Conserved Protein Domain Family
FAM53

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pfam15242: FAM53 (This model is not part of the current CDD release)
Family of FAM53
The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.
Statistics
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PSSM-Id: 521722
Aligned: 15 rows
Threshold Bit Score: 227.77
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003773489  14 MVTLITEKLQ-NQSLDDLTCKTYNINLYSSEELNKSGSLFPFEINvEENPWKVLNGGCPIRTEV--------------TK 78 
2_pfamImport   1 MVTLITEKLQ-NQSLNDLPCKAYSINLHSSEKLNQSGSLFPYEIH-EESPWRVISRACPIRTEAtknapfyfplcpfsRG 78 
Q66IH4         1 MVTLITEKLQ-NQSLDDLSCKTYNLNLHPSVKLNKSACLFPYEIN-EDSPWKVLNGTYPIRNEVnknsifsfstcpysAG 78  tropical clawed...
XP_003218652   1 MVMILTTALE-NKGADSLSCRA---ELHTPKKMSQGPTLFSCGIM-ENDRWRDLSRKCPLQIEQ--------------PS 61 
1_pfamImport   1 MVIIHPKTLEkKKGVDDVTCKASDSELQKPQKMSKGTALYACGVV-ESDGWRDLGRGCAFQKDP--------------GG 65 
XP_003441827   5 MVIIYPKTLE-KKGADDVTTKRTNFVPFQAQTMSQGTALFSCGLM-DTSRWRDMGHRCAIQRRP--------------VG 68 
XP_003961199   5 MVIIYKKTLE--KGAGDVKSNSTGLGPFQAQIMSQGAALFSLGLA-EASQWSDKSHGCAIQQRP--------------VG 67 
XP_023196365   5 MVIIYKKTVE-KKGGDDVTTKRTDLGT--AQTMSQGAALFSCGLM-ETSRWREVGTSCALQQRP--------------VG 66 
XP_005795537   1 MVTLITEQLC-KQSLEEPYHKAFTFNA--------SVSLPAVGSS-PTISWNSGKTTQEAS-----------------SD 53 
XP_002936879   1 MISMITEQLQ-KQSLEDLKCKSFSISLPLPDHPDPEGCSSPYHFVsEDRSWGLIS------------------------- 54 
XP_003773489  79 VSafpfpscpfssANMCLQWQKESPS-PSMVSGWISELNLN-------------------------------ENSGQPL- 125
2_pfamImport  79 AP-----------DSVGLQWQRDVTG-PSVLPGWISELNLN-------------------------------ENCGPPL- 114
Q66IH4        79 TS-----------GSYSLQWQNESSS-ASKVSGWISELTLN-------------------------------DSFGQPL- 114 tropical clawed...
XP_003218652  62 TNiwdc---lpdkSKESSIWQREAAS-TCSVTNLIKDLSLS-------------------------------DHSGNPS- 105
1_pfamImport  66 ASleclwgvlpgpYQGSRGWVKEAGA-ASAITNLIRDLSLS-------------------------------DAKGSPSa 113
XP_003441827  69 TSleslwdvlpevHTSSAHWDWDVGStSSTITNLLQDLSLT-------------------------------EA-SHST- 115
XP_003961199  68 TSleslwdvlpeaHEGSSHWDWDVSStSSTITSLLQDLSLK-------------------------------EG-LQST- 114
XP_023196365  67 TSleslwdvlpdvHRTSAHWGWDVGStSSTISSLLQDLSLT-------------------------------DA-SHST- 113
XP_005795537  54 THqsckayvladsC---DPWPRSCSGePLQGLEVSLTNKSF-------------------------------QS-SPP-- 96 
XP_002936879  55 ---------------------------HCPRIELEDGIRLGchhhsssslhfpvlsressphrrspshipeaGNSVAPP- 106
XP_003773489 126 APPPKRHCRSLSEPDELARCRSPWKPG-NSKVWTPVSKRRCNSGG---------SATLQRCNSG-----GSATLQ----- 185
2_pfamImport 115 APPTKRHCRSLSEPDELARCRSPWKPGsGSKVWTPVSKRRCNSGG---------SATLQRCNSH-----GGATLP----- 175
Q66IH4       115 APPTKRHCRSLSEPDELSRCRSPWKPG-NSKVWTPVSKRRCNSGG---------STTLQRCNSH-----GGGNLQ----- 174 tropical clawed...
