Conserved Protein Domain Family
LRR19-TM
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pfam15176: LRR19-TM (This model is not part of the current CDD release)
Leucine-rich repeat family 19 TM domain
LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 521692
Aligned: 6 rows
Threshold Bit Score: 200.84
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003407373 267 NLTRNPEHERFGKSWAFLVGVAVSVLMTSLLIFIAIKCPLWYSFVLSYNHHRLEEHEAETYEDGCTGNPSSLSPAPNTNS 346
XP_007498146 257 NKTKNAESEPSGKSWALLVGVVVVVTVTSMLIFIAIRCPTWYNFFFSYNHHRLDEQEADTYEGDFTVYPNSLPQTPDTNP 336
Q8BZT5       250 NLTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNS 329 house mouse
XP_003782893 256 NLTRDSEHGPLGKSWAFLVGVVVTVLMTSFLIFIAIKCPIWYNILLSYNHHRLEEHEVETYNESFNGNPSSFSQISATNP 335
XP_005334245 256 NFTRNSEHEPLGKSWVFLVGVVVTALMTSLLILTAIKCPIWYNFLLSYNHRRLEEHEAETYEDGFPGNSNSLPHIGDINS 335
XP_036753992 256 nltRNSEHEPLGKSWAFLVGVVVTLLMTSLLIFIAVKCPIWYNFLLSYNHHRLEEHEAETYEDGFTGNPSSLSQIPDTNS 335 Chinese pangolin

XP_003407373 347 EETTVIFGQLPSFAVDDDGFIEDKYIDTHELHEEN 381
XP_007498146 337 DDSIVIFDQLSSFMVDEDGFIEDKYIDTQEMREEN 371
Q8BZT5       330 EDTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364 house mouse
XP_003782893 336 EDTTVIFERLHSFVVDDDGFIEDKYIDTHELCEEN 370
XP_005334245 336 EDTTVIFEQLHSFVAEDDGFIEDKYIDTHELCEEN 370
XP_036753992 336 EEATVIFEQLHSFVVDDDGFIEDKYIDTHELREEN 370 Chinese pangolin
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