Conserved Protein Domain Family
Syntaphilin

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pfam15290: Syntaphilin (This model is not part of the current CDD release)
Golgi-localised syntaxin-1-binding clamp
Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.
Statistics
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PSSM-Id: 521754
Aligned: 18 rows
Threshold Bit Score: 414.128
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011471585  58 PPGSPTANRDAdlyaphkTPPRAaLSTTNSSSCNSSPTS-RRVSLGRYHSCGENHGIRPPNPEQYLTPLQQKEVAIRHLK 136
XP_028918807 250 NQMSPVNAHPN-------YGPSS-PSSSNSGSYKGSDSSpVLRRAGRYASCGESHGVKPPNPEQYLTPLQQKEVTVRHLK 321
XP_006921737  62 RTSPPVSVRDA-------YGTSSlSSSSNSGSCKGSDSSpTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLK 134
XP_003226156  16 RPSPPVSMRDT-------YGTSSlSSSSNSGSCKGSDSSpTPRRPVKYLLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLR 88 
XP_069035573  47 RPASQVSIRDA-------YGTSSlSSSSNSGSCKGSDGSpTPRRHVKYASCTDNHGIKPPTPEQYLTPLQQKEVCIRHLR 119
XP_056679161  49 NQQSPVNVHPN-------YGPSS-PSSSNSGSYKGSDSSpIMRRPGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLK 120
XP_059730268  48 NQLSPVNIHPS-------YAPSS-PSSSNSGSYKGSDCSpVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLK 119
EHB01050     208 NQLSPINIHPG-------YAPSS-PSSSNSGSYKGSDCSpVMRRSGRYMSCGENHGVKPPSPEQYLTPLQQKEVTVRHLK 279
XP_058131908  92 NQLNPLNVHPG-------YAPSS-PSSSNSGSYKGSDCSpIMKRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLK 163 nine-banded arm...
XP_003643281  14 rrrpsPPGRDT-------YGTSSlSSSSNSGSYKGSDSSpTPRRSAKYNLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLK 86  chicken
XP_011471585 137 TKLLESENKVCDRETEIEELKGQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDI 216
XP_028918807 322 TKLKESESQLQERETEIAELKSQLTRMRDDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 401
XP_006921737 135 ARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDI 214
XP_003226156  89 ARLKDTHERLQDRDSEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIEKDKGLQKYFVDI 168
XP_069035573 120 ARLKETLDKLQDRDTEIEELKTQLARMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVRSNLTEKDKGVQKYFVDI 199
XP_056679161 121 TKLKESESRLQERETEIAELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 200
XP_059730268 120 TKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 199
EHB01050     280 TKLKESERRLHGRETEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIEQLKQVIETMRSNLADKDKGIQKYFVDI 359
XP_058131908 164 TKLKESEHRLHERETEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 243 nine-banded arm...
XP_003643281  87 ARLKDTQERLQDRDAEIEDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLLEKDKGLQKYFVDI 166 chicken
XP_011471585 217 NIQNRKLESLLHSMELAQSGSsL-QDENPL----DFMCDSSDGS----------GRKMLrmeeggIELGDQGAEALADSG 281
XP_028918807 402 NIQNTKLESLLQCMEMAQNGC-F-REELCL----EYLVESPGQSvplspactplARGLA------LEDQAGALEELGETP 469
XP_006921737 215 NIQNKKLETLLHSMEVAQNGT-A-KEDGTG----ESAGGSPARSltrsstytklSDPAVcgdlppGDHPASSAEDGADSG 288
XP_003226156 169 NIQNKKLETLLQTMEVAQDGA-G-KEEGAA----ESAGGSPARSltrsstytklSDQGAadr-niGGSQTISVDDAADSG 241
XP_069035573 200 NIQNKKLETLLHSMELAQNGS-P-KEEAMGglisESAGGSPARSltrsstytklSDQAApek-naNDIPSFNGEETLDSG 276
XP_056679161 201 NIQNKKLESLLQSMEMAQNGS-L-RDEQCL----DYLCDSPEKSlppntaygkmADARA--------LEDQTIEEGAESE 266
XP_059730268 200 NIQNKKLESLLQSMEMAHSGL-L-RDELCL----DFPCESPEKGlalgaalgptEGALS--------PEEPATEEGADSE 265
EHB01050     360 NIQNKKLESLLQSMEMAHSGS-V-RDELCL----DLPCGSPKKSlalntplgkmTDGLS--------VDGQVTEEGADSE 425
XP_058131908 244 NIQNKKLESLLQSMEMAHNGS-L-RDELYL----DFPCESPEKSvtlntrfgkmAEGLS--------LEEQVTEEGADSE 309 nine-banded arm...
XP_003643281 167 NIQNKKLETLLHSMEVAQNGA-GlKEEGAA----ESAGGSPARSltrsstytklSDQAGger-tvGGSQTISVDEGADSG 240 chicken
XP_011471585 282 llVNDEMANSADIF--------------EQVFMSTAVDFSQDSSNNpgaagesgaLSEEEQMASASTAPLS--PKTlfsp 345
XP_028918807 470 --APDSLPSGLDLF--------------EEFMTAATTESGEVAVFQ---------SSAAPAPPDQMAPAVE--DSV---- 518
XP_006921737 289 fvANDDTMSRTDALeassllssgvdcgpEEASLHSSFSLGPRFPAS---------NTYEKLL---CGMEAGvqASC---- 352
XP_003226156 242 faAADDSLSRTDFLdqsslissgvdcgtDEISLQTNSTLGSRVPTS---------STYEKLMGSQQSVEAA--VQVs--- 307
XP_069035573 277 faGGEDSASRTDLLepg--------fflEDASLLTSCTAASRLHHS---------STYEKLVSGQSSVEMSsnNGHphhl 339
XP_056679161 267 llAIENVENSTDLF--------------EEIMMATTTEAGDLSLLH---------STSISSPFKTKAFEMG--PVTqee- 320
XP_059730268 266 llGADGAAPGEDVL--------------EELVTGAIPEP---------------------ELPGAEVVALG--GEAaavg 308
EHB01050     426 llVGDSMADGADLL--------------DDVVTATAIESGDLEPVP---------SSP-----EAQVLELL--Pv----- 470
XP_058131908 310 llVGDSMIDDTDLF--------------DEMVTSTTTESGNLALLH---------STPGA-----KVLEVL--PIAmdla 359 nine-banded arm...
XP_003643281 241 faGGDEAPGRPDLL-------------------E-GGEPCGRLPPS---------STYEKLLGLRGGVEAG--VQAs--- 286 chicken
XP_011471585 346 spcqqnTEDKGIQTELMPVSPDLQALL 372
XP_028918807 519 ------VMEQVVQLDMAPCGPGIEQPL 539
XP_006921737 353 ------MQERAIQTDFVQYQPDLDTIL 373
XP_003226156 308 -----cMQEQAIQTDFVPYQPDLDTIV 329
XP_069035573 340 --lfqdLKEQAIQTDFVQYNPDLDTIV 364
XP_056679161 321 ---dsmVTEQAIQTDVVPYSPDVEQLI 344
XP_059730268 309 rggrraVAERAVQTDVVPYSPAFSELL 335
EHB01050     471 ------AVEQAVQTDVLLFSPTVSELI 491
XP_058131908 360 --essvVVEQAVQTDVVPYSPAVSELI 384 nine-banded armadillo
XP_003643281 287 -----cMQERAIQTDFAHCQPDLDTLL 308 chicken
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