Conserved Protein Domain Family
DUF4595
?
pfam15283: DUF4595 
Domain of unknown function (DUF4595) with porin-like fold
Large family of predicted secreted proteins mostly from CFG group, but also from Burkholderia, Pseudomonas and Streptomyces. Function of these proteins is not known. A 3D structure of a representative of this family from Bacteroides uniformis was solved by JCSG and deposited to PDB as 4ghb. There is some overlap with RHS-repeat (PF05593) family despite lack of obvious repeats in the structure.
Links
?
Statistics
?
PSSM-Id: 494971
Aligned: 9 rows
Threshold Bit Score: 125.815
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q8ABF7          57 Fr-yEDAWLTG--YTYTQEVSIA-DLTEIISHs---LTIQYGNNRssVT--FTD---------EIGTERKYTLNEEGYAT 118 Bacteroides t...
WP_013548547    64 F---PSGWLQS--HSTIQSYMAIeEDIKQENI----TDIVYTDHR--AT--ITD---------DFGNISTYILNDKGYAT 121 Bacteroides h...
WP_009229027    56 IqtnEKGQIIS--MKS-----A--DKNIIF---------KYTEAVtrSIapSPDvimtvtgrdINKVVCNLYLNKDGYVL 117 Prevotella sp...
CCX48427        70 ftydAAGLIKT--VTD--------DSNETYIVdfatGTVTYREYNeeEIwhITN-------------------TDSGLIT 120
CDF22741        59 FnyqSGRLVYV-----------SsQLISSISPinftASLSYKSNQvkVVr-------------SDGNNIDITLNPNSLLI 114
WP_022101019    60 FtynDGRLTQA--AGTLRKPSADtDRTFSYt-----STLSYGPTSv----rMTN---------TSGERVGLQLNMQGLVG 119 Prevotellamas...
WP_008199239    55 Mi-dSEGKITQ-----------------GYFWedqiVSFSYSPTEilAT--------------TKGKSVKYYLNDSNLIY 102 Algoriphagus ...
WP_009227893    54 FqydKQGRLVS--VTLETNSDEGkEKNi--------ITYKYSENLieAQ--STG---------DREAVSTFYLKNGKIIN 112 Prevotella sp...
jgi:Prede_0833  32 FeydALGRVVRdvYSSEDAEEGVeFRTNTYAYsmnkIVQRYSEGSlmDTdsRTS-----------------ILKDGKIVK 94 

Q8ABF7         119 QCEY--------ASLDQKRQYTFLY------TDGYLT--------QVNEKIMPREGSsdAvvahTLSLQYDKGDLISTIS 176 Bacteroides t...
WP_013548547   122 VCTRq-------EAGGRTRTYTFSYltdtknNKSYLT--------NITEIQEDGTTY--A----SIDIDCNDLHSLRITW 180 Bacteroides h...
WP_009229027   118 KCDKidy--yyeDRPETNHMYNFSYd-----RDGHLV--------EA--TIKGGEEV--W------SWIYENGDItrver 172 Prevotella sp...
CCX48427       121 SVSStlteheesGVVITDVTWNFSYd-----SSGHLI--------EAVYEERGRGNS--DwmkgSTTLTWSNGLLLSAYG 185
CDF22741       115 STLR-----------MSSFVYNYNYd-----DNRRLIrwncayidPILGVSIKRSYG--N-------INYDENND----- 164
WP_022101019   120 QMTVnr------------nVYHFQYn-----SDGRMVswtrtifeSSLGELTEYRSS--A------TISYTPAGA----- 169 Prevotellamas...
WP_008199239   103 RAEL--------DQSGSLITLTFEYs-----EDEKLI--------RINNKSNNIEVK----------IGYENGNFTVFES 151 Algoriphagus ...
WP_009227893   113 STFK----------AEDVDIIKYTYd-----INDQLS--------KVTTKDN------------TINISWQKGNITQIIT 157 Prevotella sp...
jgi:Prede_0833  95 ETVVmnd--desGLPKSTYTLNFTYn-----ADNQLV--------KVETLAGSGKNI--N----IHEVTWADGCPSNIKT 153

Q8ABF7         177 PslpyesstgygklqtnyeagedinyyrlpcmlvADTYPLSFHREAL--------------------------------- 223 Bacteroides t...
WP_013548547   181 Kvdasyeqaytattiss--gnetanlseipilflSELYPLSLHPAAL--------------------------------- 225 Bacteroides h...
WP_009229027   173 t---------------------------dhgekdDEPWKLYYTSASHlspivnkgylmlfn-----------enipadln 214 Prevotella sp...
CCX48427       186 Tysevye-----------------------gesdswTNNITFEYDNaypnafcqytdevi-------------saidldg 229
CDF22741       165 ------------------------------------IRQIQYVEDENnadnvvtlnftpsakinlngllpegvseelgmk 208
WP_022101019   170 ------------------------------------LQQIVYNGTDSrrvlltftqsaqqnvngh---mpptvskemgid 210 Prevotellamas...
WP_008199239   152 E------------------------------------TPLEYSSDEpyintmilkhtpfyfa--------ntmvlaseik 187 Algoriphagus ...
WP_009227893   158 Qyk-----------------------------ndNIIHKFVYTNHSAknfiplseledc---------------ipvids 193 Prevotella sp...
jgi:Prede_0833 154 Yre------------------------------gVLVGEMNFTYDTSvtnpyiiaitnp---------------flhvld 188

Q8ABF7         224 ------FAGMLG----KPTQHLTTA--------SYPEKTSDTyterTEYTYSFDKNKKPVS 266 Bacteroides thetaiotaomicron
WP_013548547   226 ------YGKILG----EPLPALTAQ--------IIPDGNAESke-iVSYSYTTDERGIVTS 267 Bacteroides helcogenes
WP_009229027   215 elsfayFAGMLG----TSTKHLSL---------RVVTGGGE-----SNFSWTLNESRYPTS 257 Prevotella sp. oral taxon 299
CCX48427       230 giepfmFVGVLGigpnKYPT-------------KIIDNDSQEy---SDVQYSLNAQGLVKS 274
CDF22741       209 gleylyYGGLLG----KSTYHLVESiey--qyaKTPDNNHT-----VTYQYGDNGsngniv 258
WP_022101019   211 gfehlyYAGLLG----KAPTMLPQSityeypdaAVPTAATT-----TTFEYGVHANnvtlc 262 Prevotellamassilia timonensis
WP_008199239   188 gcnilyGQGYFG----KLPQNRIISlrintgaqTYPANKF------YAFSYNFDENGKLTS 238 Algoriphagus machipongonensis
WP_009227893   194 vdpilfMQGYYG----KYVTNLVETaftnhtpiLTPTDEVEN----ITYTYTLDNKGKVVK 246 Prevotella sp. oral taxon 299
jgi:Prede_0833 189 yeailpYGQLLEdsygEPVKYAMRSvkytehvsHSYDWDPRDd---FELAYTKNAKGEVVS 246
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap