Conserved Protein Domain Family
TMEM95

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pfam15203: TMEM95 (This model is not part of the current CDD release)
TMEM95 family
TMEM95 and its homologues can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilisation.
Statistics
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PSSM-Id: 521700
Aligned: 9 rows
Threshold Bit Score: 233.143
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P0DJF3        17 CIFCRLQDHALANRLAQLNNQTKPkwKWKEW----ASPDFSAFAL-DEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQW 91  house mouse
5_pfamImport   1 CLFCRLPAHGLSGRLARLCSQIEA--QWKDCe---ASWNFSTFAL-DEVSLNKVTEKTHRVLRVMEIKRSFSSLPLYWQW 74 
2_pfamImport   1 CIFCRLPDRDLSGRLARLCSQMEA--QWKEW----ASPDFSAFAL-DEVTMNKVTEKTHRVLRVIEIKRSLSSLPPYWQW 73 
3_pfamImport   1 CIFCRLPDHGLSGRLHQLCSQMEA--QWKDCe---ASWNFPAFAL-DDTSMNKVTEKTHRVLRVVEIKGSLSPLPAYWRW 74 
XP_010594872  17 CVFCRLPAHDLLSRLDRLCSQMEV--QWEACe---ASRDFSAFAL-DEVSMNKITEKTHRVLRVMEIKGSFSSLPLYWEW 90 
XP_007483257  17 CIFCRLPSRDLSGRVAHLCDQISS--EWENCk---TSWNFSAFAL-DDVSMNRITEKTHRVLSIFEIKGSVFSLSSYWHW 90 
XP_014345104  25 CVFCSLKYKNVENRFHQLCSGYMKtyNKTRCskymENTDFDDFAF-HENKVIQITEKTHRVFRVLEINRSLADLPQYWDW 103
NP_001128271  17 CVFCRLPAHALPSRLAQLNKQTEP--QEKEC----ASSSSFLSIStDEVSMNQITEKTHRVLRVIEIKRSISLLPLYWQW 90  Norway rat
NP_937797     17 CVFCRLPAHDLSGRLARLCSQMEA--RQKECg---ASPDFSAFAL-DEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSW 90  human
P0DJF3        92 LQKTRIPQYTREA-------L-CAPVC--------RGSTILYNCSTCEGKEESCWPQKHCYPDSHDLWDARILLLCIFGI 155 house mouse
5_pfamImport  75 LQETKFPEYNREA-------L-CSPAC--------WGSTILYNCSTCEGFEVLCWPQKRCFPGSHDLREARILLLCVFGT 138
2_pfamImport  74 LQKTLIPQYTREA-------L-CAPACllrplspaGGSTILYNCSTCRSAEVSCWPRKRCSPGSHDLWEARILLLCVSGA 145
3_pfamImport  75 LQKTKLPEYNREA-------L-CAPACplvplspaGGSTTLYNCSTCEGFEVHCWPRKRCFPGSHDLWEARILLLSVSGT 146
XP_010594872  91 LHNTKLPEYTREA-------L-CAPAC--------RGSTTLYNCSTCEGVDVHCWPRKLCFPGSHDLWEARILLFSVFVA 154
XP_007483257  91 LQETKLPESVRQA-------L-CPPAC--------RGITTLYNCSTCKAVEVQCWALKRCFPGRQDLREARILLLSLSAA 154
XP_014345104 104 LFEKKLVEYTHQV-------L-CPPTC--------RGFVRTVNCTTCQREKVDCWDFKRCYPEKLSLQESVYLLIIISVA 167
NP_001128271  91 LRKTKIPQYTREA-------L-CAPVCplfllspaGGSTILYNCSTCEGKEESCWPQKRCFPGSHDLWDARILLLCIFGI 162 Norway rat
NP_937797     91 LRKTKLPEYTREAlcppacpLpLLSPA--------GGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGA 162 human
P0DJF3       156 VLLSGVVSLQVEY 168 house mouse
5_pfamImport 139 ILLLGVLSLVVKT 151
2_pfamImport 146 ALLLGVLSLLVES 158
3_pfamImport 147 VLLLGFLSLSVEY 159
XP_010594872 155 VLLLSVLSLVVES 167
XP_007483257 155 LLILGFISCIIES 167
XP_014345104 168 CFAIGTFSFFSEY 180
NP_001128271 163 VLLLGALSLQVEY 175 Norway rat
NP_937797    163 FLLLGVLSLLVES 175 human
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