8OTZ,8SNB


Conserved Protein Domain Family
CFAP96-like

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pfam15239: CFAP96-like (This model is not part of the current CDD release)
Cilia-and flagella-associated protein 96
This family (previously DUF4586) represents Cilia- and flagella-associated protein 96 (CFAP96, also known as C4orf47). CFAP96 is an axonemal microtubule-associated protein (MAP). The EM structure of sperm DMTs shows that CFAP96 binds to tubulin and, similarly to other axonemal wedge-MAPs, binds deeper into the inter-protofilament cleft making extensive contacts with flanking protofilaments.
Statistics
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PSSM-Id: 521720
Aligned: 33 rows
Threshold Bit Score: 181.839
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8OTZ_W         8 TDMERIGLFSEMEYITVG------DKYvsq---fnrPFNESASKNrqil-----pggSKEMSNLQAGYFDP-HFVRIFEG 72  domestic cattle
A0CLN6        21 SQRERHGLFNQPPPLLIG------DQYnd------aLKSQGKEKGvl--------vnKKLQKKHEPTLFLEpGYTTL--N 78  Paramecium tetr...
XP_004040205  31 ATKQRFALFSQPPSLATG------Ddkq-----yqkIYHQRDENGkpitearniqstALKRGKAKDAYFSVlGFTTI--G 97 
A0CX61        23 ATVQRFGLFSSPVPLGLG------Dnsy-----dnkPRPARNEQGkpitsppnmkvtATQSGKIKSSYFSQlGFTTI--G 89  Paramecium tetr...
A0E6W5        26 AKKQRFGLFSSPVPLGLG------Ddsm-----emrKRPQRGENGkpitepsnmkvcATRTGRIRSSYFGPlSFTTV--G 92  Paramecium tetr...
XP_001566595   3 DTSAYGGLFQDPSYLSSDpdprktDPYdkkdaipsrYLGKSMTVGg-----------RVPPGQHPDAYFDK-KFLTLASS 70 
XP_003722339  75 DKSVYGGLFQDPPYLSSDpdpkktDPYdkkdaipsrYLGKNMTIGg-----------RVPPGQHPDAYFDK-RFLTLASS 142
Q4E651         3 QLSVYGGLFSDPPLISTDgdpkrtDPYdkmdtipsrYLGKGMSIG------------RSGTGQNAEVYFDK-KYLTLASP 69  Trypanosoma cruzi
XP_002508712  24 AGPDKYGSFSNPGSLNVG------VPYtgkdplaqgns---------rlrgvnmkapSAKMGKGNDASFDR--FKPLYQK 86 
Q57V66         3 HLSAFGGLFSDPPLVSTDidpkktDPYdkmdtipsrYLGKGMSIG------------RCPSGNGPEVFFDK-KFLTLASA 69  Trypanosoma brucei
8OTZ_W        73 E--------SYVNpnQVRRRYMMEEAKKNl---sKAFLPSNGEKKPCGLGSYYGTiggpvpfFSA--------------- 126 domestic cattle
A0CLN6        79 D--------PYKDqfKAKQIYDKERELAIkn--pNCFKPNDHVKSIKHSE------------FEHmkefn---------- 126 Paramecium tetr...
XP_004040205  98 D--------KYIDpdSINRQYELEKKKKIkq--dQVFKPPSGYKTIINSA------------FKHenedv---------- 145
A0CX61        90 D--------KYIDpeRKIRIQELEEKKKYanddkKNFVPPSGYKELVGGV------------YNHeadyei--------- 140 Paramecium tetr...
A0E6W5        93 D--------PYIDpeKVLTIYEKEQKKLCnk--eAAFKPPSGYKELMGSA------------YSHmkeydy--------- 141 Paramecium tetr...
XP_001566595  71 Eqngg--kpvgYDenKWCTTAKK-QTKKPis--dKEFRYSSYPERSTGPGSYYGC-------FQSrpyeymtepw----- 133
XP_003722339 143 Eqngg--kpvdYDesKQRTAASRTNTKNAis--dKEFCYSSYPEKSTGPGSYYGC-------FQNrpyeymtepwd---- 207
Q4E651        70 EqngnkdlgAFEDadTRMRREAMESKKKNis--eKVFLLPSYPKWSDGPGSYSGC-------FQDrpypfilpgen---- 136 Trypanosoma cruzi
XP_002508712  87 E--------PFQVsaAEKREARAKAEDGRi---qGPLVPAGMPKKSSGLGGYGGTlg---epFENedgepyfgwg----- 147
Q57V66        70 EqnnnksvgPFEDatTRMHRERREAKKHNis--nKDFLPPSFPKSINGPGGYSGC-------FQErpyefimpgeeggpk 140 Trypanosoma brucei
8OTZ_W       127 -----------QSKPKEKYEPPGKNLYTNPGKKGTgyGYANITIGKQ---------FSHssDLY----DAAKLNNKKE-N 181 domestic cattle
A0CLN6       127 ------dkvfnTRTPKGDVRTQARNFLTNPAKKGLgrTTTNNLFGQ----------IEYipDPY----DRQEELDRQD-R 185 Paramecium tetr...
XP_004040205 146 ------ynkknYRDADGKVLTQSKNITTNPSSK---------LQSKH---------YPHlpDQY----ERQRQLRIQ--E 195
A0CX61       141 -----pkgpnnHKGGDGRVKIGPKNVTTNPGSS---------SLGHF---------PKHekDEY----NRYRQFERE--K 191 Paramecium tetr...
A0E6W5       142 ------kkvesRKQTDGRVYSAPRNVTTNPRCK---------VLDKS---------IPYltDDY----NRYSDFERKArM 193 Paramecium tetr...
XP_001566595 134 -ddgkskkrraAKPKEEEEPTHLPNIKTNPAKKGTy-GYAGLLLSNP---------IYN--DNWkdehAAAEAERASKeR 200
XP_003722339 208 -dgkskkkkraPKPKEEE-PTHLPNIKTNPAKKGTy-GYPGLLLSNP---------SYN--DDWkkdyAAAEANRARReR 273
Q4E651       137 dkksrrrkkaaVTEVTDKNKSSLPNIKTNRTKKGTy-GVPGTLLDNP---------KYN--DNWrqemEKLDALRAKR-E 203 Trypanosoma cruzi
XP_002508712 148 --tadgeppkgLMKGDPSTQPKPRNIVTGPGKKGGy-GMRGYTLGEKksaggsageYKYvaTDY----DAERKADAA--R 218
Q57V66       141 skkskrkkkasSSEEDSKGKELLPNIKTNPSKKGTy-GYVGILLDNP---------KYN--DDWrkehEKLEAAEAKK-R 207 Trypanosoma brucei
8OTZ_W       182 EE-HRRLLKG-TAFKLNLY--PREyFDTnpy----mseKPLPPIKKVE--KKetv-------gnpFKPSSPGKKAG---- 240 domestic cattle
A0CLN6       186 IKhRSKFLPGtTRFITTSH--GNRpFTAdgilldgagyLSAKKRPLYKgaP--------------FRPANQNK------- 242 Paramecium tetr...
XP_004040205 196 MKkHQELLGEkAAFRSTVF--GRRnFFNdkktfgeeglNLKKRPQTN----Ikfnii---nhdapFKPSNPNKRVFiyii 266
A0CX61       192 IFnEQKMLKDkQPFKSTIY--TTDnFSTdkqifgetnlPKPTQVKEFKpnIMkhe--------apFKPSNPTK------- 254 Paramecium tetr...
A0E6W5       194 ESkSKEKe---QPFRSTVN--GGYtFEKdknifgvtkmPPQSQRKSPDlkSAkhe--------saFRPANGLK------- 253 Paramecium tetr...
XP_001566595 201 KQgPAPKALG-PPFHIPGV--SHSyIDE----------MPNTGVSGVYaaYEapadsaatknrkaKKETKAVPTLVhera 267
XP_003722339 274 KQgPAPKALG-PPFHIPGV--SHSyIDE----------MPNTGVSAVYaaYEapadsa-aekrkaKREAAAAPTLVhera 339
Q4E651       204 KNvPQPKPMG-SPFKTPGV--THDfLDE----------LHATGVSAVY--HYepveekspkrkgrVKSPAAVAVFTqerp 268 Trypanosoma cruzi
XP_002508712 219 AAhGKKLMAGkPDWKPTAPgkRGGpGVTgktlagpknlGGVCGEYRYKpeGPdpkfvpeppadypWAPPKPNK------- 291
Q57V66       208 KKlAPPKPLG-PLFRTPGV--IHDyLDE----------LPATGVSGVY--HFepadekpskrkrkNKQEAAGPTFVqera 272 Trypanosoma brucei
8OTZ_W       241 -------GMKAGTFDPYPSHSADPYV-------------------VKLKSPSSKS--AKVFHP--Pgg-pkSRPIESIMa 289 domestic cattle
A0CLN6       243 -------NGFQGTFEVL-QYMEEGVPdpk-------------tkqNTFQKLSATQtyENPWRPnsNgtfarPCPSVSq-- 299 Paramecium tetr...
XP_004040205 267 kkificyKGWNGTLSKFPEYKPNGek------------------qAKRQFMI-KE--KDPFKPkyCgeltrPTPTISCHp 325
A0CX61       255 -------SGETGCLSKYPQYKGDPlk------------------pTQRIDFV-KG--KDPFKPnhLmemvrPTPSISCFp 306 Paramecium tetr...
A0E6W5       254 -------KGFDGLFGHF-QYKSDPmr------------------eIKRQFSSKKE--RESFKPadLgnktrPNPTISCFk 305 Paramecium tetr...
XP_001566595 268 fcgyanrIGEQGCLNPFPNVWVHPDEmqlsksa------qrkqaqEEAGRPPKGA---GVWRP--N-----SFEKTSVVs 331
XP_003722339 340 fygsanrSGEPGCLNPFPNLWVHPDEtqpskial---rkqaqkekEEAARQPKRT---EVWRP--N-----SFGKTSVVs 406
Q4E651       269 msfkrtkSGQEGCIADFPNTWIDPDAlerernkgk--kknrkpkpEYVPSPPKGA--SGIWKP--N-----SFPEASVVq 337 Trypanosoma cruzi
XP_002508712 292 -----------GPMNPFPEHMADPEElqk--------------wkERRREKEGRAkiTKAWRP--Ggg-gkSGATKSVLr 343
Q57V66       273 mtfvwtrSGNEGNIDPFPNTWIDVAAleeeekkknrrrrrakakdTYVPGPPKGA--TGVWKP--N-----TFECTSVVq 343 Trypanosoma brucei
8OTZ_W       290 lnVK 293 domestic cattle
A0CLN6       300 -qLR 302 Paramecium tetraurelia
XP_004040205 326 lnIR 329
A0CX61       307 hnLK 310 Paramecium tetraurelia
A0E6W5       306 mnIR 309 Paramecium tetraurelia
XP_001566595 332 scLR 335
XP_003722339 407 scLR 410
Q4E651       338 scLR 341 Trypanosoma cruzi
XP_002508712 344 mnTR 347
Q57V66       344 scLR 347 Trypanosoma brucei
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