Conserved Protein Domain Family
FAM222A

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pfam15258: FAM222A (This model is not part of the current CDD release)
Protein family of FAM222A
This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.
Statistics
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PSSM-Id: 521736
Aligned: 10 rows
Threshold Bit Score: 658.822
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002937649  27 KWDTTQKMRSAQHPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--SGQRYSPYP-LQVSTKTGLLA 103
2_pfamImport   1 KWETTQKMRSASYPTP-ELDAYAKKVANSPLTIQIFPNSVKVPQRKHIRRTVNGLDTslSGQRHSPYP-SQVSSSQGLLA 78 
1_pfamImport   1 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDT--SGQRYSPYP-SQASTKAGLLA 77 
4_pfamImport   1 KWETTQKMGSASYPTPaQLDAYAKKVANSPLTIQIFPNSIKVPQRKHLRRTVNGLDTslSAPRHSPYP-TQVSSNRGLLA 79 
5_pfamImport   1 KWDTTQRMRSAQCPTPaELDAYAKKVANSPLTIKIFPNSVKVPQRNHVRRTVNGLDT--GGPRYSPYPpSQPTAKAGLLA 78 
XP_003456183  27 KWDTTQRMRSAPFPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRNHVRRTVNGLDT--SGQRYSPYPsSQASAKTGLLA 104
XP_056909486  27 KWDTTQRMRSTPFPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRNHVRRTVNGLDT--SGQRYSPYPsSQAGAKPGLLA 104
NP_001070966  27 KWDTTQKMRTAHYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDT--SAQRYSPYP-TQAATKAGLLA 103
XP_030143749  27 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--SGQRYSPYP-SQATTKTGLLA 103
XP_006002399  27 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--AGQRYSPYP-TQASTKAGLLA 103 coelacanth
XP_002937649 104 IVKSP-AKGVLKDFDGTRARLLPESMMNPPSAPY--VAPSTLNH---P--QGL--------------------------- 148
2_pfamImport  79 VLRAP-AKGVVKESDGSRTRHFQKSAMNPHSGAY--GAQSTLNLsqpA--PHLqgppqkqcmvhpqslqqsmthamtlqq 153
1_pfamImport  78 IVKVP-AKGILKDFDGSRARLLPEVIMNPPSGPY--ITPSTLNL---P--QTV--------------------------- 122
4_pfamImport  80 VLRAP-SKDGIKEPGSGRARQLQKATMNPHNGSY--AAHSTLNLpqsA--HNLrgs------------------------ 130
5_pfamImport  79 IVKAPtAKGVVKDFAGTRARLHPEAMMSAPGGPYapAGASTLTLhhgP--QPL--------------------------- 129
XP_003456183 105 IVKVPtVKGILKDFDGSRARLHPDVIMNPPTGPYqvASTSTLNHq--V--QNL--------------------------- 153
XP_056909486 105 IVRAPtVKGVIKDFDGSRTRLNPEVIMNPPTGPYqtASTSTLNHrhpL--PGL--------------------------- 155
NP_001070966 104 IVKVP-AKSILKDFDGTRARLLPEAIMNPPVAPYatVAPSTLAH---PqaQAL--------------------------- 152
XP_030143749 104 IVKSP-AKGIIKDFDGTRARLLPEAMMNPPSTPY--VAPSTLSH---P--QAL--------------------------- 148
XP_006002399 104 IVKPP-SKGVVKDFDGTRMRLLPEAIMNPPSTPY--VAPSTLNH---P-------------------------------- 145 coelacanth
