Conserved Protein Domain Family
SCRE
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pfam15162: SCRE 
Protein SPO16 homolog
This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.
Links
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Statistics
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PSSM-Id: 494877
Aligned: 10 rows
Threshold Bit Score: 242.73
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014347285   9 AKWTTTVIISSTLRSHEVATSLISQQHRVRFSDTVEEGSIIFSLSGVAFIIVDVQKLFGNVEEaVLLAKLEKFMCIHRNS 88 
Q3KQP7        12 VQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEE-IFVTKIEKFINIHQNS 90  house mouse
XP_003990350  10 IKWTTTIIISSSLKSCEVATALD-RSHKIRYSDSVENGSIIFSLSGVAFLLMDAKDCFTSAEE-IFLAKIEKFTNIHQNS 87 
4_pfamImport   1 NKWKELXIASASLQSHETALALSAQQHRVRYSDSVEEGTYIFPLSGIAFMIVDTQECADSPGVsRLFEKIGKFIQVHRNS 80 
3_pfamImport   1 SSWKTTVIVSTSLQNHEALWMILSQQHRLRFSDSVEHGALVFPLSG-NFILQHTLPPSKSESS-KFFNRIEKF------- 71 
XP_003444305   9 PQWKTTIIVSTSLQSHEIIRMLNAQQHRIRFSDSVHPGAFIFPLSGTAFLMVDPQDLPEPSEEsGVFERIKKFVQVHRNC 88 
XP_005807175   9 AQWRTTIIISSSLQNHDTCRTLSAQQHRIRFSDSVEAGAFIFPLSGTAFLLVDPQDLPEPLEEsGLTERIGKFVQVHRNC 88 
2_pfamImport   1 -------------------MSLQNQKHRIRYSDSVEDGCIIFSLSGVAFLLADAQGLFVTDRE-VFFERIKKFMSIHRNG 60 
NP_001264582  10 SKWSTTVIMSTGLQNHEISTILQRQQHRVRYSESVEIGSVIFSLSGVAFLLADIQDLLARGEE-QFLERIQKFINIHRNG 88 
XP_001376990  10 SKWTTTVIMSSSLQSHEVAAILKNENHRVRYSNSVEPGSIIFSLSGVAFLLIDAQECFRTTEE-TLLARIEKFIRIHRNS 88  gray short-tail...

XP_014347285  89 FLLLLAALHETREWETMIRIQQRFLGSNLRIIPVHNTNDIVKSILTIAKATCKPAVDNIWCRMVMATAQITDRSLVWEML 168
Q3KQP7        91 FLVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTL 170 house mouse
XP_003990350  88 FLVLSAAFHGPEEWKLMFRIQQRFLGSNLRILPVHNTVDVINLMCTIAKMASKPYTDNICYRMVTTEAYIIEQSPVWKTL 167
4_pfamImport  81 FLLFSSSLHAQREQEILFRIQQSFLGSKLRIIPVHNVAEMVKSMLTIAKATSKPHVDSVRDRMALARAQIIERSPVWDVL 160
3_pfamImport  72 -----SPVYGAREWEIVI-LQQLFFGSNLKVLPLHSNVDIVKALLTIAKATSKPLVDSIRERMALARAQIIERSPVWEVL 145
XP_003444305  89 FLLLHSPFKGKKELETLTVIQNRFFGSNLRILPVQNTDEIVKGMLTIAKATSKPHVDSIRDRISLARAHIIESSPVWEML 168
XP_005807175  89 FLLLYSPFNGEKELQVLTVIQHRFIGSNLKILPVRNGAQIAKGMLTIAKATSKPHADKIRERMSLARAHIIETSPVWEML 168
2_pfamImport  61 FLLLSAALHGPKEWDVMFKVQQRFLGSNLRIIPVHNTAEAIKLMLTIAKTTSKPHLDNIRYRMLMAKSQIVEQSPVWKML 140
NP_001264582  89 FLVLSAALHGPQEWNVMFRIQRRILGSNLRIIPVHNTAETVKLMLTIAKMNSKPRADDVSQKMAMTKTHIIENSPVWKML 168
XP_001376990  89 FLALSSALHGPGEWRLMSRIQQRFLGDNLRIVPVHNPGNAVKLMTTIAKSTCKPYSDNIHYRMILAKAQIIEQSPVWRTL 168 gray short-tail...

XP_014347285 169 HKL 171
Q3KQP7       171 QKI 173 house mouse
XP_003990350 168 QKL 170
4_pfamImport 161 SRL 163
3_pfamImport 146 GHM 148
XP_003444305 169 RDM 171
XP_005807175 169 RDI 171
2_pfamImport 141 HQR 143
NP_001264582 169 QEY 171
XP_001376990 169 QKL 171 gray short-tailed opossum
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