Conserved Protein Domain Family
TASL

?
pfam15133: TASL (This model is not part of the current CDD release)
TLR adaptor interacting with SLC15A4 on the lysosome
In humans, TASL (TLR adaptor interacting with SLC15A4 on the lysosome) is encoded by CXorf21 that is associated with systemic lupus erythematosus. It is an immune adaptor that is required for recruitment and activation of IRF5 by TLR7, TLR8 and TLR9, in mechanistic analogy to IRF3 and its three adaptors STING, MAVS and TRIF. TASL interacts with the endolysosomal transporter SLC15A4 forming the SLC15A4-TASL complex, which is required for endolysosomal TLR signalling. TASL contains a pLxIS motif that is important for its function.
Statistics
?
PSSM-Id: 521669
Aligned: 14 rows
Threshold Bit Score: 311.285
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006008195   1 MLSETFLCAIPYLQEDENGA--------------TPHCESI---QGKRMHEMTSLCDNTDSPNGTTQSRSLFKRYRSLGR 63 
Q9D3J9         1 MLSEGYLSGLTYWNDIHWNC--------------ASYNEPV---AGDQGKETSSVAALSYSSVDETQVQSLYVSCKSSGK 63  house mouse
XP_003218959   1 MLSEGYLYGIPYL---------------------DLLNHELchkQEESARELKSLNGIIYESAKEANDKT-FWSCRSVGK 58 
XP_003640560   1 MLSEGYLYRIAYLCEDS-----------------ELCTNQA---VEEVVYEMRSIN---CSSRDEAQVKSLLQRCRSAGK 57 
XP_030138289   1 MLSEGYLHRITYLWEDLQ----------------PALYESL---PDEGVYEMRPIN---YSSTVEAQGKSLLQRCRSAGK 58 
XP_006002453   1 MLGEGFLLGIGY--EQDKHHrqlapydcqnsrkgCARQDSW---ENLAEDFILVDDAMSKVQVMEGKSQS---------- 65 
Q8BHV4         1 MLGEAFLTKFLY--KEQRHAklykp-----lrckKTSNDKK---ENWENKLLDTPDNSLSPLKTGSQEKV---------- 60  house mouse
XP_030128299   1 MLAEGILTRLIY--KESCHQdkpc-------kspASQKAKE---GIWRQKLVDNPEIKGFADGCEKREEL---------- 58 
3_pfamImport   1 MLAEGILTSLVY--KESCHQdkph-------kshAAKQDEE---GNWREKLVDNPKITGLADGCETQDRI---------- 58 
XP_005475563   1 MLCEGRLLIMTYCEFED----------------------------------LDSLPSKPAFQNAYGSQKTAAALIPGSTR 46 
XP_006008195  64 LVTSLRPEEGREYRKEVFTQPGRNKvp------------eRQLSPVVDIPRGSSVSK-ETYLVPS-SCKSICKNYNDLHI 129
Q9D3J9        64 FISSVHARASQHSRSQSRTVLQANSnpv----------feSPTLAAVGICRD--VIR-ETYLVPP-SCKSICKNYNDLHI 129 house mouse
XP_003218959  59 LIYSVCSKENRNSRKQKTTLAQTNQnpl----------feHRSSAALDISMGYGVNG-DTYLVPP-SCKSICKNYNDLHI 126
XP_003640560  58 CISAVHSRGSKHSRRQKDNLQQSVQnpl----------peGQTSPTMDVCEG--LVRkDTYLVPS-SCKSICKNYNDLHI 124
XP_030138289  59 RISSVCSRGSKHSRRQKDNLPQPVQhpm----------ptGQPPPATHVCEE--PTKkVTYLVPP-SCKSICKNYNDLHI 125
XP_006002453  66 -APDIKESKLENVLQYQLTQEELKKdcpra------siltKQTSDAVPVPRSYQHIEpHLDLYTSwSCKNIYWNYPDLHI 138
Q8BHV4        61 ---IEGSVTEQDNDSSQIKSMDELPvakck-----ctplpGNVSVALPIPKRGQ-EEtQLDLYRSwSCTSICQNYPDLQI 131 house mouse
XP_030128299  59 ---SARSSEVEAGSCPRWGSVEKEPardqe------mlvkGTASPALHIPRRGGSLD-QVDLYRSwPCNSIYQDYPDLQI 128
3_pfamImport  59 ----SAKSDMEHKRDPQQRPILGFPardqk------tlvkGTVSPALHIPRREQYNE-QMDLYRSwSCNSIYQNYPDLHI 127
