Conserved Protein Domain Family
NPBW
?
pfam15180: NPBW (This model is not part of the current CDD release)
Neuropeptides B and W
The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.
Links
?
Statistics
?
PSSM-Id: 521693
Aligned: 18 rows
Threshold Bit Score: 114.403
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EGW04445      18 LLPLLLV---LLLPLPAGAWYKHVASPRYHTVGRASGLLMGLRRSPYLWRRAL-GGAVGPLSRdt----------lVPGP 83 
Q8NG41         6 TLAAAALalcLLLAPPGLAWYKPAAGHSSYSVGRAAGLLSGLRRSPYARRSQP-YRGAEPPGGag----------aSPEL 74  human
XP_040048065   9 PVLVVSL---LAAGGPSEAWYKQAAGPSYYSVGRASGLLSGIRRSPYVRRAEPePADSDEPADen---------afAQLT 76 
XP_003450170   8 ALPIVVIs-vLVACSPTEAWYKQVAGPTYYSVGRASGLLSGIRRSAYVRREEPhHADTDESATnn---------vfSEIP 77 
XP_005989170  11 ALVCVAIs-lLISCQPSEAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSES-ETGTETGDTtgn--------nlVSEP 80 
3_pfamImport   1 ALVVAAIs-mLISCHPTAAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSEP-EAMAESGEStgnf-----mtemGSQA 73 
NP_001120841   8 VLVFVAVs-iLISSHPTDAWYKQSTGPSYYSVGRASGLLSGIRRSPYVRRSEG-ESALDSGETpgvsnsvlaelssSNSG 85 
Q4S001         8 TVVCVAVs-lLISGDLVEAWYKQSTGPSYYSVGRASGLLSGIRRSPYARRSESeETMLDSEDApgn--------svTPEN 78  spotted green p...
XP_005805134   8 AVVCVGVs-lLISCQSVEAWYKQVTGPSYYSVGRASGLLSGIRRSPTVRRAESeETVMDSGEAagn-------nliQETN 79 
XP_004066211   8 AVVCVGVs-lLVSCHSAEAWYKQSTGPIFYPVGRASGLLSGIRRSPYVRRAESeEVLADSKEAaen-------svtHDAS 79 

EGW04445      84 VTGStlPLLPSPVQELWETRRGswraglpvyePRSPRDLERARQ--PEQSLSLRSWISAE 141
Q8NG41        75 QLHPrlRSLAVCVQDVAPNLQR----------CERLPDGRGTYQckANVFLSLRAADCLA 124 human
XP_040048065  77 AQNFilKTMPVCIKDISPDLQS----------CE-LQEITGSFKckADIFLTLDSADCGG 125
XP_003450170  78 ASSSilKTMPVCIKDITPNLQS----------CERIQDIKASFRckADVFLSLDSSDCEA 127
XP_005989170  81 RQTAilKSMAICVKDISPNLQS----------CELLQDGMNTFQckADVYLSLDSQDCMN 130
3_pfamImport  74 RQTAflKNMAVCVKDISPNLQS----------CELVQDGMSTFQckADVYLSLDSQDCVN 123
NP_001120841  86 RQTPvlKNMAICVKDISPNLQS----------CELLQDGSSSFRckADVFLSLDSLDCFT 135
Q4S001        79 RQISllKSMAICVKDISPNLKS----------CELLRDGTGTFQckADVFLTLDSLDCLS 128 spotted green pufferfish
XP_005805134  80 KQISvlKNMAICLKDISPNLKS----------CELLQDGTGTFQckADVFLTLDSLDCLS 129
XP_004066211  80 RQISalKDMAICVKDVSPNLKT----------CELLRDGTGTFQckADVFLTLDSLDCLS 129
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap