Conserved Protein Domain Family
Ashwin

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pfam15323: Ashwin (This model is not part of the current CDD release)
Developmental protein
This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern. It is also thought to be a crucial subunit in the tRNA splicing ligase complex. Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.
Statistics
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PSSM-Id: 521778
Aligned: 11 rows
Threshold Bit Score: 149.618
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005998074  19 SDFLLHPELLSRDFVLLTLQEKKIPIENEQVVDKDGLLDLYVQHVIPLPQRELPKSRWGRMMEKRREQQV--GLFVQTKS 96 
XP_006639314  22 TDLLLHPELLSQDFILLTLYEKKIPVEKEKEANRDHLTNLYLQHVIPLPQRDLPSSRWGKRMEKIRALQSpaNRSSQQQG 101
Q32LR5        21 VDLLLHPELLSQEFIQLMLQERNIAVSDPE--DRDRLTGLYLQHVIPLPQRELPRSRWGKRMEKSRPRLS----SSSTHS 94  zebrafish
2_pfamImport   1 VDLLLHPELLSHDFLQLILREKHVSTGERE--TRDRLTELYLRHVIPLPQRTLPDSRWGKRMEAIRGQRA--AAGHTSHS 76 
XP_003218816  21 DLLLLHPELLSQEFLLLTLEQRNVPVENELKVSKDSLTDLYVQHVIPLPQRELPKTRWGKRMEKQRGQQV--TKHDMKSF 98 
XP_028913106  12 AELLLHPELLSHDFLLLTLEQKNIVVENDTKSSKDGLTDLYVQHAIPLPQRDLPKSRWGKMMEKKREQKE--SKNESKSD 89 
1_pfamImport   1 THMLLHPELLSREFLLLTLQEKNIIGKEEIKTSKNDLIALYNRHALPLPQRQLPKSRWGKVVEEKREVKNe-LKNEQKSD 79 
XP_001364134  13 SEMLLHPELLSQEFLLLTLEQKNIVVEEEIKINKDDLTDFYVQHAIPLPQRELPKSRWGKMMEKKRGQNE--LKNEHKRN 90 
XP_002941199  16 SALLLHPELLSRDFLLLSLERRNIPVEDAFN-DKEKLTKIFVQHAMPLPQRDLPRNRWGRMMESKRGEKK---ITTVQKS 91 
XP_001630768  19 TVSYDHPEILERETLVDVLCTKGIDRQEINALDKVDLVKLFYKYAAPLPQRAQQLRR---------AKRKppKPSEHQPS 89 
Q9BVC5        13 SELLLHPELLSQEFLLLTLEQKNIAVETDVRVNKDSLTDLYVQHAIPLPQRDLPKNRWGKMMEKKREQHE--IKNETKRS 90  human
XP_005998074  97 LATD----GSRKRPL-------------------IVFDGSS---TST-SIKLKKNEN-----GTA----DRLK----PPP 136
XP_006639314 102 SACD----NSRKRPL-------------------IVFDGSS---TKT-SIKLKKTEA-----GSGa--vDRLK----PPP 143
Q32LR5        95 SSTD----SGRKRPL-------------------IVFDGSS---TSTgCVKLKKPDS-----SSApvttDRLK----PPV 139 zebrafish
2_pfamImport  77 SRND----HNRKRPP-------------------IVFDGSS---SHSgPLKVKKTEGtslstGTI----DRLK----PPP 122
XP_003218816  99 AAVE----NLRKRPL-------------------IVFDGSS---TST-SIKVRKTEN-----GTV----DGLK------L 136
XP_028913106  90 VAVG----GLRKRPL-------------------IVFDGSS---TST-SIKVKKTEN-----GAN----DRLK----PPP 129
