pfam15157: IQCJ-SCHIP1 (This model is not part of the current CDD release)
Fusion protein IQCJ-SCHIP1 with IQ-like motif
This entry includes eukaryotic fusion proteins. It bridges two adjacent genes that encode distinct proteins, IQCJ, a novel IQ motif containing protein and SCHIP1, a schwannomin interacting protein. It contains a unique calmodulin-binding IQ motif at the N-terminus not shared with its shorter isoform SCHIP1, suggesting a distinctive function for this protein. It is localised to cytoplasm and actin-rich regions, and in differentiated PC12 cells is seen in neurite extensions. It may play a role in action potential conduction in myelinated cells through the organisation of molecular complexes at nodes of Ranvier and axon initial segments. This model covers an N-terminal segment that is mostly disordered and includes the IQ motif.
Jiyao W et al.(2023). "The conserved domain database in 2023.",