XP_003218652 106 APPSKRQCRSLSFSDEMSSCRASWRPI-GSKVWTPVEKRRCYSGG-----------SVQRYSN------GFTTMQ----- 162
1_pfamImport 114 APPSKRQCRSLSFSDELSVCRPAWRPQ-GSRVWTAVEKRRCHSGG-----------SVQRGPCTl---pGYPAMQ----- 173
XP_003441827 116 APPSKRQCRSLSCSDELSGCRSSWRPQ-GSRVWTAVEKRRCHSGG-----------SVQR-SSIgnmqsGFAGMQ----- 177
XP_003961199 115 APPSKRQCRSLSCSDELGS-RSTWRPQ-GSRLWTTVEKRRCHSGG-----------SVQRGIGNaq--lGFPAMQ----- 174
XP_023196365 114 APPSKRQCRSLSCSDELSSCRSTWRPQ-GSRVWTSVEKRRCHSGG-----------SVQR-SGLgnsqlCFPAMQ----- 175
XP_005795537  97 -PPPKRHCRSLSVPEDLSQCRSTWHPS-ASKVWTPV-KRGCHSRG---------ASSSGSGASSlllcgPSSSFTssslh 164
XP_002936879 107 APPTKRHCRSLSVPEDLSRWRPIWRPS-GSKVWTPV-KRRCNSGGvgavlavqtQSPSQGVSSLrfqndPSASIRciq-- 182
XP_003773489 186 ---RSTSISLPQSVLSLQnvfp--------vtgFHTSPV-PRPSSASSGFVDS-------SEG-STSSSIRWNSA----G 241
2_pfamImport 176 ---RSPSVSLPQPSKQHVlslnnsafsvassgsFSTSPV-PRPSSASSGFVDS-------SEGsTASSGVPWHSG----G 240
Q66IH4       175 ---RSTSISLPQNPLTVKhifa--------asnCDTSPV-QRPSSASSGFVDS-------NEG-SAASNVRWNSA----G 230 tropical clawed...
XP_003218652 163 ---RSSSFSLPSRSNPLSs-------------fCDQSGFsNRFGCQPCQGMRR-------SAT-YGQASDIWGSDhssiE 218
1_pfamImport 174 ---RSSSFSLPARSNAFPqht----------acLPIAGFqPSPPSSSSSSTSE-------ATGdSAAGP----------- 222
XP_003441827 178 ---RSSSFSLPARSNTLE---------------LPSFTQrPPWSSGFTSLTPSssssvplSSDpSSQP------------ 227
XP_003961199 175 ---RSSSFSLPARCNTLE---------------LSCFSQcAPCPSAFTSLTLS-------SSEpSAPPL----------- 218
XP_023196365 176 ---RSSSFSLPARSDGQE---------------QLCFPQlSSRPSAFSGPTPN-------SSDpSAQS------------ 218
XP_005795537 165 sssSPNFFSLALSSDSSLsc------------gFPWDPCdTLKGACSASLATP-------SSCsSSPAPLVSHSI----- 220
XP_002936879 183 -anSPPFFSLALCRESP-------------------------------------------GPYtLSPTSVFWENSe---G 215
XP_003773489 242 PCDFNPRRRLSLSQEHIPEAGNLLPSANSTP-----------------------TSTPELSRR---QGLLRCRSQPCVLN 295
2_pfamImport 241 PYDYHPRRRLSLSQEHITDAGTLLPSASSTP-----------------------TSTPELSRR---QGLLRCRSQPCVLH 294
Q66IH4       231 PSEFNPRRRFSLSQEHITENADLSPSANSTP-----------------------TSTPELRRR---QGLLRCRSQPCVLN 284 tropical clawed...
XP_003218652 219 SSRIDIQRSLSCSHDQISFSEYCLPSANSTP-----------------------ASTPELTRRs--NGLSRSRSQPCVLN 273
1_pfamImport 223 -------RPLSLSHEQICLPEPRGPSADSSP-----------------------DSTPELGRRagpGGLSRSRSQPCVLN 272
XP_003441827 228 ---------LYLSHEQICLPEPRGPSPPSSP-----------------------DSTPELERRggqGGLPRSRSQPCVLN 275
XP_003961199 219 ---------LHLSHEQICLPEQREPSPPSSP-----------------------DSTPELERRggqGGLARSRSQPCVHN 266
XP_023196365 219 ---------LYLSHEQICLPEAEEPSPASSP-----------------------DSTPELERRggeGGLARSRSQPCVLN 266
XP_005795537 221 -----LHRRFSLSPVHIQIASVASLHPPPSPahvlahsfsgpehpslcpsptsaCSTPSCSRRdlhPALPRCHSQPCDM- 294
XP_002936879 216 PSCFPLQRRFSLSPVLIKEAGRFLPSTSSSP-----------------------PSTPELVRRq--QCLPRSQSQPCDLD 270
XP_003773489 296 EKKSRLKRRREEDV-RWNRPSLDFFKMTR 323
2_pfamImport 295 ERKSGLKRRREEDV-RWSRPSLDFLKMTR 322
Q66IH4       285 ERKTRLKRRRDEDV-RWTRPSLDFFKMTR 312 tropical clawed frog
XP_003218652 274 DKKVGIKRRRPEEV-KEQRPSLDLAKMTQ 301
1_pfamImport 273 EKKIGVKRRRPEEA-PEQRPSLDLAKMTQ 300
XP_003441827 276 EKKTGMKRRRPDDT-HKQRPSLDLAKMTQ 303
XP_003961199 267 DKKVGMKRRRPADS-QKQRPSLDLAKMTQ 294
XP_023196365 267 DKKIGVKRRRPADS-QKQRPSLDLAKMTQ 294
XP_005795537 295 -RKPRLKRRHDPDVlPCSRPGLDFSKMTQ 322
XP_002936879 271 TRKCGIKRRHEEDT-RWHRPSLDFYKMNQ 298
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