1_pfamImport  80 VSVA----ASRKRPR-------------------IVFDGNS---TST-RIKVRRTEK-----AAN----DGLK----VNP 119
XP_001364134  91 MSVE----SLRKRPL-------------------IVFDGNS---TST-SIKVRKTEN-----GTN----DRLK----PPP 130
XP_002941199  92 AGTE----GVRKRPP-------------------IVFDGCS---TST-SIKVKRTEN-----GDAl---QRLN----PSP 132
XP_001630768  90 ASPKdiviGSRKRALtsegplrsklyrpddfskiIINKGPSkqkNKT-DIPMQTSKNdlspmSQDsskvTKLKrstpEPP 168
Q9BVC5        91 STVD----GLRKRPL-------------------IVFDGSS---TST-SIKVKKTEN-----GDN----DRLK----PPP 130 human
XP_005998074 137 SG-NTTNAIRRLSSLSSNSSSNSIIASPPRDTtvrkeetKPNRTPVNNNNNSSSTTVHLKSLPPSTSSSGTSIVKLKRAA 215
XP_006639314 144 SG-NLTNTIRRLSGPSANCSLDDSHRSSANHL-------SGKEEAQNNVATIHRSPTGNGKAPSSTLPTGGTTIKLKRVA 215
Q32LR5       140 SSvSLTNPIRKLSGASTNCSSSN----------------FSNRTPVSSSGAIPKSPSNHSNS---SVHSNNATSKLKRTS 200 zebrafish
2_pfamImport 123 AS-NLFNPVCKLSGNTP--SSSIHCTPDTANL---------QREANKKNA---------------SIHSSKQKTSLKNAL 175
XP_003218816 137 TAgSASAPCRRLSVSSDS-LACASVSTDSSDFki---gtSINESKQNN-IRINNNMASSQKSPPSLPVIGTTVVKLKRAA 211
XP_028913106 130 SThTTSHPLRKLSHPS---SPSVSPSVLPTDVkv----pTPNGSEQNHDVGTGRSSLANVKSPPSSPVGSPAVVKLKRAA 202
1_pfamImport 120 ------------PNDTKQ-SP----------------------------VLMDSSTVANVKSQPLSHVEETSVVKLKRIV 158
XP_001364134 131 SVgVTNNTFRKLPHSNT--SSLILPSTLPTDIkv----eSNNDTKQNHVLMTSRSTLANVKSPPLSPVGGTTVVKLKRTA 204
XP_002941199 133 ----------KESTNSTQNSSPALQLGFTTPNkeakgasAANHGQHDSSPVTDTTLI-SPKSAKLQQPIIVSAVKLKRTA 201
XP_001630768 169 KSkPVKLNRRSFTNHPSDGNK--------------------------------------------TTHAGTITQQSKHVE 204
Q9BVC5       131 QAsFTSNAFRKLSNSSSSVSPLILSSNLPVNNkt---ehNNNDAKQNHDLTHRKSPSGPVKSPPLSPV-GTTPVKLKRAA 206 human
XP_005998074 216 PKG-ETE-MGDLKPTEAKKKIQHVT--WP 240
XP_006639314 216 PKEgESEaTGEQKSPEPKKKIQHVT--WP 242
Q32LR5       201 PSKgEPDtAKDIKSPETKKKIQHIT--WP 227 zebrafish
2_pfamImport 176 LMLhLPSlQGSLTSPEVKKKIQHVT--WP 202
XP_003218816 212 PKE-EIDaSNGLKPSDSKKKIQHVT--WP 237
XP_028913106 203 PKE-EVEsVNDLKPTEAKRKIQHVT--WP 228
1_pfamImport 159 PRE-DAKsVNEFKSSGTKKKIQRIT--WP 184
XP_001364134 205 PKE-EAEsVSDCKPTEAKRKIQHVT--WP 230
XP_002941199 202 PKD-ESDvANDAKPTEAKKKIQHVT--WP 227
XP_001630768 205 VCKsDSDsMDE-DIVEVKTQFQKVAvkWP 232
Q9BVC5       207 PKE-EAEaMNNLKPPQAKRKIQHVT--WP 232 human
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