Conserved Protein Domain Family
NCKAP5

?
pfam15246: NCKAP5 (This model is not part of the current CDD release)
Nck-associated protein 5, Peripheral clock protein
NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role.
Statistics
?
PSSM-Id: 521725
Aligned: 14 rows
Threshold Bit Score: 299.025
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_004071092   943 LQSAIEQKVMKGIEENVLKLQEQDRgGQGAEVKQKTSNGIASWFGLKKSKLPALS-RKADAAKAKDEKKEwkiNIPSVGR 1021
3_pfamImport     1 TVCTIEEKVMMGIEENLQKCQEQVK-VAASETKQKTGPSLANWFGLRKSKLPALSgKKADPPRGKEDKKEskiGSVLAGK 79  
XP_069927110  1448 LSPTIEEKVMLCIQENVEKGQVQTK-STSVEAKQKPGPSFASWFGFRKSRLPALSsRKMDVPKTKVEKKDt-kVLGFGNK 1525
XP_014587922  1465 LSPTIEEKVMLCIQENVERGQVHTK-STSVEAKPKPGPSFASWFGFRRSRLPALSsRKMDVSKTKVEKKDa-kVLGFGNK 1542
Q29SA9        1299 LSPSIEEKVMLCIQENVEKGQVQTK-SASVEVKPRAGPSFTSWFGFRKSRLPALSsRRMEASKSKVEKKDt--------- 1368 house mouse
2_pfamImport     1 LSPSIEEKVMLCIQENVEKGQVQTK-ATSVEAKPRPGPSFASWFGFRRSRLPALSsRKMEASKPKVEKKDa-kGLGFGHR 78  
5_pfamImport     1 LHSAIEEKVMKGIEENVLRLQGQDR-TPSTEAKHRNSSSIVSWFGLKKSKLPAPS-RRADPGKNKESl-----GGTPLGK 73  
10_pfamImport    1 PQSAIEQKVMKGIEENMLKLQVQDR-GQVVEVKQKTSNGIASWFGLKKSKLPALS-RKADVAKLKEDKKEwklNMPSAGK 78  
XP_064408393  1164 NQSAIEEKVMKGIEANMLKLQGQDR-VHVVEVKQKTSSGIAGWFGRKKSKLPALS-RKPETSKGKEDKREwkvTSSPVTK 1241 coelacanth
XP_056653163  1280 VPPTIEEKVMLCIQENVEKGQVQIK-SPTMQAKQKTGPSIASWFGFRRSKLPALSgRKMDISKTKVDKKDa-kSLGFGNK 1357 gray short-t...
XP_004071092  1022 DSVKVTsrCKEgveglnistlmEKAEGLRRALEEERAYVErsg-------rghS---------CEVVMDQAQGQLAVMYR 1085
3_pfamImport    80 AMKSDK--RKD-----------KKKNDSQQRDSVEGQSLSe-----------mNnklstimdhCNNQMGQIASQIQCTTA 135 
XP_069927110  1526 QLKSER--KKE-----------RKKTELQCEMGNELNRDTesvdga--dsgsqSktavkmpqnTYNQRKFEARSRLSPVT 1590
XP_014587922  1543 QLKSER--KKE-----------KKKPEPQCEIENELNRDTeladgp--dtglqSknnlktpqdIYDQMKFEPRNRPSPVT 1607
Q29SA9        1369 kLKSER--KKE-----------KKKAEVQSKIENELSRGTkkadgqspddglqSseslkvsqdIYNQMKLEPRNRPSPAV 1435 house mouse
2_pfamImport    79 QLKAER--KKE-----------KKKPE----VESELRRDAelagpa--dagfhSkssrkaaqdIYEQVKFEPRNRPSPVA 139 
5_pfamImport    74 GGKQEA--RKLeteslnisklmAKAEDLRKALEEEKAYLSrqg-------rgrPggptrgtsgSEVVLGQGQSQLTIMYQ 144 
10_pfamImport   79 DPKVATk-KKLeveslnisklmEKAEDLRKALEEERAYVNgvaldr--asrghS---------CEVVMDQNQSQLSVVYR 146 
XP_064408393  1242 EVKQAA--KKLeveslnismlmEKAEDLRRALEEEKAYINgisle---ksrlhP---------CDVLVEQTQNELKVMYQ 1307 coelacanth
XP_056653163  1358 QQKVEK--KKD-----------KRKSELQCETENEVNIKTemgnmp--dsvlkNkrnmktpqdVHVQMKFEPRNRLNPAT 1422 gray short-t...