XP_002937649 149 ----TRP----QQALQ-HAQALQH--AQSMQQQqqtlthsqsmPPGLQHPST-LQH-PQGL--P-QGLQHsqglqntqsi 212
2_pfamImport 154 pqtmPHPqavqQRSLA-HSHALQR--QQSLSQVltpeq-rlthPQSIQRQQS-LPH-PQPQ--QhQIQPHppvvpqqhls 225
1_pfamImport 123 ----PH-----PQGLP-RPQGLSH--QQTIQQQaqg----lrhPPGMAQPPS-LQH-PPGLp-PtQTLSH---------- 173
4_pfamImport 131 --srPAVetpqKQSMV-HPQTLQL--QRSLSQ---------------PMAPA-MPH-PQAL--QqKGAPH---------- 176
5_pfamImport 130 ----PRVpgqhQQGLPqHSQTLQPl-QQPQPQ-----------QQQQHHPPSaMPQhPQGMg-RtQPLSH---------- 182
XP_003456183 154 ----PRP----QQSLPlPPQDPPQtvHIPLPQQqv-------hTQSLRQPPPmAQH-PQGParLqTQSQH---------- 207
XP_056909486 156 ----PRL----QQSV--HLQDPTPtlQMPVPQQqd-------hTQSLRHHLP-MAQiSQGP--PrLQAQH---------- 205
NP_001070966 153 ----AR-----QQALQ-HAQTLAHapPQTLQH-----------PQGIPPPQA-LSH-PQSLqqP-QGLGH---------- 198
XP_030143749 149 ----AR-----QQALQ-HAQTLPH--PQSIPQH----------PQGIPQPPS-LPH-PQGI--P-QALPH---------- 191
XP_006002399 146 ------------QALP-HPRTLQH--SQILQQ-----------PPSLAQAQT-MPH-PQNL--PqQTLQH---------- 185 coelacanth
XP_002937649 213 pqpqtlqhtqsipqpqtlhhgqglpqtqrqqsipqnlqhqqtinqtlqhaqnmSQALQHT--QGLQRPQNMgsqhsqsmp 290
2_pfamImport 226 hlqtlkhpaapp--------------------qalhaqqgrtqdlrhmsdgaqLPSMQHA--QGLGGPQPApq------- 276
1_pfamImport 174 -----------------------------------------------------PPSLGHP-------PPGI--------- 184
4_pfamImport 177 --------------------------------------------------------LQHS--QGLAASQTLah------- 191
5_pfamImport 183 -----------------------------------------------------PPALQQ--------------------- 188
XP_003456183 208 ------------------------------------------------------PALGHP-----QGPPTV--------- 219
XP_056909486 206 ------------------------------------------------------PNFSHM-----QGPPTA--------- 217
NP_001070966 199 -----------------------------------------------------PQPMAQT--QGLVHPQAL--------- 214
XP_030143749 192 -----------------------------------------------------PQNMQQP--QGLQHPQTM--------- 207
XP_006002399 186 -----------------------------------------------------PQNLPRPqtQTLPHPQDMprpq----- 207 coelacanth
XP_002937649 291 qqnslqhATGISH-QALPHPANtllqpGLH-GARKMPDADAPPNVTVSTSTIPLSMAATLQQNRPPDLGSIVHQINQFCQ 368
2_pfamImport 277 ------aAGTALQtNSLQQPPP-----GAY-GLRKPPDADAPPNVTVSTSTIPLSMAASLHQNRPSDLSSIVHQINQLCQ 344
1_pfamImport 185 --------------LLQQQPLPp---lGLH-GSRKMADADAPPNVTVSTSTIPLSMAASLHQNRPADLSSIVHQINQFCQ 246
4_pfamImport 192 -----aaAGPPAMtNALQQPPP-----GTF-GPRKLPDADAPPNVTVSTSTIPLSMAASLHQNRAGSLSSIVHQINQLCQ 260
5_pfamImport 189 --------------QHLQQPPP-----GLQgGARKLPDADAPPNVTVSTSTIPLSMAGALHQGRQADLSSIVHQINQFCQ 249