XP_005475563  47 HAPLVHHNSPEQMATDNRRASAELYisplqsldlqrahlgRQISREIEIPAQAHSGGdTPFLVPS-FCQSICKNYSDLHI 125
XP_006008195 130 AGDQVMPIGSKSTDFTYDSSFDFcdGPFLQSSEIPPPL-ESLKSSK--EFLSRPTGP------DSSLWRGGSIRYKSII- 199
Q9D3J9       130 AGGQVMAINSVMANFPSESSFED--GPLLKSSEISLSMeDSTSTQLt-ELPLKPIQR------YSSYWRITSIKEKSSL- 199 house mouse
XP_003218959 127 AGDQVLPMSSVKRDFTYNSGI----GPFLESSEIPPPI-ESISLPPa-DNPPKPVQG------YSSCWRVASIM------ 188
XP_003640560 125 AGDCVVPISSVATDFTCDSGI----GPFLESSEIPPPM-ESVRVPPs-ETGRKQAQG------FSSCWRVASLV------ 186
XP_030138289 126 AGDYVVPISSVTTDFACDSGI----GPFLESSEIPPAM-ESVKAPPasDTIRRPGQG------HSSCWRLASLG------ 188
XP_006002453 139 GGDHVGDIDTSDVLYVTERELQNcdGPILHSVDMDPA--------------SSPPRSclenhqAAVVANAEEVPEKGFP- 203
Q8BHV4       132 GGDHIR-NMYDSGCFVEHTYDDVcnGPLLLSVDIPLG-----HSPKm-EPLEKTSTS--------KLFNGDEIREKSML- 195 house mouse
XP_030128299 129 GGDRVGGHTCDSGCVLDHVCDELpdGPVLLSIDIPLG-----QSPQ----CEHPKKP------SGMSLPGDEAGERSLV- 192
3_pfamImport 128 GGNRVGDHTCDSGCVLDHVCDELpdGPVILSIDIPLG-----ESPL----CEHLDKS------GSQSLPGDDAGERSIM- 191
XP_005475563 126 AGDQVLPLSANNCELRVCADVPDv-GPFIQSCDVPPAVeDSLQGHEarDGRLFPLRG------GSNRWRLGSGRDRSFFl 198
XP_006008195 200 -QGLQPLSNSMLNDYLEQKVLELYKQYLMDSMVNSASPTK---------IMASELIMNNLDQITLQISKEQNMETTKAKD 269
Q9D3J9       200 -QMQKPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQ---------ILASEFIMTNVDQISLQVSKEKNLDTSKVKD 269 house mouse
XP_003218959 189 -QHQQPLSNSILNNYLEEKVVELYKQYIMDGMGSSASPTH---------ILASEFIMTNVDQISMKLTQEKKMNSTIAKD 258
XP_003640560 187 -PHQQPLSDSALNDYLEQKLMELYKQYIMDSTVNRASPTQ---------ILASELIMTNVDQISTQISRERKMETTKAKD 256
XP_030138289 189 -PHQQPLSDSALNDYLEQKLLELYKQYIMDSTANRASPTQ---------ILASELIMTNVDQISMQISRERNMETVKAKD 258
XP_006002453 204 -LPKQPLSNSILNNYMEEKIIELYKQYLEDSLSRNASPTQ---------ILTSSFVLHNVHQLSLHISQEQNMETTRAKE 273
Q8BHV4       196 -LHKQPLSNSMLNNYIERKVDELYKQFLEENLTRCLSITN---------LMTSSILMNNVNQISLQISQEQNIEASKARE 265 house mouse
XP_030128299 193 -LSEEPLSNSTLNKYMEAKVAELYKQFFDESLARCGSITN---------LLTCSWIRNSLDQISVQISQEQNIETSKARG 262
3_pfamImport 192 -LCEEPLSNSMLNNYMETKVAEFYKLFFEENLTRCGSVRN---------LLTCSLIRNNLNQISFQISQEQNIEASKARE 261
XP_005475563 199 qGHEGPFSNSLLNHYLEQKLLDLYQQYMMENMAREGAPGSdsdtsaicpLLGSELVLTSLDQITLQLSREGNMEAGLAKD 278
XP_006008195 270 MVISCL----LRVAsgkqSTELSTPNLQISSD 297
Q9D3J9       270 IVISHL----LQLV----SSEISTPSLHISQY 293 house mouse
XP_003218959 259 MVINCL----LQLAsgkvSTEMSTPSLHISQF 286
XP_003640560 257 IVISRF----LQIAseqiFSEISTPSLHISQY 284
XP_030138289 259 IVISRF----LQIAsgkvSSEMSTPTLHISQY 286
XP_006002453 274 MVLNCL----FSVVsg-nSSEFSTPNLQISHI 300
Q8BHV4       266 ALLHSLalcnLRNVshrnSTELSTPNLQISNQ 297 house mouse
XP_030128299 263 ALLHSLalfsSRNApnrnSSEFSTPNLQISNI 294
3_pfamImport 262 VLLQSIalfsLHNTtnrsSSEFSTPNLQISNP 293
XP_005475563 279 MVLSCF----LRVAgdmqSSEISTPFLQISNE 306
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap