Conserved Protein Domain Family
HEXIM
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pfam15313: HEXIM (This model is not part of the current CDD release)
Hexamethylene bis-acetamide-inducible protein
HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Links
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Statistics
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PSSM-Id: 521773
Aligned: 18 rows
Threshold Bit Score: 108.75
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005796724 160 WKPYNKLSWEEKKALEERETVRASRMREEMFAKG-LPVAPYNTTQFLMDEHDreepdlnt------------eagvrrls 226
XP_002116554  85 FSNYQNLSCQEKAELEEMAAEEATQLYNQRIQSG-LPVTPFNTTQFIMDDYE---------------------------- 135
XP_019850119  80 WKPYSKMSLEERKQVDEWEEKHVAIREAEINARSkRPVAPFNSTQFLIDDRCedq----------------------yrr 137
EEC12396      88 WKPYYKLSWEERRELEERESRRANRLRQQMFAHG-QPVAPYNTTQFLMEDHCvqepdfes------------rnghhrhr 154
OWR53811       1 ------MSWQERRKVDN--TKRNNRFRKIVLTKT-Q--APFNNNQFLMEIHKpepennfl-------------lyrtpsa 56 
1_pfamImport   1 LKPYSKQQLSYQQQLRYRSRGRLAKTGR-------QPPALYNTTQFLMDDHSdlpdldqklseaasselpatfqkpsaps 73 
EGI69951      99 LKPYSKQ-LSYQQQLRSKYIGRIAKTSR-------QPPALYNTTQFLMADHSdlpdleqklseaaslevpalfpkpwaps 170
ELK14195      54 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKG-QPVAPYNTTQFLMNDRDpeepdldv-------------phgashp 119
XP_035127650 102 WRPYLELSWAEKQQRDERQSQRASRVREQMFAKG-QPVAPCNTTQFLMNDQDpeelnldl-------------ppgvshp 167
EDO36416      27 DKEIFDFSVVPVKR-----------------AKG-RTAAPENTTQFLMDDHEkfepfvl--------------sspslsp 74 

XP_005796724 227 GVSGRMEDTGSEEDLFDNEEEEDddgsggggsdgigrpGNAGGEY-LQRDFSETYEMYHVESLQNMTKQELVQEYLELEK 305
XP_002116554 136 KARARSVNDNSDDLLDEIQRMED---------------KSENGNYsGEDEFTAHLEEIRFDKYDRMSKGELVRYCYQLDK 200
XP_019850119 138 PSRTLSFDSSSGDDVHYDLSDED------------------QEAF-LEADFNQVYLQLKLNRLEGMSKQDLISQCCNLED 198
EEC12396     155 EDSVNS--VDSSDEFYSSPEDED--------------------DF-LQKQFSEAYDDVHAERLSSMSKAELVQEYLLLED 211
OWR53811      57 RTRDSSFSIDSEDNYFHSLPEDE-------------------EEY-LTKEFSSVYEDAQCERLSNMSKNELIQEYLLLEA 116
1_pfamImport  74 RTRDSSFSVDSDEDYFYSSPEDE-------------------EEF-LTKEFSTAYEDLHAERLSTLSKSELIQEYLQLEA 133
EGI69951     171 RTRDSSFSVDSDEDYFYSSPEDE-------------------EEF-LTKEFSTAYEAVHEERLSTLTKTELIQEYRHLEA 230
ELK14195     120 GSSGESEAgds------------------------drlGHGHGEF-QQRDFSEAYERYHTERLQGRSKQELVQDYLDLER 174
XP_035127650 168 GSSGESEAgds------------------------dgrGQVHGEF-QQRDFSEAYERFRTESLHGRSKQELVRDYLELEK 222
EDO36416      75 NSSGCEFSSSSVRGSPVCERDLQsvtelv---------gnfdelY-FEKDFNDVYDSIHAETLLGLSKQELIYKYMELEK 144

XP_005796724 306 CMSRL 310
XP_002116554 201 KIQQL 205
XP_019850119 199 KVSVI 203
EEC12396     212 RVEDL 216
OWR53811     117 KYDNL 121
1_pfamImport 134 KVDLL 138
EGI69951     231 KMDSL 235
ELK14195     175 RLSQA 179
XP_035127650 223 RLSQA 227
EDO36416     145 KEENL 149
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