Conserved Protein Domain Family
DUF4589

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pfam15252: DUF4589 (This model is not part of the current CDD release)
Domain of unknown function (DUF4589)
This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.
Statistics
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PSSM-Id: 521731
Aligned: 14 rows
Threshold Bit Score: 183.9
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003755027  60 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSekgggsgpfdLTHLDFMTSDILSDSW-----------EFCSFLDI 126
3_pfamImport   1 EVVHDIDTLTGDLQLEEDglTDSSKTDTLNSSSSS----------LEKMKLFPEDFIFRPPalvdpvhvnplGVLTVLKK 70 
XP_004855554  52 EVVTQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagvggpfdLGHLDFMTADILSDSW-----------EFCSFLDV 118
XP_004758430  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagvggpfdLGHLDFMTADILSDSW-----------EFCSFLDA 118
XP_001928647  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagaggpfdLGHLDFMTADILSDSW-----------EFCSFLDV 118
XP_028921664  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkggg-glfdLGHLDFMTSDILSDSW-----------EFCSFLDV 117
5_pfamImport   1 -VVSQIDKLTSDFEFELE--PDDWTTATVSSTSSSdkga--gmfdLGNLDFMTSDILSDSW-----------EFCSFLEA 64 
XP_006626913  46 EVVHQIDSLTCDLQLEEEm-TDSSKTDTLNSSSSStttt--tassIEKVKLHSEGQIIKALpa-------ppAILTVLKK 115
Q1L899        48 EVVGQIDKLTSDLELDLD--ADDWTVATASSTSSSergl---ceaF-RLDFLGQDSLSDSW-----------DFCSFLES 110 zebrafish
XP_029686142  45 EVVHDIDTLTCDLQLEEDglTDSSKTDTLNSSSSSttttt-tassLEKMKLFPDDCISRLLpttpv-svnpsAVLTVFKK 122 torafugu
XP_003755027 127 S---------TPSDSGEGPEPARQ----------------PPTPDYRLMN--GGVLi-----PNGPR-------VETPDS 167
3_pfamImport  71 Php------pLPPPRLTPPRAEDHniknlphptfvlsgniSKGAGSLMRNg-GAFPm----kPNRDLfstmpcfISSDGG 139
XP_004855554 119 S---------TPSDSVDGPESSRP----------------GVGPDYRLMN--GGTPi-----PNGPR-------VETPDS 159
XP_004758430 119 S---------TPSDSVDGPELTRP----------------GAGPDYRLMN--GGTPi-----PNGPR-------VETPDS 159
XP_001928647 119 S---------TPSDSVDGPESVRP----------------GTGTDYRLMN--GGMPi-----PNGPR-------VETPDS 159
XP_028921664 118 S---------TPSDSGDGSEQPGG-----------------RQPDYRLMN--GGVLi-----PNGPR-------GETPDS 157
5_pfamImport  65 S---------TPSDSGDGSEQQQPq---------------GRQPDYRLMN--GGVLi-----PNGPR-------IGTPDS 106
XP_006626913 116 Pnp------pPPPPRLTPVRCDDLnktlp-------sgnpLKTNGTLLRNgaLALPgiqkkvPNGDVc-------cISKN 175
Q1L899       111 SsrrsarddtKPPPTTA--------------------------SVYSQMN--GGLPv-----PNGPL-------IITPDS 150 zebrafish
XP_029686142 123 Shp------pLPPPRLTPLRGEDHngknlphptlvlsgniSKATGSLMRNg-GVFPl----kPKRDLfsstpcfISNDSG 191 torafugu
XP_003755027 168 SSEEAFS-----ScppDPP-KGQQAHRTPG-------TRERVRFSDKVLYHALCCDDEEGEGEE-------EQEEDga-- 225
3_pfamImport 140 IPESGLVptlprP---MPL-LRHEKNKCPKargresrERERVRFSETVQYHGYCPDCDLQYDVDdtelhlqAELNN---- 211
XP_004855554 160 SSEEAFS-----A---GPT-KG---QRTPG-------TRERVRFSDKVLYHALCCDDE--------------TEEEag-- 204
XP_004758430 160 SSEEAFG-----A---GPV-KGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEEDGEE-------VVAEEev-- 214
XP_001928647 160 SSEEAFA-----A---GPV-KGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEGDGEEet----aAAAEEev-- 217
XP_028921664 158 SSEEAFS-----S---APApAKGQPQRTPG-------TRERVRFSDKVLYHALCCDDDEEGEQGee----dGEEEGggdc 218
5_pfamImport 107 SSEEAFS-----S---APS-HKAQHQRTAG-------TRERVRFSDKVLYHALCCDDD--------------EEADss-- 154
XP_006626913 176 IPEKVPI-----P---PPL-LRPDKDRCPQa------TRERVRFSEKVQYHGYCPDCDVRYDIKnrdvhlhTEPLH---- 236
Q1L899       151 SSEEASS-----S---THS-QSQKTSRTAG-------TRERVRFSDKILYHALCCDDDEDEDEDedgrdeeEDK------ 208 zebrafish
XP_029686142 192 IAESGLVptlprP---MPL-LRHEKNKCPKgparesrEKERVRFSEKVQYHGYCPDCDLQYDVDdaelqlhTELSD---- 263 torafugu
XP_003755027 226 ----aPSPNPPQTEPHVAPLKPL--------------------------LATCKPRRSPLTSrngghiptltpgsgqtrr 275
3_pfamImport 212 -----LRLSPVHCCFSSSPPPFPhqlmlengglss---shsfpptaktpPPCVPPHPPTAKP------------------ 265
XP_004855554 205 ----sLPPELPHTEPHEGALKPS--------------------------APLYKTRRSPLTSrrsgptlape----qtrr 250
XP_004758430 215 ----gLSPEPPRPEAHVGPLKPS--------------------------PAPYKPRRSPLTGrrpsstlape----qtrr 260
XP_001928647 218 ----gLSPEPPHAEAHAGPVKPS--------------------------PAPYKPRRSPLTGrrsgpttape----qtrr 263
XP_028921664 219 gggggPPPEAPQTE-TEATLKPAlppptckp----------rrsplpsrHVHLAPTLTV--Ggqprkv------------ 273
5_pfamImport 155 ----pLPEDPPEEASDPAHKAGQ--------------------------VTKTLPRRSPqqqkl---------------- 188
XP_006626913 237 -----TKLKPPHHC---LPPPPPlppfenggig------isishsfppvNPGSVPHPVAPKP------------------ 284
Q1L899       209 -----LDTDSERSPLAGSPVPPLpelync--------------reppagGSHTIPRKDALNPgcrkkl------------ 257 zebrafish
XP_029686142 264 -----LRLSPIHCcpssspptpalphelmlengglsashsfpptgtappPPCVPPHPPS-KP------------------ 319 torafugu
XP_003755027 276 vtrntsTQTVSDKSTQTVL 294
3_pfamImport 266 ------QKTILRKSTTTTV 278
XP_004855554 251 vtknssTQTVSDKSTQTVL 269
XP_004758430 261 vtrnssTQTVSDKSTQTLL 279
XP_001928647 264 vtrnssTQTVSDKSTQTVL 282
XP_028921664 274 -trnssTQTVSDKSTQTAL 291
5_pfamImport 189 -trnssTQTVSDKSTQTVL 206
XP_006626913 285 ------QKTILRKSTTTTV 297
Q1L899       258 -lrnssTQTVSDKSTQTLL 275 zebrafish
XP_029686142 320 ------QKTILRKSTTTTV 332 torafugu
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