Conserved Protein Domain Family
RHINO
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pfam15319: RHINO 
RAD9, RAD1, HUS1-interacting nuclear orphan protein
RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.
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Statistics
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PSSM-Id: 495004
Aligned: 17 rows
Threshold Bit Score: 230.366
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_010715565   1 MPP--KKKRTHKTRKAELVFLERPWEGPIHCCET-PLYV-AENPVCVSTKPVDQNTSATWVCPQFETTKSLVLRVCQ--K 74 
XP_002191226   1 MPP--KKKCTHKARKAELIFLEKPRAGPIHCYEA-PLHL-AENPRRVPTKPVDLNTSAAWVCPQFDATKSVVLKACQ--K 74 
NP_001314963   1 MPRtsHKKRLLNPLKSQLLFKEAPINGPKHEYGA-QLRS-AIHPRSFISEK-QQRGDAPWVSPQFNSHATTRVSRGGrgK 77 
XP_028910046   1 MPP--GKKSRRPIPRAQLLFREAPLEGPKHPYGS-PQPT-DTRPRPVPTKPIDRKTATSWVIPQFEGSTGGRRPARQ--- 73 
XP_007503833   1 MPP--RKKCKGQPRKSQLVFREGPLDGPMHPYGS-PQLA-AALPRHAPIKRIDHKTITSWVSPQFKNTVEAWLPVYP--K 74 
EHA99825       1 MPP--KKGRGQPSHKAQLLFHQQPLEGPKHHCGSvKQRLtRTRTRQGPGKPID-GAIASWVSPQFDTTVESFFPGHQ--- 74 
XP_005000734   1 MPP--KKRR---SNKAQLLFHQQPLEGPKHHCESvRQR--ATHTVQVPSKPTD-QAFASWVSPQFDTTVDSLFPARR--- 69 
XP_006172108   1 MPP--RKKRRQCSQKAQLLFHQPPLEGPKHHCAS-PRRP-VTHTRQVPSKPIDRSTVTSWVLPQFDTTAESWVPAHR--- 73 
XP_006096144   1 MPP--RKKRRQTSQKAQLLFHQQPLEGPKHHYRS-PQLP-ITHTRQVPSKPIDHNTITSWVSPQFDTTAESWFLANRkgK 76 
3_pfamImport   1 MPP--RKRRRPPSRKPQLLFHQRPLEGPKHRCGS-PQLP-ITHTRQVPSKPIDHSTITSWVSPQFDTTAESWLPDNQ--K 74 

XP_010715565  75 KQHgshklQNQdvnygllhAETA-----CRRSVACKFPPLIFENSEVCSVHSTDTLSha---gkNTQHSHSQFKKGIGSK 146
XP_002191226  75 KHRgpqkpYNQdanhssfhAGGA-----CQGAVACRFPPLTFENPEGHAVPLLDDPNcl---rkNAQCSPIQPRKGTAAN 146
NP_001314963  78 RNHqvatrITN--------KASAlclpqTRKASVSRFTPLSFQATTIQ-GLENLRHPqtkkntfVSSDKHQKELQETPRR 148
XP_028910046  74 RPP-----RDP--------VGNS-----GRKPHPCKFLPLAFAGLQGPCREQAPTSPpavkrpgRASQSPTRARVRAGRQ 135
XP_007503833  75 QQQmpynlRNL--------AKGS-----SRKVTKNRFPPLSFESSESSSSEATLDSL-------SVTKCPMQHPKDTTQR 134
EHA99825      75 KHH-----QDR--------ARLS-----SRKST-CKFPHLVFENPLFSSSPEIPEIP-------SVKECRSQSEKDISRQ 128
XP_005000734  70 KHR-----RDR--------ARLS-----SRKST-CKFPHLSFESSKSSSRPEIPAIP-------LVRECLSRSERDVSRQ 123
XP_006172108  74 KQH-----RDQ--------ARRS-----CRKSSSSRFPHLAFESPQSACSSETPRVP-------LIRGHPNPSVKDASRR 128
XP_006096144  77 QHH-----RDQ--------PRHS-----NRKSATSKFPHLTFENPQSSSSSATLGGP-------LIQESPDHSVKDISGR 131
3_pfamImport  75 RRH-----RDQ--------ARRS-----SRKSASSKFPHLAFESPPSSASSATLGIP-------LIRDHPSQPEKDISRR 129