XP_003456183 220 -------MLQQQHlQQQQQPPP-----GLQ-GSRKLPDGDAPPNVTVSTSTIPLSMAAGLNQGRQADLNTIVHQINQFCQ 286
XP_056909486 218 -------MLQQQHl--KQQPPP-----GLQ-GSRKLPDGDAPPNVTVSTSTIPISMAAGLHQGRQTDLGTLVHQINQFCQ 282
NP_001070966 215 -----------AH-QGLQHPHNp----lLH-GGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQ 277
XP_030143749 208 -----------AH-QSLQHPPNpllqpGLH-GGRKMPDADAPPNVTVSTSTIPLSMAATLQQNQPPDLSSIVHQINQFCQ 274
XP_006002399 208 ---tsqhQQNLSHgQTLQHPPNpllqpGLH-GSRKVPDADAPPNVTVSTSTIPLSMAATLQQNRPPDLSSIMHQIHQFCQ 283 coelacanth
XP_002937649 369 ARA-GIGTTSVCEGQIANPSPISRNLLINASTRVSTHSIP------MPSCV-GTSVDHsaaAAAISSATSGNIPMVNMSR 440
2_pfamImport 345 ARA-GMGSTSVCEGQIANPSPISRNLLINASSRVSCHHPAlg---sGPSCLmVGPSDKa-lAQTPIAALHTLPSLAATNS 419
1_pfamImport 247 ARA-GISTTSVCEGQIANPSPISRNLLINASSRVSGHAVPg----pLPSCV-LSSADQ---AATAQAGAVPASVMATVNR 317
4_pfamImport 261 ARA-GMGATSVCEGQIANPSPISRNLLINASSRVSSLQPGla---sVPGGLlMGAADH---AAAQSLHAPPAMAV----- 328
5_pfamImport 250 ARAqGAGATSVCEGQIANPSPISRNLLINASSRVSMHGGHpga-lmHPSCN-MGPLDKa--AAPAPVGAIPPHGMGTMNR 325
XP_003456183 287 ARAqGSGTTSMCEGQIANPSPISRNLLISACSRVSMHSNPatpgfpPPNCI-IGSQEK----APAPVGAHPPPSVAAMNH 361
XP_056909486 283 ARArGSGATSMCEGQIANPSPISRNLLISACSRVSMPSQPitpgfpPTNCI-IGPHEG--------LGCQPSSSVAVMNH 353
NP_001070966 278 TRA-GISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPt----pMPSCV-VNPMEHthaATAALPAAGPVNLPTGISR 351
XP_030143749 275 ARA-GISTTSVCEGQIANPSPISRNLLINASTRVSTHNVPt----pMPSCV-VNPVDH---AAAAIPPASVNVPMVNINR 345
XP_006002399 284 ARA-GINTTSVCEGQIANPSPISRNLLINASTRVSTHNVPt----pMPSCV-VNPVDQaavAAAVPPAASGNMPIININR 357 coelacanth
XP_002937649 441 VPtSYPGDLKPMG--------------------------------WNQHQLAHLQQMCGETGv-----qPGKPSQ-REI- 481
2_pfamImport 420 IP-AFHADPEKVH--------------------------------WAQHQLAHMQQPPEGAH-------PCKNPR-MEPp 458
1_pfamImport 318 VPaGYHGDVKQQQqqq--------------------------qrsWSQHQLAHLQHISEGGPgh----hPCKHSA-RDLp 366
4_pfamImport 329 -N-AFLPEPEKVHs-------------------------------WAQHQLDHRQQLPEGAH-------PCKTPR-MERp 367
5_pfamImport 326 MP-MYHSDMKQHPq------------------------------sWNQHQLAHLQHISDGVGh------PCKPPQ-RDP- 366
XP_003456183 362 LP-SNHTDLKQQHqlqqhqlhphqnqqqqqlqhttqqqqqqkmcaWNQHQLAHVPHIQNGGSh------LCKQPS-RDA- 432
XP_056909486 354 LP-SVHTDVKQQHhhlqqlqhn---------------tphqkmrsWNQHQLVQVDNMQNGGTl------LCRQPS-RDL- 409
NP_001070966 352 VPtGYPSDLKPVT--------------------------------WNQHQLAHLQQMCSEASgtpapglTGKHAAgREL- 398
XP_030143749 346 VPpAYQNEIKSVA--------------------------------WNQHQLAHLQQMCGDAAgpa--glAGKHPQ-REI- 389
XP_006002399 358 LPaGYQNDMKPLS--------------------------------WYQHQLIQLDHISRDGSgpk--elAVKHTH-REV- 401 coelacanth
