Conserved Protein Domain Family
HSD3

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pfam15244: HSD3 (This model is not part of the current CDD release)
Spermatogenesis-associated protein 7, or HSD3
Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterised by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).
Statistics
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PSSM-Id: 521724
Aligned: 12 rows
Threshold Bit Score: 510.082
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023483992   9 ATSVLLRCSPPDLFKGHLSTKSNAFCTDSSSlRLSTLHLVKNHMAVHYNKILSAKAIVDCSVPLSMSTSIKYADQQRREK 88 
5_pfamImport   1 NVTPVPRYSLAGPFKGHMSIKSSPYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQRRER 79 
7_pfamImport   1 AASVLPTFDPSCLFKGHLSTKSNAFCTDSSSlRLSSLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREK 80 
3_pfamImport   1 SSSVLPRSVPPCLFKGHLSTKSNAFCTDSSSlRLSTLHMVKNHMAVHYNKILSAKAVVDCSVPLSIGACIKYADQQRREK 80 
XP_003472388   9 ASPVLPRCSPPCLFKGHLSTKSNAFCTDSSSlRLTTLQLIKNHMAVHYNKILSAKAAVDCSIPVSMSASIKYADQQRREK 88 
Q80VP2         9 ATSVLPRYSPPCLFTGHLSTKSNAFCTDSSSlRLSTLQLVKNHMAIHYNKILSAKAAVDCSIPVSVNTSIKYADQQRREK 88  house mouse
XP_007472732  14 TNYVMPRYVPSSPFTGHLSTKSNAFCTDSSSlRLSTLYLIKNHMAVHYNKILSAKAVVDCSMPVSMISSVKYSDQQRREK 93 
XP_008114518  22 EYRAIPRYGPASPFKGHLSTKSNAFCIDSSSrRLSNQYLIRDHMAVHYNKILSAKAAVDCSVPKSRVNSIKFSDQQRREK 101
6_pfamImport   1 NVTPVPRYSLAGPFKGHMSIKSSPYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQRRER 79 
4_pfamImport   1 SNTILPRYDPPCLLKGHLSTKSNAFCTDSSSlRLNTLHLVKTHMAAHYNKILSAKAAVDCSVPVSISTSIKYADQQRREK 80 
XP_421307     60 ypavviprcgpaspfkgqlstksnafcidssrsltkqylirdhlMFHYNRILSAKAAVDCSVPRSSLSSIKLADQQRREN 139 chicken
Q9P0W8         9 ATSVLPRYGPPCLFKGHLSTKSNAFCTDSSSlRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSVSTSIKYADQQRREK 88  human
XP_023483992  89 LKKELAQCERGLKLTKTAMRANSKNNSKSL-NTLQKPSGEPHDEDGVLLKEVNGFPSFTRSRVTSSERLHLSAPKSS-KV 166
5_pfamImport  80 LKKKVSQCETKVISAQTGLQKTSTNNTRPSsADIVQSCASLQGNDEGDCFHYLESHLISSPRFAASCHSSQFLCQSS-RS 158
7_pfamImport  81 LKKELARCGRELKFTKTTVH--PKSHSKSLlNTLQKPSGEPQDENGLLIEEVNEFPSFTQSPVISSER--LSLPKSQ-NV 155
3_pfamImport  81 LRKEIAQCERELQGTKTTVQANSKNNSKSLlNTLQKPAEEPRNEGNMLIEEVNEYASFARSPGTSSERLHLSLPKSN-DS 159
XP_003472388  89 LKKELERCEKEFKLNKTSIQANSKKRLKSIfNTLQKPAGEPQNQ-GMLIEEMNGFPSFTKALLPSSET-QLRLRKSD-RV 165
Q80VP2        89 LRKELARCEKEFKLSKSAMQTNSKMNSKFFvNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGLHLSLPESS-KM 166 house mouse
XP_007472732  94 LKKELAQCEKELKSAKISTQTSNKFSPSPRlSPSRKLSEELPDK-DEETEEENDFPSLSKSLPPASDKQFPDFSILE-KS 171
XP_008114518 102 LKKEVEKCEKEMISSRNGSRTSSRESRRPMsAFYRKDSLEAEVN--RALPSYAPSEEKCFVRCLSFPEKYRIVPPSTgKS 179
6_pfamImport  80 LKKKVSQCETKVISAQTGLQKTSTNNTRPSsADIVQNYFIQISNSNGRFSNYLESHLISSPRFAASCHSSQFLCQSS-RS 158
4_pfamImport  81 LKRELARCEKELRLAKTIRQANSKNNSRSIlSTLQKPAGEPQDEADVLIEGIREFPSFARSRVPSSERLLLGPCKSD-KV 159
XP_421307    140 LKKKIARYEKEMSVGKSASRSSSRESGRLLsTSFGKSPLEVEDK-DNLFSCAEHTPYLSRALSPYGELGLLHSSPVK-RA 217 chicken
Q9P0W8        89 LKKELAQCEKEFKLTKTAMRANYKNNSKSLfNTLQKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSS-KV 167 human
XP_023483992 167 LTNSPEKNSSSS-QSSMDYTTSGPRKPCSGTVYGR-RPRSTVPNSYRFELVISKAPSGDLLDKHSELFSNRHlPFTPRTL 244
5_pfamImport 159 GQKATKPFYRSSsESGFRSPFTRREHSTQSYTSSS-GIFKSKISYNSFHDPNQKTYSGDLLQKHSHCFTEDK-PFTPKTL 236
7_pfamImport 156 LTNCTEKNSSCS-MSSMDYAASGSKKPSSGTSYGR-GPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHlPFTPRTL 233
3_pfamImport 160 LTGGTEKNFGSF-LSSIDCTTSRPRKTHSATSNSR-RPRST--NSHRSQLVVKKTSSGDLLDKHSKLFSNGHlPFTPRTL 235
XP_003472388 166 PMNGASQNGSSS-PSSVDCITSDPRNLGPGAVHGR-RPRSAFPSSHRFQVVISKAPSGDLLEKHADFFSNKQlPFTPRTL 243
Q80VP2       167 LMSGTQKHASTS----------PSRHSGCGHGCDR-RPR----SAHQFQVALAKTPSGDLLEKHSDLFSNKQsPFTPRTL 231 house mouse
XP_007472732 172 FRNETRRSYSTS------GTSSPRRQFCVSSRNAAtGSTKNTKNPRMFQLFASKAPSGDLLEKHSAHFTNQElPFTPRTL 245
XP_008114518 180 ARRTAQKASNASlLSSSTSTSSLQRLHSKMSWSSS-SDSITNKHSQKMHNAESKASSKDLLEAHSEYFTNGQqPFTPRTL 258
6_pfamImport 159 GQKATKPFYRSSsESGFRSPFTRREHSTQSYTSSS-GIFKSKISYNSFHDPNQKTYSGDLLQKHSHCFTEDK-PFTPKTL 236
4_pfamImport 160 LTSGTEENSSSS-LTSMGHTVSRPRKS-----------------PHRFQLVISKAPTGDLLDKHSELFSNKElPFTPRTL 221
XP_421307    218 RKHSRNRSNASYsNSSVSMSSTPRKRSGVSSRCSS-DSFVSISHSQRRQERSSTTYSGDLLDRHAELFTNSQkPFTPRTL 296 chicken
Q9P0W8       168 ITNGPEKNSSSS-PSSVDYAASGPRKLSSGALYGR-RPRSTFPNSHRFQLVISKAPSGDLLDKHSELFSNKQlPFTPRTL 245 human
XP_023483992 245 KTEAKSFLSQYRYYTPAKRK--KDLTDQRIQAETQAGLiSSFKP--DFETVETKNFKDSEL---Q--ASSCMTVGTQGKI 315
5_pfamImport 237 KKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDN-NRQTSllCFYKKPLDSFTDHEWsfeEhlIEDHLSYENLSKI 315
7_pfamImport 234 KTEAKSFLSQYRYYTPARRK--KNFTNRRIEAETQTEL-SSFKS--DFETVEIKNATDSEMnirQ--ASGCVSDGTKGRR 306
3_pfamImport 236 KTEAKSFLSQYRYYTPAKRK--KDFTDQRIEAETQTEL-SSFKP--DFETVETKDFTESEVtikQ--ASSCMTYGTKENI 308
XP_003472388 244 KTEAKSFLSQYRYYTPAKRR--KDITDPQIEGETQTEL-SSCHS--DLGTSEIKKLTDSEVnteQ--ASNYMTYGTKEKL 316
Q80VP2       232 KTEAKSFLSQYRYYTPAKRR--KDFSDQRMEAETQTEL-SSFNS--ELGTAEKTSSKDSEVninQ--VPNYTRNGAEDKI 304 house mouse
XP_007472732 246 KTEAKSFLSQYRYYTPAKRK--KDFQDQLIEAETQTEL-SSFKT--HFIRAELNNM-GSEViidEsdTSNYKIYGMKENF 319
XP_008114518 259 KSDAKSFLSQYRYYMPARSKl-LDVFNQQVEAETQTDI-SSFHI--ELEASEDDVGnf-----kK--IIKEVEDIEPEKV 327
6_pfamImport 237 KKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDN-NSFSD--NVGSPQEKSILPQEFnqsF--VQPCITYITSLKL 311
4_pfamImport 222 KTDAKSFLSRYRYYTPARRK--K---AQRIEAETQTEV-SSFNS--DFETAETENLTDSEVniqQ--APSCLTHGTREK- 290
XP_421307    297 ISDAKSALLGYRYYTAAQRQr-KKHCKQNVEVETQTDV-ISVPN--TDKASERKVMTEQRK----------MTVKTEDKI 362 chicken
Q9P0W8       246 KTEAKSFLSQYRYYTPAKRK--KDFTDQRIEAETQTEL--SFKS--ELGTAETKNMTDSEMnikQ--ASNCVTYDAKEKI 317 human
XP_023483992 316 SPLPVEV----PGSPWDKVKDgARQCSss-------------------sEEELLYLSFIEDITDEILKLGLFSNRFLERL 372
5_pfamImport 316 QNTGMGNtdqlYSLSRRDFKD-TFETAfhfripper-----mksptmrkEEELRYLEFIADVTNEILTMGLYSNRVLERV 389
7_pfamImport 307 APLPLQG----HELLWDKMRDgALQCSssravcqyslq-ppsgrkmysdEEELLYLSFIEDVTDEILKLGLFSNRFLERL 381
3_pfamImport 309 TPSPSQE----KGLPWEEVKDgALQCSsaralcqysvqpppsrrkiysdEEELLYLSFIEDVTDEILKLGLFSNRSLERL 384
XP_003472388 317 TPLSLQG----HDLTWDEIKDsAPRPSsqrtvcqysa--qrpwenkisnEEELLYLSFIEDITNEILKLGLFSSRFLDRL 390
Q80VP2       305 APLPSQG----QNLAWDSIQDgILQQSserascklste-fspdskiysdEEELLYLSFMENVTDEILKLGLFSNRFLERL 379 house mouse
XP_007472732 320 TPSQTLG----NSITWDKVKDdILHYPlsrasipyylq-pspvkkiqseEEELLYLSFIEDVTDEILKLGLFSNRVLERL 394
XP_008114518 328 STVSsprvtspgsaq------------------------rqairkiqaeEEELMYLSFIQDITDEILRLGLFSNRALEML 383
6_pfamImport 312 ---LLIG----YDIAWSHLKDeAREHKhtiiqkqermk-sptmrkvtaeEEELRYLEFIADVTNEILTMGLYSNRVLERV 383
4_pfamImport 291 TPLPSQK----YGLTWDEIKEgVLQRSaprtiskysl--qpsgrkihsdEEELLYLSFIEDITDEILKLGFFSNRFLERL 364
XP_421307    363 YNMDEPE----RGIA-------AFPYSflreaslyaeqpsarmnieaveEDDHLYLTFIEDVTNEILNIGLFSNRVLEQL 431 chicken
Q9P0W8       318 APLPLEG----HDSTWDEIKDdALQHSspramcqyslk-ppstrkiysdEEELLYLSFIEDVTDEILKLGLFSNRFLERL 392 human
XP_023483992 373 FERHIKQNKHHLEEEKMRHLLRVLKVDLG 401
5_pfamImport 390 FERHFEMNKHRLDNDKMRHLLDVLRHDLG 418
7_pfamImport 382 FERHIKQNKHHLEEEKMRRLLHVLKVDLG 410
3_pfamImport 385 FERHIRQNKHHLEEGKMRHLLHILKVNLG 413
XP_003472388 391 FERHVKENKHRLKEEKMRHLLHGLKIDLG 419
Q80VP2       380 FERHIKKNKHHLEEGKMRYLLHGLKVDLG 408 house mouse
XP_007472732 395 FERHIEKNKHHLEEKKMRHMLHVLKVDLG 423
XP_008114518 384 FERHIEQNKRHLNETKMRHLLEILKIDLG 412
6_pfamImport 384 FERHFEMNKHRLDNDKMRHLLDVLRHDLG 412
4_pfamImport 365 FERHIKENKHHLEERKMRHLLHVLKVNLG 393
XP_421307    432 FECHIEEYKNRLDESKMRHLLDVLKADLG 460 chicken
Q9P0W8       393 FERHIKQNKH-LEEEKMRHLLHVLKVDLG 420 human
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