Conserved Protein Domain Family
BBP1_N
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pfam15271: BBP1_N 
Spindle pole body component BBP1, Mps2-binding protein
This N-terminal domain of BBP1, a spindle pole body component, interacts directly, though transiently, with the polo-box domain of Cdc5p. full length BBP1 localizes at the cytoplasmic side of the central plaque periphery of the spindle pole body (SPB) and plays an important role in inserting a duplication plaque into the nuclear envelope and assembling a functional inner plaque. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge.
Links
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Statistics
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PSSM-Id: 373701
Aligned: 11 rows
Threshold Bit Score: 142.572
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6FSH0        11 GGLKGVYKWTVDALFGSGVSPSAKYRGlnhgssrqrYSQDDTNYS-------------RYKPLSSMRSRSRSNSWSvp-- 75  [Candida] glabr...
XP_003686846  16 GGITGLFKWTKDALFGSSVSPTRKYKE---------FAQDDTNYKyqrfn---niyheNNDECTVEHGRSRSSSWTg--- 80 
A7TDM3        15 GGFGVLFKWTKDALFGSRITPSRKYKE---------FAQDDTNYKi-----------kRSVGKSAVGRRSRSNSWS---- 70  Vanderwaltozyma...
C5DBV2        10 HSTGGLYRWTMDALFGRQISPSRKFKE---------VSQDDTNYNmks-------hkdKQWDGHGFQPRTRSSSAS---- 69  Lachancea therm...
CCE90037      19 GGYAGLYRWTMDALFGSRVSPSRKYKE---------FAQDDTNYKre----------gRRRVRSPESTIMRSNSWS---- 75 
C5DT56        12 GGIHGLYRWTMDALFGSRVSPSRKYRE---------FAQDDTNYKsrdelfkgsykdgNS--------RGRSNSWS---- 70  Zygosaccharomyc...
Q12365        10 GGIFGLFKWTKDALFGTDISPSMKYKDqeerrdrsrYAQDDTNFSmk----------fGNDSNRRSTNLSRSNSWS---- 75  Saccharomyces c...
EJT43869      10 GGIFGLFKWTKDALFGTDISPSMKYKDqperrdrsrYAQDDTNFGin----------lGNGSSKRSANISRSNSWS---- 75 
CCF58692       8 GTSSGLFKWTMDALFGTKISPSKKYKQn-------fYSQDDTNYN---------------NMRRTRLQKSRSNSFD---- 61 
CCC70989      16 GNSSGIFKWTADALFGTKKH----------------ASQDDTNNNln----------yDNNNAGSTKLHSRPSSWDgsl- 68 
XP_003670678  23 PGNSGLFKWTIDALFGPKKEPHM-------------LSQDDTNYNnmnhh----rrmnKTRESPLTELKTRSNSWDgssl 85 

Q6FSH0        76 --vPQDPSFYKRYDLLPPi-----------------------------------sSDDEDYSeedklqygAN-------- 110 [Candida] glabr...
XP_003686846  81 ---GSNQAFYDKYDLLRDplvnddkyrknkvrfshqryqtgmdesthegnyvnvkNMQQDLDy-------IM-------- 142
A7TDM3        71 ---GLDSSFYQKYDLLED---------------------------------------EDEDDdekvfgmpSHlvgsggsr 108 Vanderwaltozyma...
C5DBV2        70 ----FDRSFLQRYELLQD---------------------------------------EEEQD------------------ 88  Lachancea therm...
CCE90037      76 ---GLDSGFYRRNDLLPP-------------------------------------SIEEDME------------------ 97 
C5DT56        71 ---GLDPNFYRRHDLLPL---------------------------------------EESQS------------------ 90  Zygosaccharomyc...
Q12365        76 ---GLDSTLHRKYELLPE-------------------------------------YNENGFNsiv--------------- 100 Saccharomyces c...
EJT43869      76 ---GLDSTFQRKYELLSE-------------------------------------HNENGVDsv---------------- 99 
CCF58692      62 ---GFSPTFCNKYDLLHN---------------------------------------DKTDS------------------ 81 
CCC70989      69 rdmGLSSSFYKKYDLLSP---------------------------------------EKPKT------------------ 91 
XP_003670678  86 snlGLDSSFYRKYDLLSPsnnm------------------------------qlqQQEQQQQry---------------- 119

Q6FSH0       111 ----------------SNRGSPMVKGLMNPAPVVPKQQNNGygefdr---------rstnplFTDPTDTFARRktssslM 165 [Candida] glabr...
XP_003686846 143 ----------------DPERRLKIEKLLAPVEIHPNSMSNAg--------------------YNDNTDTFANK------T 180
A7TDM3       109 scngddivgkavpfglDSQRRKRLQSLLDPVDLHP---------------------------MREDVDTFANNl-----K 156 Vanderwaltozyma...
C5DBV2        89 --------------------------IMRPVRSPARPYLSAghaagq----------daalaNDESTDTFSNKr----qR 128 Lachancea therm...
CCE90037      98 ----------------VPRPIESSNSLLNSSRVYRRP-------------------------EEQPTDTFAAR------- 129
C5DT56        91 ---------------------SSKSSLMDPVDLHPRAPASP---------------------VLDTTDTFGAK------K 122 Zygosaccharomyc...
Q12365       101 --------------ngDHHSKERIRSLRSPAPIVPREPLRN-----------------------EPTDTFGHR------L 137 Saccharomyces c...
EJT43869     100 --------------dnNYYYKDRIRSLRSPAPVVPREPLHN-----------------------EPTDTFGHK------L 136
CCF58692      82 ----------------LPSYHDGLDNLMSPIHLATKNKGQH------------------------HTDTFANK------- 114
CCC70989      92 ------------------RHTVDDEILLSPIHLKQSFPTYVn--------------------DKDPTDTFYRK------- 126
XP_003670678 120 --------------nhNTKYNDIRNSLMSPIHLRPSMVTNEqqknensllrhqlynhdedppNSEPTDTFQWR------- 178

Q6FSH0       166 NNYRSSTEGIG-------DtafiEETRNINingrDPLIAKLFGR 202 [Candida] glabrata CBS 138
XP_003686846 181 NGFRKTSTLYD-------D----VKVPTQD----PAFLSALFRK 209
A7TDM3       157 FHNTSKLDSFD-------Dl---MQTPRQD----KEFISKLFGK 186 Vanderwaltozyma polyspora DSM 70294
C5DBV2       129 FKGKFSGPKYH-------DeslkFRAPAKN----DPFISKLFQR 161 Lachancea thermotolerans CBS 6340
CCE90037     130 --RRRLGDDGE-------DhsivLQSPQQD----DPLISKLFQK 160
C5DT56       123 GSWRRS------------EstieFKSPSAD----DPVVSRLFEK 150 Zygosaccharomyces rouxii CBS 732
Q12365       138 HTKRRTINELS-------NsqipFIPPQED----DPLLSKLFNK 170 Saccharomyces cerevisiae S288C
EJT43869     137 HTKRRTANEFS-------GaqipFMAPHED----DPLISKLFQK 169
CCF58692     115 -NLKK-------------DyifqYKSPQKD----DPLISRLFHD 140
CCC70989     127 --NRGRANRRS-------DglpsFKSPTKD----DTLLSRLFKK 157
XP_003670678 179 -NNRSKISSNNnnhrqdmDndipFRPPKDN----DTLLSKLFGK 217
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