Conserved Protein Domain Family
TAPR1-like
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pfam15251: TAPR1-like (This model is not part of the current CDD release)
Telomere attrition and p53 response 1 protein-like
This entry represents the Telomere attrition and p53 response 1 protein (TAPR1) from eukaryotes, including TAPR1 from human (also known as C16orf72/HAPSTR1), which is a multistress-responsive protein that functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. It may attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 which also promotes TAPR1's degradation. This family also includes uncharacterised proteins from fungi, such as YJR056C from yeast.
Links
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Statistics
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PSSM-Id: 521730
Aligned: 9 rows
Threshold Bit Score: 160.438
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDK45185      19 EDERRRNTslsgtgaaaasvtssqstsstsstsstadYTDLTTHFKDAAKAIASLYNtALGVQNltntndetpQKLTLKT 98 
XP_002616473  17 EQVSLVDL-----------------------------NRDLTNEFKNTAKAVASLYNaTSQAEC---------EHRSAKT 58 
XP_011456911  21 EEECIEELhsetnmeea------------lekqqelaEQKLWLQFQNSATAIAQLYK----DRH---------QGLSLWV 75 
XP_780508     23 EAQCLEELdrelepnlde----------rlpqekqfaSEKLWYSFQNCASAVTTLYKeRLNQSN---------IHIPLWL 83 
XP_046449254  21 ERQCEIELenepdldqa------------vlserdlsTQKLWYLFQNSATSVAQLFK----DRN---------QPQVLWL 75 
Q28HY5        25 ERQCLaeaeqedq----------------peeeaeqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGLSLWV 78  tropical clawed...
1_pfamImport   1 -RQCEdeddeddkgd-------------eealgpkseQQKLWHLFQISANSVAQLYK-GSECPQ---------SELSMWD 56 
XP_003972349  25 ERQCLaeaeqsdp----------------keeeteqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGISLWV 78  torafugu
XP_011602118  25 ERQCLaeaeqrel----------------seeevdndQDKLWHLFQNSATAVAQLYK-DRVCHQ---------QGLSLWV 78  torafugu

EDK45185      99 DFAQAARSVAVLYKYAQ----MSHPASFDQGYLNCIDDLLqiitndedveNWALTRR-AEITKLQKTSNKDNERERkEKG 173
XP_002616473  59 EFSNAAKAVASLYRTGS----NSNVLSMHKGYLDCLDDMLrvitndedieSWVLTRR-AELTNSYNTNQNHGAGSPgRAS 133
XP_011456911  76 PFQNAASNVTSLYKDGVdslhNCVDFGIQKGKQYRNRDIV----------AWVKKKR-RNIRREDLLAFLCGKNPP-ARN 143
XP_780508     84 VFQNAAGSVTQLYKESTdaqkGSLDLGISIGHQRRTRDIV----------AWVKKRR-RHIRREDLLAFLCGKAPP--GR 150
XP_046449254  76 PFQTAAGTITSLYKESTealrRSSELGIQAGYQRRAREML----------AWAKKRRgRNIRREELIAFLTGKSVPgSGA 145
Q28HY5        79 PFQNAATAVTNLYKESVdahqRSFDLGIQIGYQRRNKDVL----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143 tropical clawed...
1_pfamImport  57 HFQSAAMALTSLYKESRdaqqRSFNLGVQVGYQRRIKDVL----------DWAKKGQ-STILREDLISFLCGKVPP-DPP 124
XP_003972349  79 PFQNAATAVTNLYKESTearqRSYDLGIHLGNQRRNKDMI----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143 torafugu
XP_011602118  79 PFQNSATALTNLYKESVeahqRSFDRGIQIGHQRRNKDML----------AWVKKRR-RTIRREDLISFLCGKAPP---- 143 torafugu

EDK45185     174 ERERDRDRDREREREREKD--------------------IEsdsvLNFSQKSVVKNSLDSLQSKtafddgk--------l 225
XP_002616473 134 VSHNTHERLTDEAFPVRTN--------------------KDsshrLRDFDEASSENSKKNTTEKkfsnngtandlsssql 193
XP_011456911 144 RHASSMVRHSQSSRLSVERthsprlqgp---eslssgnePD----LQAFREAIALQGLNGAMSN---------------- 200
XP_780508    151 IRPSHGVPRSPSDRSSPRThsppreaqr----tglgepvdD----LQPFRDALALHGLNGAMAN---------------- 206
XP_046449254 146 SQPRHQMRMGPRPRVSLSDgmsashhgasalqhpleasaGDfepaLQAFREALSLPLPSSASSN---------------- 209
Q28HY5       144 ---PRNSRAPPRLTVVSPNratpte--------tgssveTD----LQPFREAIALHGLSGAMAS---------------- 192 tropical clawed...
1_pfamImport 125 PVPPHLPPVPPQLPPVPPHlpppyspkm--atessssldFI----LQPFQEAINLHELSGAMAS---------------- 182
XP_003972349 144 ---PRAPRAPPRVASRSapqet------------gssveTD----LQPFREAIALQGLSGAMAS---------------- 188 torafugu
XP_011602118 144 ---HRSSRANPRLTMVAPSranspae-------tgssveAD----LQPFREAIALHGLSGAMAS---------------- 193 torafugu

EDK45185     226 psdfaFQfaLDLRPPTAFRPSipplSVLHNPSQRN--------------LAIskknrfhqqilkkVHSSEDSSESESDD- 290
XP_002616473 194 htdyeFSlpQELMSHVVFRPSfpplSVSFKRSKKW--------------CDIkdrk-----mpisLQDASGSSDCDSDDg 254
XP_011456911 201 -----ITmgFSMSQGATASP-----QIGALPKSNG--------------------------------NMEELNRFILDEf 238
XP_780508    207 -----IG--------VSQSP-----SSHHSSSRRR--------------------------------HLSNHDLF-PEDl 235
XP_046449254 210 -----NS------------------GSSAKSNGRR--------------GSP-------------VHNHSELSAFISHEs 239
Q28HY5       193 -----IS--VRSSTPGSPTHV----SGSSNTGRRR--------------NGL-------------HD--VDLNTFISEEm 232 tropical clawed...
1_pfamImport 183 -----IS--VQSGPPSSPSQAgafsSNVATGDLQN--------------SST-------------LK--EDLSSCNSEDl 226
XP_003972349 189 -----IS--VRSGPPGSPTHP------AQPHGRRR--------------NGL-------------HD--VDLNTFIAEEm 226 torafugu
XP_011602118 194 -----IS--VRSGAPGSPTHV----SGSSSTGGGGggsssavptcrsrrNGL-------------QD--VDLNTFISEEm 247 torafugu

EDK45185     291 -----------------LKRVKifkdNT---SPSRKKKR 309
XP_002616473 255 itd----------adikKKRLA----HSlheVPKRQKRA 279
XP_011456911 239 srn----------ydtaRKRTSsp-dNTlidSPSRKKSR 266
XP_780508    236 vsh-----------pdsRKRSStniaPTvegSPSHKRSR 263
XP_046449254 240 ar-------------hkRPAPAspthDVimdSPTHKRSR 265
Q28HY5       233 alhl--------dnggtRKRTSaqcgDVitdSPTHKRNR 263 tropical clawed frog
1_pfamImport 227 alhl--------asggnLKRTSgqcdDVitnFPTHKRNR 257
XP_003972349 227 arhm--------dstatRKRGPtpcsDVitdSPTHKRNR 257 torafugu
XP_011602118 248 alhldstgsasaggggaRKRNStqcsDVitdSPTHKRNR 286 torafugu
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