSPAWLKELKSKK 183 
XP_069922141 1657 -APQPKTPKTPFQPGVlGSRVLPSSVEKDDSSEEPSPQWLRELKSKK 1702
XP_016279026 1598 aVQRSKSCKVPGL-GK--PLALPPKPEKSSGSEGSSPTWLQALKLKK 1641 gray short-tailed opossum
XP_025011277  253 -AQPFKSPKPQL--GTpGSRILPSSVEKEERSEEKSPQWLKELKSKK 296  chicken
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