Conserved Protein Domain Family
AKAP2_C

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pfam15304: AKAP2_C (This model is not part of the current CDD release)
A-kinase anchor protein 2 C-terminus
This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.
Statistics
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PSSM-Id: 521766
Aligned: 12 rows
Threshold Bit Score: 85.9698
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003788879 286 IPARPLLTTANLT---AAP-RRNRGR---P-SLYVQRDMVQGTQREEDHRREGLQvslrvsqaSTPYWVPEEPQPGCQRA 357 
XP_034513113 296 IATRPLLTKVSLV---STP-RRDRGR---P-SLYVQRDLEQGTRREEDHRREGLQ--------AAPDGLSPGPQSGLRRA 359 
EHB14448      37 LRVRPLLHLPGPSp--ALPrAVERAR---A-GAQMQREIEREAHREAALLHL---------------------------- 82  
NP_001100631  37 LRVRPVLSRPGSGi--PLPrALERAR---A-GAKMQRDIEREAHRQAALASP---------------------------- 82  
KAI2589215   179 LRVRPVLNLPGPGp--ALPrALERAR---A-GAQMQRDIEREAHRQAALARP---------------------------- 224 
XP_002428860 187 FKIPKNLNKKDAV---ENDtRDVQHR---IaTNRIQQEIEEANERENELRTE---------------------------- 232 
EEC10192     694 VLPSSICKTVKTGsvpRGPpPLGSTQkilA-TSRIQQEIEEQTQREMALRESGHIqtisqertDSRVTRIGSDGSTSPTA 772 
XP_006101881 293 IPTRPLLTKLSLT---AAP-RRERGR---P-SLYVQRDMAQETQREEDHRREGLQgg----wvSKPDCLSGGPQPGLRRA 360 
Q3B7P0       341 IPARLLLSKVSLA---AAP-RRDRGR---P-SLYVQRDIAQESQREEDHRREGLQvg----raSTPDWSSEGPQPRLRRV 408  cattle
EHB16930     298 ILTRPLLTKVNLA---EVP-RRDRGR---P-SLYVQRDMVQETQRVEDHRRKGLQas----gaSTPDWVSEDPQPAFGRK 365 
XP_035311901 289 IPSRPLLNKVSLT---ELPsRRERGR---P-SLYVQRDMVQETQREEDHRREGLQvg----raATPDWTSQDPQPGLQRS 357 
Q8IVT2       325 IPTRPLLTKLSLI---TAP-RRERGR---P-SLYVQRDIVQETQREEDHRREGLHvg----raSTPDWVSEGPQPGLRRA 392  human
XP_003788879 358 YSSDATLSPVPDARAADPAPEVRKVNRIPPEAYQPYLNPGNPPLELSVLGrAYSKPGNVSKEEVKAPASPKAKGSWRHLS 437 
XP_034513113 360 LSSDSILDLASDAGAADPAPEVRKVNRIPADAYQPYLRPGNPRQEFPAFH-AHGKPRGLSTDGAKAAGSPRAAGSQRPLL 438 
EHB14448      83 --------TGSEPCVRQPPPPLGELRRFFEAAAG---------------GdSAGNDAG-----------------QQRLP 122 
NP_001100631  83 --------AVPEPSARPRPQPLDELKRFFEAA--------------------AEDGAS-----------------LQRQP 117 
KAI2589215   225 --------AVPEPRARSPPQPLGELKRFFEAAAGSGSSA------------GAGDGAG-----------------PQRLP 267 
XP_002428860 233 --------------GKILTTSEERVTRFTQLAEFAILEN-------------RHKDSRMKRSLSVSTLQVSDEGNNKNKI 285 
EEC10192     773 PVNSTTTSKRNSFDASLPNVEIYEKTPSPTNKLSP----SSPPLSTTAVKaTNGHAAKATNGTTRGVSMQKFLASRGKEL 848 
XP_006101881 361 LSSDSILGLAPDARAADPSPELRRVNRIPPDAYQPYLSPGAPQPRLPAFH-ARGKPGGLAADEAKAVA--KATGSQRHLS 437 
Q3B7P0       409 HSSDSILSPTPDAHAASLAPEVRKVSRIPPDAYQPYLSPGTPPGESPASH-AYCRPSNLSADEARPVGSPKAAGSQRHPS 487  cattle
EHB16930     366 TNSDPILDPMPDAGAADPAPETRKVNRIPPDAYQPYLGRGTPQPEFSPCW-GYRKPSG-------PPASPKSTRSQRLLS 437 
XP_035311901 358 LSSDCILS--PDARATDPAPETRKVNRIPPDAYQPYLGPGTPKLEFSAFG-VYSKPNGVSTEDTKAMEFQKAAGSPRHVS 434 
Q8IVT2       393 LSSDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFG-AFGKPSSLSTAEAKAATSPKATMSPRHLS 471  human
XP_003788879 438 ESTGKPLNT-----KQECPkPPQ---EPLQANRGVVRWEYFRLRPLRFRV-----PDMSQQAEALHFWGWDVP----GGP 500 
XP_034513113 439 ESSGKPAGTk----PEYSR-PPQ---GRPQAHGGVIRWEYFHLSPLRFRV-----PDVPPQAEGPRVRGWEVG----GTP 501 
EHB14448     123 EAEARGRSGv----QVRCPvLGR---APPP-------------------------------------------------- 145 
