Conserved Protein Domain Family
GTSE1_N
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pfam15259: GTSE1_N (This model is not part of the current CDD release)
G-2 and S-phase expressed 1
This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localised to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.
Links
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Statistics
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PSSM-Id: 521737
Aligned: 23 rows
Threshold Bit Score: 167.905
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001123972  29 FLLLEDEKFDFDLSLSSSSANE-----DDEVFFGPVGHKERCIAASLDLNRQ-VPEQPLAPGSGSPCTWSPLTGEKFVEV 102
XP_005988504   6 VTFITEEEFDFGFSFSN-SWEDecdetEDEIFVGPVKHLERCVAKSIDIN---IGNNESQRNNECLTNWSPPTADKLEEI 81 
8_pfamImport   1 IPLLTDEKFDFDLSLSPASGNE------DEVFVGPLGHKEKCIAVSTEAKRS-TEK--SEPASDEKLMWSPLTGEKFVEI 71 
XP_015208148   9 FVLLTDERFDFDISLSPASGNGdd-enDDEVFVGPVCHKEKCVAAGIKVQVK-EKENCQMEQSDECANWSPLTGDKFVEI 86 
XP_011605872   9 LFFLHEEKFDFDMSMSPASSNGd----EDEVFVEPVSRNERCVSVNV---------KTQLDGRQLRTSWSPLTGDQLEAV 75 
7_pfamImport   1 LFFLHEEKFDFDISMSPASSNGde--dEDEVFVEPVSHKERCTSTNV---------ETQLSDGQLRSSWSPLSGDQLEAV 69 
XP_023182407   8 LCFLQDEKFDFNVSLSPVSSKGee-edDDEVF---VGHTEQCVSTDV-------SSQPEEGGGDVQAVWTPLTADQLEAV 76 
XP_040020000   9 VFFLIDEKFDFDVSLSPASSNGd----EDEVFVGPVGHAERCVSANV---------ASLASGGGVRTSWSPLNGEQLDAM 75 
XP_006002493   1 ------------------------------------------------MTHE-KAHEHQIVNLP---NWIPLKGDQFVEI 28  coelacanth
NP_001026503  29 FPLLADEKFDFDLSLSPASGSE------DEVFIGSLGHKEKCIAVHI--EAKrSAEKKRVPISDEKLTWSPLTGDKFVEI 100 chicken

NP_001123972 103 YKEAHLLALQIE-----CHSRREVAQAAKPRSAVS---QAKETFVQDSQLKISLFEKEQKRDKSPLSLKRETFCLPSS 172
XP_005988504  82 TREANQLAAQLEk----CTLKEKENSYRQKNDGSI---TNSFKFEKDTKGKIRLLKEERENRKSPRSPRRETYIVKDS 152
8_pfamImport  72 FKEAHLLALQIE-----RGSKTEQDKISQAEEQEK---EIIEKFVEDSKSKLKILRNENI-EQSPRAAKRETYCVWDS 140
XP_015208148  87 FKEAHLLARQFE-------KSSDSIHKKELNGGKN---EVVEKFVEDSKSKINIFNTPKNAALSP--IKRETFCVQDS 152
XP_011605872  76 CQEAHKLASQLQsg-erSQSHSEDDKDNEATAAVT---TQPDEFVQDSQAKLHVFEQSNR-VLSP--IKRETFCVQES 146
7_pfamImport  70 CQEAHRLASQLQgg-erSRSHSEHEDTTSAVM------TQPEEFVQDSGAKLNVFEQSNR-VLSP--IKRETFCVQDS 137
XP_023182407  77 CEEAHRLASQLQcrephVQKTNTTHTASDVDMNSM---ATTEEFIQDTEVKLGLLDHTAS-SLSP--IKRQTFCVQDS 148
XP_040020000  76 CQEAQRVAGQLQ--------------CASLLVPPSvpdEATGAFSQDAEAQLAAVDRRAS-ALSP--VKRQTFCVQDS 136
XP_006002493  29 FKEAHLLALQLE-----KNGSTEQTKEKGQDKPRN---GAVERFVEESKSKLKMFQKGKE---TPGAIKREIVCIQRS 95  coelacanth
NP_001026503 101 FKEAHLLALRIE-----SGNKGEENKISQSEENGD---ETSEQFVEDIKSKMKILKSHHI-EKSPRAVKRETFCVGDS 169 chicken
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