Conserved Protein Domain Family
TEX15
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pfam15326: TEX15 (This model is not part of the current CDD release)
Testis expressed sequence 15
TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.
Links
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Statistics
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PSSM-Id: 521780
Aligned: 7 rows
Threshold Bit Score: 403.887
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_051690027 1943 KKRkEKEGEIRSSNHPQSD--------YISQPSILEINHMPVSLAHSETSEVI-TlPTKPTLYTSDLIENHYSVGHMALL 2013
4_pfamImport    3 NKR-EQKGKIKISSDSQSDstlhsettNISKPDILGIHSMPVLHAPSETSKVT-T-CQKSTSYINELNEKHRSAKHTALI 79  
5_pfamImport    3 NKRkEEEG--RVSQDSQYDsslhsevaCDSKPGITGRNHMPHLRGQSEPPKVSpPpPKKSTSYMNEFKEKHCSSNNLAPT 80  
2_pfamImport    1 RTRrEKGGKVKATSDSQPDsiapseitCNFKPGVTEINHKPIPHAYPEVFEVT-AlQKKPTSYLNELKEKHGTANHAGFL 79  
3_pfamImport    3 NKR-KRKGKRKVSNDCQSG--------YISKPGILEIDHRPILHAHSETSEVT---IQKPTSYENELKENHCSVTQTALV 70  
F8VPN2       1574 KER-KEAGQIKVNNNSHSD--------CLSKPAIVETNHRPVLHGNPKVATLQ-----------KELKE-HRSPNYTSHV 1632 house mouse
Q9BXT5       1537 NKR-EKKGEIKVSKDSQSDltlhseiaYISKPGILGVNHTPILPAHSETCKVP-TlLKKPASYVSDFKEKHCSANHTALI 1614 human

XP_051690027 2014 VELSQILQRADEATSLQLLQEESMVCQNMLPLFVQAFEKKQECSLEQILITREVLVEQNLWDNCKHKLKPCAVDTLVELQ 2093
4_pfamImport   80 TKVSEILQRADEASSLQALQEETKVCQKCFPSFVEAFERKQKCSFEQIVISRESLVEKNMWNNCKHKLKPSAVDTFVELQ 159 
5_pfamImport   81 VKLTQILRRADETSSVQILQEESEVCQNILPLFVEAFERKQKCSFKQILISRDLLVEENLWSNCRHRLKPCAVDSLVELQ 160 
2_pfamImport   80 AQLSQILQRADEASSLQILQEETKVCQNILPSFVEAFERNQECSLEQVLISRDLLVQQNLWNNCKNKLKPCALDSLVELQ 159 
3_pfamImport   71 TELSQILQRADEASSLEILEKETKTCQNILPLFVEAFERKQECSLEQILISRELLVEQNLWKNCKYKLKPCAIDTLVELQ 150 
F8VPN2       1633 TELSQILQRADEAASLQILEEETKLCQNILPLFVQAFERQQECSIDQILISRKLLVEQNLWNNCRLKLKPCAVDTWVELQ 1712 house mouse
Q9BXT5       1615 ANLSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQ 1694 human

XP_051690027 2094 MIMETIQFIENKRRLLEGEVTFRSLLWYDDTLYGELLGRPRGYQQQSSFYPGFQGRLKYNAFCEMQNYHNQLIELC 2169
4_pfamImport  160 MMMETIQFIENKKRLLGGEPTFRSLLWYDETLYGELLVGPHGYQQQSNFYPAFQGRLKYNAFYELQTYHGQLIELF 235 
5_pfamImport  161 MMMETIQFIENKKRLLGGEPTFRSLLWYDETLYSELLGRPRGFQQQSNFYPAFQGRLKYDAFSELQSYHGQLIELF 236 
2_pfamImport  160 MMMETIQFIENKKRLLGDEPTFRSLLWYDETLYGELLGGPRGYQQQSNFYPAFQARLKYNAYCELQKYHDQLIEVL 235 
3_pfamImport  151 MVMETIQFIENKKRLLEGEPTFRSLLWYDETLYSELLGRPHGYQLQSSFYPAFQGRLKYNAFCELQNYHNQLIELF 226 
F8VPN2       1713 MAMETIQFIENKKRFLEGKPTFRSLLWYDESLYSELLRRPRGYQLQSNFYPGFQGRLKYNAFCELQNYHNQLVE-F 1787 house mouse
Q9BXT5       1695 MMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELL 1770 human
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