XP_010715565 147 ANIQVNGSENCSE------------------------------TPlsisqPvgPDVFSPLGTGMPQLPslrnCTCSSALP 196
XP_002191226 147 ANIQVKSPENCGEl-----------------------------AV-----E--QDVLSPSDAEAAQVPsprnGRCSSTLS 190
NP_001314963 149 SKCA----RKCTEkrmltrvksatskytevsksltfhnngkglTNaliqtPntSLVPDPPHVETPEVP-----NCSSISP 219
XP_028910046 136 PLVPMFSPQSCGHl-----------------------------SGrepasP--GFAFLPPDIQTPEMP-------SGRGP 177
XP_007503833 135 PLVPVFSPQSCGEl-----------------------------SPhdlqtP--GYMFIPPDIQTPEQSp---VRNSGQIP 180
EHA99825     129 PLVPMFSPQTCGEl-----------------------------SAhalqsL--PCVFAAPDIQTPGPS-----VREDSSP 172
XP_005000734 124 PLVPLLSPQSCEEp-----------------------------SAhvlqsS--LCVFPAPDIQTPGPS-----EREDPSP 167
XP_006172108 129 PLVPMLSPQSCGEl-----------------------------SEqplpsF--PCLLIPPDIQTPGSSp---ATKST--- 171
XP_006096144 132 PIVPMLSPPSYGEm-----------------------------SAhelqnL--PYMFIAPDIQTPESS----SVKQVGLP 176
3_pfamImport 130 PLVPLLSPQSCGEl-----------------------------SAqelhsF--PYVLLPPDIQTPESL-----MKGGLIP 173

XP_010715565 197 QiSSHA-----ELvsSVLHCGREQLAGTLVMDTPEREYGIKVTWRRRPHLLKYLRDRGKLSTADILV 258
XP_002191226 191 P-SSHAwhpeeELpfGTDPCGRGEAAAVLVTDTPEHEYGVKVTWRRRPHVMRYLREQGKLSAADILV 256
NP_001314963 220 SnVQQLifp----psQAKTPPRAENTSVLVEDTPEKDYGLRVTWRRRKGLMKLLIDKGQL------L 276
XP_028910046 178 EdPEPSprpfgGLlsHSSPPEDSGPGPTLVLDTPEESYGLKVTWRKRRHLLAYLRERGRLSQSQFLV 244
XP_007503833 181 TaHRQHmkrscPL--LMDPPKSPDPGPVLVADTPEENYGLKVTWRRRYELLTYLRKRGKLSMSQILV 245
EHA99825     173 PeQRENslpvcV---HTCAPHSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFEYLRERGKLSRSQFLV 236
XP_005000734 168 PgQGENsppvcV---YSPTPDTPDPGPVLVKDTPEEKYGVKVTWRRRRHLLVFLKERGKLSRSQFLV 231
XP_006172108 172 PdQRENrlpscSL--HIRAPSSPEPGPVLVKDTPEEKYGLKVTWRRRQHLLTYLRERGRLSRSQFIV 236
XP_006096144 177 PdQKENslpscSL--HTSTPESPEPGPVLVKDTPEEKYGVKVTWRRRRHLFTYLRERGKLSKSQFLV 241
3_pfamImport 174 SeQRENsppscSL--PTSVPESPEPGPVLVEDTPEEKYGLKVTWRRRRHLFTYLRERGKLSRNQFLV 238
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