Conserved Protein Domain Family
Spexin

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pfam15171: Spexin (This model is not part of the current CDD release)
Neuropeptide secretory protein family, NPQ, spexin
Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance.
Statistics
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PSSM-Id: 521688
Aligned: 5 rows
Threshold Bit Score: 107.696
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003220804  27 APQAHFQRRNWTPQAMLYLKGAQGRRFISEESQRKDLYDRLQLETRSQNMSPLTLSEAAALFLSALRKaAQEegDEEEGE 106
2_pfamImport   1 APQRLLERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLSDRLPPERRSPNPQLLPLPEAAALLLALLSK-PQEgtNREEKF 79 
D3Z752        27 APQRLSEKRNWTPQAMLYLKGAQGRRFLSDQSRRKELADRPPPERRNPDLELLTLPEAAALFLASLEK-SQK--DEGGNF 103 house mouse
Q0VC44        27 APQRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLSDRPPLERRSPNSQQLTLPEAAAVLLAFLQK-PQE--AGDENL 103 domestic cattle
Q9BT56        27 APQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQK-SPE--DEEKNF 103 human
XP_003220804 107 EKPgYVSDGLLNW 119
2_pfamImport  80 DRS-FLQDRMLSW 91 
D3Z752       104 DKSeLLEDRLFNW 116 house mouse
Q0VC44       104 DQTrFLEDSLLNW 116 domestic cattle
Q9BT56       104 DQTrFLEDSLLNW 116 human
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