XP_004071092  1086 GGRSDNFMQQLLNRVDGKEV----------ISMPQRRLSFDCKTSK-AVFTQQSDVI-SHTSSHNDMEK----------- 1142
3_pfamImport   136 FIGKDQFVKELLGRWVPSRTtrnk---lpsDTAVSQRTCHHNNSSS-CRAHRHTHTQaDSHRFSHCKFNkrkrykmdkrw 211 
XP_069927110  1591 CPANDAFMTELLNRVDKKAAqqte---sgsNDISCRNVLKGSSQSS-CLSGSSISSQgNHKKNTRTKADmetprdslikg 1666
XP_014587922  1608 CSTKDTFLTELLNRVDKKAAqqte---srsNNVSCRSVLKGSSQGS-CLTSGSISTQgSHKKIIKTKADmeipkgslike 1683
Q29SA9        1436 CPTKDAFMTELLNRVDKRASvqre---sgsKGVSCRSVLEGTSQGS-CFASGSVSTQgSQKKNIKTKVDmekpreslgae 1511 house mouse
2_pfamImport   140 CPTKDTFMTELLSRVDKRAAqqte---sgsSNVSCRSVSKGSSQGS-CRTSGSSSAQgNHKKTLKTKAEaempkgslvke 215 
5_pfamImport   145 G--TDTFMQQLLNRVDGKELppdnwqeskqDFGDFQSSVPETKGLQ-PLRSPRNGLIgQSANKSSGKKSs---------e 212 
10_pfamImport  147 EVTSDTFMQQLLNRVDERDSs--------gNGLAHRRLSFDSKKSR-PIFSSQRNGIiSHAKSRQEVAK----------- 206 
XP_064408393  1308 EMTTDNFMQQLLNRVDDKGAvyesrtgeksHPRSFQKASHESKSATaPLSAQRSTCPrQTIKDLQDTEK----------- 1376 coelacanth
XP_056653163  1423 CLTKDTFMKELLNRVDKKAAqqte---sgsNNVSYRSVSKDNSQGS-TLPSNSISTQeNHKKNSKTKADmetpnetlike 1498 gray short-t...
XP_004071092  1143 GSQRIGKLt--SDENLADSV----HSQHFAGSGASTYTLDSGIGTFPLPDCSSSGT-GRGLSKARGGAEHHST-DSPG-- 1212
3_pfamImport   212 FKEPYAEN---EERRIPDSS----CQDHMIGSGCQTRTLDSGIGTFPLPDSVTRAG-GRTSPNRXSRTVFAQLtSTLT-- 281 
XP_069927110  1667 ENENLQED---EEGPVADSA----FQSHIIESNCQMRTLDSGIGTFPLPDSGNRSM-GRYLCQPDSPEDTEPL-LSLQpa 1737
XP_014587922  1684 ANENLQED---EEDTIADSA----FQSHIIESNCQMRTLDSGIGTFPLPDSGNRSA-GRYICQPESPEDSEPI-LSLQpa 1754
Q29SA9        1512 VNEDVQED---EEDRVADTT----LQSHMIESNCQMRTLDSGIGTFPLPDSGNRSV-GRYICQQDSPEDTDAL-LPLQpa 1582 house mouse
2_pfamImport   216 TTENLQED---EEDTVVDSA----FQSHIIESNCQMRTLDSGIGTFPLPDSGTRSA-GRYICQADPSGDTEPD-LCLQpv 286 
5_pfamImport   213 LAQREAAP---AEDRLAEPI----PTPNFTACSSLTRTLDSGIGTFPPPDHGSSGVpSKNPPKPKPSRLDPPPtEHLSrp 285 
10_pfamImport  207 ATDLVCKGditSDESLTESV----NSQHFAGSGSSTRTLDSGIGTFPLPDYAGCVA-GKLVPKVKPRGDQEFS-APLGka 280 
XP_064408393  1377 AADLVNKDditSDESLADSV----TSQPFAGCGSLTRTLDSGIGTFPPPDYPSSPT-GISIPKLKSKFEQPAC-LPPGks 1450 coelacanth
XP_056653163  1499 VTESLQED---EEDTIMENRghspFQNHIIESSCQMRTLDSGIGTFPLPDSGNRST-GRHTCKPETSMESEPF-LSLQet 1573 gray short-t...
XP_004071092  1213 ----RAGRRARTLDREPTPQ 1228
3_pfamImport   282 ----SANRRAARRKSRPPAS 297 
XP_069927110  1738 l-paACSLRAQTLEREVPSS 1756
XP_014587922  1755 v-gaASSIRAQTLEREVPSS 1773
Q29SA9        1583 a-smASSARAQTLDREVPSS 1601 house mouse
2_pfamImport   287 l-caAPSIRAQTLEREVPSS 305 
5_pfamImport   286 ypltKVPQRARTLDREVPAV 305 
10_pfamImport  281 gpvtKVPRKARTLERELSSL 300 
XP_064408393  1451 lsvtRVPCKARTLERDMPSG 1470 coelacanth
XP_056653163  1574 l-psAPHIKAKTLEREVPSA 1592 gray short-tailed opossum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap