Conserved Protein Domain Family
CCDC66

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pfam15236: CCDC66 (494930 is an unknown moldel)
Coiled-coil domain-containing protein 66
This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.
Statistics
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PSSM-Id: 494930
Aligned: 11 rows
Threshold Bit Score: 115.698
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002085686  445 HDLKD-SEDDVQSMQSSS-----------TYLRGQNAPLDAHTLAERMDKRRKAAEYHNAIKKQLHERELIRKWEQERHR 512 
XP_056660176  471 PLSGGqLGSAEENLGKSTqdvattnvektSFLRSMTALLDPAQIEERDRRRQKQIEHQKAITAQVEEKRRKKQLEEQQRK 550 
F1PZQ5        411 TTGSQvEPSEEEHIAKPVrdmamansqktNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEQQRK 490  dog
1_pfamImport    1 TDGSQvGPSEEEHTAKPVrevamtnhqktNFLRSMTALLDPAQIEERDRRRQKQLEHQSLSIEQVYNTKGLKCLNNSLEV 80  
XP_008103460  452 TTSCHsTPTEIEVSGKTSrsnisessqkaSFLRSMTALLDPAQIEERERRRQKQLEHQKAIMAQVEEKRKQKQLEVEQRK 531 
XP_006005815  482 STLAPfSPSGTESLGRASvvtnlgqsqknSFLRTMTALLDPAEIDEREKRRQKQFEHQKAIAIQVEERRRQKQLEEERRQ 561 
EFX72153      269 PPRWVaRPTNATFVQTEPlms-----ggpSFLRGQNVVVDVAELAERERKRAKANELQRVLLQQLAEKENQKLLEKKRQQ 343 
XP_011069136  280 SQVLViNHDSASSPDSSTtgstgsdinkvSYLRGQNIPMDAEILQEREMKRQKALELQNAIKQQLEEKDRQRKEEKERRL 359 
XP_002048096  446 HDLKD-SEDDVQSVQSSS-----------TYLRGQNAPLDAHTLAERMDKRRKAAEYHNAIKKQLHERELIRKWELERHR 513 
XP_046867863  376 KD----SEDDIQSLQSSS-----------TYLRGQNAPLDAHTLQERIDKRRRAAEYHNAIKKQLHERELIRKWELERHR 440 
XP_001985289  460 HDLKD-SEDDVQSMQSSS-----------TYLRGQNAPLDAHTLAERMDKRRKASEYHNAIKKQLHERELIRKWELERQR 527 
XP_002085686  513 QEEQIEEERIRRQKQLEQERLEFERRTLLEREEAQQKKQQVMLDAIQKAEVAAKIEKQKRRMVHQPskvsqeteeddeae 592 
XP_056660176  551 QEEDEEERRLAREREEMQRRFEEDLLEQKRKEEMMALKTSELYQSMQRAQELAQRLRQEQRIRELE-------------- 616 
F1PZQ5        491 KEEQEEERRLAREREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELA-------------- 556  dog
1_pfamImport   81 LVKGEVVGRLAREREEMQKQYEEDILKQKQKEEIMTFKTSELLQTMQRAQELAQRLKQEQRIRELA-------------- 146 
XP_008103460  532 QEDQEEEQRLAKEQELMKKQFEEDLLKQKQKEEIMALKTNVLYQTMQKAQELAQRLKQEQRIKELA-------------- 597 
XP_006005815  562 QEELEEELRLEQEREKIQKQFEEDVLKQKQKEELLTRKTNELYQSMQRAQEQALRLKQEHRMRELA-------------- 627 
EFX72153      344 EEEERQELELQRHLEAERRQIEEERRRVQEKKEAEERRLEAVKEAIAGAQQNALAEKL-ARRRNL--------------- 407 
XP_011069136  360 REEMLEEERIRRERERDKARFEEEQRIIREKEEAKLRKTQAMREVLEAAERLAKEDGKNRRKRE---------------- 423 
XP_002048096  514 QEEQLEEERMRRQKQLEQERLEFERRQLQEREEAQKKKQQAMLDAIAQAEMAAKMEKQKKRKNRMP-------------- 579 
XP_046867863  441 QEEQMEEDRLRRQKQMEIERLEYERRQALEREEAQKKKQQVMLDAIAKAEVAAQKEKQKKRKNREE-------------- 506 
XP_001985289  528 QEEQLEDQRIRRENLMEQERLDYERRQLLEREEAARKKQQALLDAIAKAELAAKIEKQKKRQKHVPpieqspsqer-pel 606 
XP_002085686  593 lmrvqsvEEEEDAEE 607 
XP_056660176  617 -------QKGHDISN 624 
F1PZQ5        557 -------QKGHDTSG 564  dog
1_pfamImport  147 -------EKGHDTSR 154 
XP_008103460  598 -------EKGHDTSK 605 
XP_006005815  628 -------RKGHDISN 635 
EFX72153      408 -------QNRTAVVQ 415 
XP_011069136  424 -------EHTDEDTD 431 
XP_002048096  580 -------SKEHRQSQ 587 
XP_046867863  507 -------VKVKTTTK 514 
XP_001985289  607 lrvlsveEEEEEQQQ 621 
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