Conserved Protein Domain Family
FRG2

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pfam15315: FRG2 
Facioscapulohumeral muscular dystrophy candidate 2
This family of proteins is found in eukaryotes. The family is localised close to the D4Z4 repeats on chromosome 4 and 10 that are associated with the autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). FRG2 are transcriptionally upregulated in FSHD myoblast cultures suggesting involvement in the pathogenesis of FSHD.
Statistics
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PSSM-Id: 495000
Aligned: 5 rows
Threshold Bit Score: 234.009
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELW69108      23 GSEPElsPDEeKSSQESELTARHS-ISQSESESSSDEGRSRKRKASSGD-SCQAQPGNyEPGDEDGETLEKKRKPSvgLD 100
ELK06695      60 GLEPE--TDKeENSKETKFKGRKScIAPSEAERCSNRESSRRRKSRSRD-SPRATAGA-SLGEERSVTLEKKTRKV--PD 133
Q64ET8        60 GSEPN--PNK-ENSEETKLKAGNS-TAGSEPESSSYRENCRKRKMSSKD-SCQDTAGN-CPEKECSLSLNKKSRS---ST 130 human
2_pfamImport   1 GSKPS--PHE-EKSQERKLRGRSS-VARAESESSCDGVSSRKRTISSEDsSHTGT-GS-CV-QELSVTLQKKAKP---SD 70 
1_pfamImport   1 GSEPE--TDE-ENSKETELKRHSS-SSGSELEGCSSWEGSRKRKISSSDsTCDGA-GA-SPADEGSVTPGKKKRRA--SD 72 
ELW69108     101 GRSSSEGQPTRGAHSSGPLRAGSGRPNQPRSRSPGGRPPPLRKSLVTSLRTLSEAIYQDMAQVWAQQAHTPLTEEQLAEL 180
ELK06695     134 AGHSSDCETTPDVCPRRAQRRRTGCSKRPRSRSPGVQPPPLRKCLVTSLRAMSEAIYQNMVRVQNQRVPSQLSGEQLSML 213
Q64ET8       131 AVHNSEIQETCDAHHRGHSRACTGHSKRHRSRALGVQTPSIRKSLVTSVRAMSEAVYQDLAQVWAQQIHSPLTCEQLTLL 210 human
2_pfamImport  71 DGNDRGIQEAHAEPRRANSRARSGHKRRRRSRSPADHPPPLRKSLVTSLRSLSEAIYEDLARVQAQQAQIPLTQEQLFAL 150
1_pfamImport  73 HGRSSESQGTAPARPGRRWARGSGRSRRGRHSPRGDRPPPLRKALVTTLRALSEAIYQDVAQVCELQKHSPLTWEEQFGL 152
ELW69108     181 AQLRGPLHAAVQTFYAMARQAA-CTFPAEGWF 211
ELK06695     214 SQIRERLCAQVQTVYTMATQAA-YVFPAETWL 244
Q64ET8       211 TRLRGPLCAQVQTLYSMATQAA-YVFPAESWL 241 human
2_pfamImport 151 AQLRGPLCSAMQSSYALASQAGsLGLPCPGLA 182
1_pfamImport 153 GQLWGPLYSALQTVYTMANQAA-YAFPAESWL 183
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