XP_002937649 482 SAQVFPGKASSYSQELC-MNQSFGLKPPIEKPTPSPP---VNGLPGPLP-YTNGHYF--QPLWN-NILPTPNSDSMGSQD 553
2_pfamImport 459 TECAFPSRNLNYSHKLPnAAQSFNLKHASDKGRPSSP---INCPVGSMP-YINGHYM--QPPWG-GIPATAGNTGSGPQD 531
1_pfamImport 367 GGPGFPCKALNYPQELC-VGQPFSLKPPVDKPTPSPP---VNGMPGAMT-YTNGHYF--QPVWN-NILPTPNSDSSGSQD 438
4_pfamImport 368 PESDFPPHGLAYPHKL--PAQ-FALKQRADRAQPSSP---VRCPAAPMP-YANGHYL--QPPWS-RVPVAAGNAAPGPRD 437
5_pfamImport 367 --TGFPCKSMNYPPELC-MGQPYTLKPPLDKPTPSPPvvnNNNNNNGMAhYANGQYYhqPPVWG-SILPTPNSDSSGLQE 442
XP_003456183 433 ---TFHFKGMGYPAEVC-VGQPYSLKPPVERPTPSPPv-nNNGMPGPMAhYTNSHYFq-SHIWNsSILPTPNSDSSGSQD 506
XP_056909486 410 ---TFHFKGMGYPVEVC-AGQPYTLKPPIERPTPSPPv-nSSCMPGPMAhYTNGPYFq-SHVWSsSILPTPNSDSSGSQD 483
NP_001070966 399 AGPGFVGKAPAYPQELC-LAQSFHLKPPLEKPTPSPP---VNGMAAPLA-YPNGHYF--QPLWN-NILPTPNSDSSGSQD 470
XP_030143749 390 AGQNFPGKTSNYPQELC-MGQSFSLKPPIEKPTPSPP---VNGLQGPLP-YTNGHYF--QPLWN-NILPTPNSDSSGSQD 461
XP_006002399 402 AGQGFPSKTSNYPQEMC-MGQPFNLKPPVDKPTPSPP---VNGMQGTLP-YTNGHYF--QPMWN-NILPTPNSDSSGSQD 473 coelacanth
XP_002937649 554 LAMPFHGGQSAGGSl-----DCAG--G-THYRAIGGGSs----SQNNVMQTMDYLSgGDFQQSCFRDQSMASIGKVQR-P 620
2_pfamImport 532 LPGTFQGVQVAASA------NRIP--G-AKYRPGKEGPp----DQAKLMQNVDFLG-GDFQMPSFQEQNMGVMEKMHR-S 596
1_pfamImport 439 LAMPFHGGPPATSI------DCAA--G-AHYRAGAGSs-----SQTSVMQTMDYLA-GDFQQPCFRDQNLSMLGKMHR-P 502
4_pfamImport 438 LPAAFQPEPMASAT------ERTA--G-AKYRPMKEDv-----HQAKLMKSVDFLG-QDFHLGGFQEQRMEVMEKMHR-S 501
5_pfamImport 443 MPMPFLGTATGSTNpapggvDCAPagAtAHYRPQAGVAvv--aGQTNLMQTADYMG-GDFQTPCFRDQNLGLMRKMHRpP 519
XP_003456183 507 IAMPFHGAGPGGCTt----lDCAPpgA-PHYRLGSSSSsssssAQTNLMQTADYLG-GDFQTPYFRDQNLGLMGKMHR-P 579
XP_056909486 484 MAMPFHGAGPGGCAt----lDCGPpgG-PHYRPGISSSts-ssAQTNLMQTTDYLG-GDFQTPYFRDQNLGLMSKMQR-P 555
NP_001070966 471 LAMPFHGGQPTGAPl-----DCAAapG-AHYRAGTGGGpv--aSQNSLMQTVDYLS-GDFQQACFREQSLAMLSKAHR-A 540
XP_030143749 462 LTMPFHGGQPAGATl-----DCAG--G-THYRAGAGPs-----SQNNVMQTMDYLS-GDFQQSCFRDQSMAVLGKVHR-P 526
XP_006002399 474 LAMPFHGGLPGAVPi-----DCAT--G-THYRAGAGSs-----SQNNMMQTMDYLG-GDFQQSCFRDQSMGMMGKALR-P 538 coelacanth
XP_002937649 621 PMSRA-PEPADSRNIHVQHPGYR 642
2_pfamImport 597 AMGPV-QEPNNGSGVHSHHPGYR 618
1_pfamImport 503 SMSRA-PEPGDSRNTHIQHPGYR 524
4_pfamImport 502 AMGHI-QEVSSGAGLHPHPPGYH 523
5_pfamImport 520 PMGRVvAPPSEAHGQH---PGYR 539
XP_003456183 580 PLSRVgPEVGDGRTALIQHPGYR 602
XP_056909486 556 PLGRVgQEVGDGRTALIQHPGYR 578
NP_001070966 541 PGNRA-PDPTESRSLHIQHPGYR 562
XP_030143749 527 PMNRA-PEPTDSRNLHIQHPGYR 548
XP_006002399 539 TMGRA-PESTDSRNIHIQHPGyr 560 coelacanth
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