Conserved Protein Domain Family
JSRP
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pfam15312: JSRP (This model is not part of the current CDD release)
Junctional sarcoplasmic reticulum protein
JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalises with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.
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Statistics
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PSSM-Id: 521772
Aligned: 10 rows
Threshold Bit Score: 56.6917
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHB06586     112 EELPWGDVTLNKCLVLASLVALLGSAFQLCR--DAVTAEEAvpa------pwiPPISAPKALASPA 169
2_pfamImport   1 EELPWGDLTLNKCLVLASLVALLGSAFQLCR--DVVVGVADapapv--pepwvPPRSAPKKPASPS 62 
5_pfamImport   1 TEKPWENVTLNRCLVVAITILVLASGLQRLH--ETLRSQRAveeeedvglrvrRSGALRHRGQEAE 64 
NP_001103061 113 DELPWGDLTLNKCLVLASLLALLGSAFQLCR--DAVAGEAVaapq-----qwvPPSSPTKKPASPT 171
3_pfamImport   1 EELPWGDLSLNKCLVLVSLVALLGSAFQLCRvpDAVTGKVDvpapa--pepwvPPSSAQK-PREPL 63 
XP_005332055 118 EELPWGDVTLNKCLVLASLVALLGSAFQLCH--DAMIGERTapapa--pepwvPRSSPHTEPVPSL 179
4_pfamImport   1 EELPWGEVTLNKCLVLASLVALLGSAFQLCH--DTVVGEVAvpppa--pelwaPPSLVRKESTSLP 62 
XP_040027116  80 IETPWENVTLNRCLFVAISILVVTSGFQKLH--ESLRGQRAaeeedv-gltvrRTGRLRHSRPPPE 142
XP_021324043  79 MERPWEGVTLNRCLIVAITILLLSSGLQRIH--DAVRGRKEdseelt-vltdrHT-LLRRGKITPQ 140 zebrafish
Q2YDF7       121 DELPWGDLTLNKCLVLASLVALLGSAFQLCR--EAVARDVEapapv--peswaSSSSSPKGPASTL 182 domestic cattle
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