NP_001100631 118 EAGGRLHPAl----QDGCPvLGQ---LPPL-------------------------------------------------- 140 
KAI2589215   268 EPGGRPRSAv----QGGCRvLGS---APPP-------------------------------------------------- 290 
XP_002428860 286 NSAIKTPSSs----SSSSLlSNRrryAPNPAQKGIMQRFIATKGKIPFGSvnsesHIMGNDKNIRRGPIGRSItgidSSA 361 
EEC10192     849 VFTTPPQNGgfaekSAGFEyREL---KPPQLQKGVV-----------------------------------------SGD 884 
XP_006101881 438 ESSRKPSGTk----QESWK-PSG---APPPANRGVVRWEYFRLRPLRFGV-----PDVPQKAETPRTWGWEVA----GAP 500 
Q3B7P0       488 ESSAKPSGLk----QE----PPR---GPLHASRGVLRQEYFHLRPLRFRV-----PDEPERAEATRVWGWEVA----GAP 547  cattle
EHB16930     438 ESSGKPLSTk----------FPL---GDLQASQTMVPREYFRLRPLQFRV-----PDVQHQAETPHVWGWEVA----GAP 495 
XP_035311901 435 EYSGSSPSSk----QARSK-PPE---KPQHGSVGIVQLENFHLRPLRFSV-----PDVPQQAETSHTWGWEEA----GGP 497 
Q8IVT2       472 ESSGKPLSTk----QEASK-PPR---GCPQANRGVVRWEYFRLRPLRFRA-----PDEPQQAQVPHVWGWEVA----GAP 534  human
XP_003788879 501 ALRLQRSQSSDLLEREVesvlrrerevAEERRNALfpEVFSPTPde-sCGQDSRSS-SQASGIMGSYSVSESPL--FTPI 576 
XP_034513113 502 GSRPQRSQPSELLEREV----------AEERRNALlqEVFSPPPeengGERGSRGS-SAASGIMGTNSVSESYF--FSPI 568 
EHB14448     146 -------LALSLLEQEVrqvrereqelQRQRC-----SVYGTTE-----FKEPAPS-LTASRGDGKLAVT------WPPR 201 
NP_001100631 141 -------VAPSLLEQEVlrvrererelQLQRR-----SIYGAAE-----DREPAPS-LTQSRGDGKLAVT------WPPR 196 
KAI2589215   291 -------FTPSLLEQEVravrereqelQRQRR-----SVYGTAE-----FKEPTPS-LTASRGDGKLVVI------WPPR 346 
XP_002428860 362 LIRKGYVPAGEKIQEELkemekreeelRLQRAH----NPVGPAS----FFHRSQPNlLNISDEEGGDDDDDGELhsWTSH 433 
EEC10192     885 ALRKGLVTAETKIQEEMrvmkereeelRRQRIRLL---------------GQSQPN-LSLLESCVDMDSVDGHQ--LQRV 946 
XP_006101881 501 PLRLQRSQSSELLEREVesvlrreqevAEERRNALfpEVFSPql---dCDPDSRSS-SRASGTTGSYSVSESHF--FTPI 574 
Q3B7P0       548 ALRLQKSQSSELLEREVenvlrreremAEERRSALypEVFSDe----cCDHDSRSS-SRKSSITGSYSVSESHY--FTPI 620  cattle
EHB16930     496 ALRLKRSQSSDLLEREVedvlrrerevEEQRRSAFfpEVFSPTPedegCKQDSRSS-SRASGITGSYSVSESSI--FTPI 572 
XP_035311901 498 VLKLHRSQSSDLLEREMenvlrrerevAEERRNAFfpEVFSPVQd--qDEQDSRSS-SRASGITGSYSVSESPL--FTPI 572 
Q8IVT2       535 ALRLQKSQSSDLLEREResvlrreqevAEERRNALfpEVFSPTPde-nSDQNSRSS-SQASGITGSYSVSESPF--FSPI 610  human
XP_003788879 577 QLHSGLVWMAGDPVDRAPVQrIKKEQWYAGINPSDGINseileATRVTRHKNAMAERWESRIYA 640 
XP_034513113 569 HLHSRLVWTAEAPAESAPGQ-RKKESRYASINSLDHIDsevleATRVTHHKNAMARRWEAGIYT 631 
EHB14448     202 RKAP------------------------------------------------------DSGLEQ 211 
NP_001100631 197 RQAS------------------------------------------------------ENGLEK 206 
KAI2589215   347 RKVS------------------------------------------------------ENGLEQ 356 
XP_002428860 434 KQHK---------KPSLRLShSVSNPNLLDDDCLERVN------IRMPNKRFSLLQQWEDRIQS 482 
EEC10192     947 GSNPNLLESHQPSSPEGSGS-----------------------GSAAPRRRSALIAQWEQRIQS 987 
XP_006101881 575 RLHSGLVWTAEAPAEATPGQrKKKEQWYAGINPLDHVNsevleATRVTRHKNAMAERWEAGVYA 638 
Q3B7P0       621 HLHSDLVWTVEAPAKDALQQkKKKEQWYAGINPLDDVNseileATRVTRHRNAMAERWEAGIYA 684  cattle
EHB16930     573 HLHSGLVWTVEDPTDGAS-GhRKKGQWYAGINPSDGINleilgATRVTHHKNAMARRWEAGIYT 635 
XP_035311901 573 QLHSGLVWKVQAPNDGASGQrTKRETRYAGIKPSDRVNsevlgATRVTRHRNILAERWEAGIYA 636 
Q8IVT2       611 HLHSNVAWTVEDPVDSAPPGqRKKEQWYAGINPSDGINsevleAIRVTRHKNAMAERWESRIYA 674  human
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