Conserved Protein Domain Family
DUF4592

?
pfam15262: DUF4592 (This model is not part of the current CDD release)
Domain of unknown function (DUF4592)
This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.
Statistics
?
PSSM-Id: 521740
Aligned: 13 rows
Threshold Bit Score: 101.388
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_005037638  144 PTMKLGPP---PPFg-LHAKRTDDAGTSSEDDGLPRSPPEMSLLHeslisgmrtrfSDSHKHLSSLSLAGTGSEEEEQIT 219 
XP_025754138  155 QAIKLGSP---PSL--MCVKRAEDPATMSEDDGLPCSPPEYTTVH-----------TNQAQANSSISLEGIDSDEDRLSC 218 
6_pfamImport    1 PPLRLCQPgisPFYikSDTISKDFEEISVDDDESPKTPQKKLLPQnilm----lkkSSLEPSSGPVH------------- 63  
1_pfamImport    1 QNIRLGPP---PLV--TPSRRAEDTGASSEDDGLPRSPPEISSVHegl-----arfTDTYRHLSSLSLAGTGSEEEEQSS 70  
2_pfamImport    1 KNIKFGQH---PPSa-IPMKKADSGEPRFEEHPFLTCPVESVPEQalvlvdteskpSETPGTPSPLNLPAARSEMEEKAA 76  
XP_051676213    8 KNIKFGQR---PANa-LPVRKADGGEASLEEGPLLPRPMETQTPWdvvlsdtenkaGHTPGSPGAVNPPGGGSDMEEKVA 83  
XP_069049581   44 HNIKFGQK---PTS--TSFRRSDAAEGSSDDEDVPRSPLKVVAQIeaepvdtemkdSADLPKNGHTTEASTRTSEVKQDT 118 
XP_025758974   19 QGIKFGQR---PPS----LRRSEGDEGSSDEEEVPRSPLKVLAQVeae------------plRTEPKQVQGGQPFGPHSP 79  
7_pfamImport    1 CNVKMGPP---PPPgsLPTKRGDDAGMSSEDDGLPRSPPEMSLLHdig-----pstTIKVCVVSSSRPQSPDQLFSRQAS 72  
XP_007501166  130 YNMKLGPP---PPCg-IPTKRADDAGMSSEDDGLPRSPPEMSLLHditatttttkfSDPHKHLSSLSLAGTGSEEEEQVP 205 
4_pfamImport    1 QNIKLGPP---PLV--VPTKKLDDAGASSEDDGLPRSPPEVSLLQeamar-tlykfSDPCKHLSSLSLAGTGSEEEEQKK 74  
XP_029684224   19 QGIKFGQR---PPS----LRKSEEDEGSTDEDDAPQSPLKVLAQVepe-----psnTE--------SKVYGTQQVEPHST 78   torafugu
XP_064422621  138 QNIRLGSP---PVV--ITTKKLDDTGTLSEDDGLPRSPPEISTLHdvltc-stsrsSNPVQRHSSLSIGGTDSEDEQMSS 211  coelacanth
XP_005037638  220 l-GSSSRSRSTDgqlftrhgststesprtstdstiSPTANFDTPPELSAFLDNSAAKHKLLIKPRNQRFSRM 290 
XP_025754138  219 --AASSRAVSPL-----------------------VVPGDFSQPASPFVCLDNSAAKHKLALRQKARRRPAS 265 
6_pfamImport   64 -----SQPYTAFamlts--------------psstQLPIGFSTPATTQGYLDSSGAPHMMVLNPQNQKKNLQ 116 
1_pfamImport   71 s-QPSSRPLSPVskpssrpts-----pqspdapvsSPSTDFASPPQSTACLDSSAARHRLSVKPRKQRASAR 136 
2_pfamImport   77 p-VKPSRPKRLFssa------------------gtIESVNLDAIPLAIARLDNSAAKHKLSVKPKNQRVSRK 129 
XP_051676213   84 p-VKPSRPKRHFssa------------------gtIESVNLDAIPLAIARLDNSAAKHKLAVKPKNQRVSKK 136 
XP_069049581  119 p-VKSPRQRRAVlas------------------gtIESINLDAVPRSASRLDNTAAKHKLAIKPKNQRASKK 171 
XP_025758974   80 p-VKSPRSKRVLplt------------------gtIESINLDAVPQSVPRLDNAAAKHKLSVKPKNQRVSRK 132 
7_pfamImport   73 etSASPRTsds----------------------smVPVADFDYPPEFSSCLDNSAAKHKLLVKPRNQRSSKM 122 
XP_007501166  206 l-GSSSRPLSPDqlfsrhasdtm--tsprtsdsslSPLADFDYPPEFSSCLDNSAAKHKLLVKPRNQRSSKM 274 
4_pfamImport   75 iiRPSSRPLSPVarqssrptsp---maqtsfsssvSPAVDFDSPPQVSACLDSSAAKHKLSLKPRNQRSGTK 143 
XP_029684224   79 p-VKSPRTKCALppt------------------gtIESINLDALPQSAPRLDNAAAKHKLSVKPKNQRISRK 131  torafugu
XP_064422621  212 --GASSRPISPVpssvsmi---------ptlpgnsILPVDFSSAATTLGCLDNTAAKHRIALNPRKQKAFTK 272  coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap