Conserved Protein Domain Family
PRAP
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pfam15314: PRAP 
Proline-rich acidic protein 1, pregnancy-specific uterine
PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homologue. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression.
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Statistics
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PSSM-Id: 494999
Aligned: 11 rows
Threshold Bit Score: 63.2559
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_019664964  98 PEPDRDDLYHPPPgegeEAQEEAGLWSRALSPPRGLQGPEEDRDHIYH 145
3_pfamImport   1 PEPDHDSLYHSLT----EDQGGTRPWLRALPSHQVLRGPEEDRDHIYH 44 
XP_005225772  96 PEPDWDSLFHDGPe---EVLEEARPWARVLPPRQVLHGPEEDRDHIYH 140
1_pfamImport   1 PEPDRDHLYHSWPq---EAQEEARPWARALPPRQVLQGPEEDRDHIYH 45 
2_pfamImport   1 PEPDLDSLYHPASq---EIQVKEEPLLRAMLSRQVLRGPEKDLDHIYH 45 
EHB00969      93 PETDHDSLYHPESe---EIQVEEEPFSWAVLSRQVLQGPEEDLDHIYH 137
Q9ES75       100 PELDLDSIYHPMSe---DVQNEEVPQSRPILYRQVLHGPEEDLDHISH 144 Norway rat
4_pfamImport   1 PELDLDSLYHPPVe---EVQGKERPWSPVLLPRQVLEGPEEDLDHIYH 45 
ELW67312     250 PEPDHDHLYHPLPe---EAQGEERHWLWAMLFHQVLQGPEKDQDHIYH 294
XP_008977210 105 PEPDYDGLYHPSPe---EDQGAEEPQLWVVPNRQVLQGPEKDQDHIYH 149
Q96NZ9       105 PEPDHDSLYHPPPe---EDQGEERPRLWVMPNHQVLLGPEEDQDHIYH 149 human
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